HMGB6_ARATH
ID HMGB6_ARATH Reviewed; 456 AA.
AC Q9SUP7;
DT 02-NOV-2010, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2000, sequence version 1.
DT 03-AUG-2022, entry version 135.
DE RecName: Full=High mobility group B protein 6;
DE AltName: Full=Nucleosome/chromatin assembly factor group D 06;
DE Short=Nucleosome/chromatin assembly factor group D 6;
DE AltName: Full=WRKY transcription factor 53;
DE Short=AtWRKY53;
DE Short=WRKY DNA-binding protein 53;
GN Name=HMGB6; Synonyms=NFD6, WRKY53; OrderedLocusNames=At4g23800;
GN ORFNames=F9D16.270, T32A16.2;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10617198; DOI=10.1038/47134;
RA Mayer K.F.X., Schueller C., Wambutt R., Murphy G., Volckaert G., Pohl T.,
RA Duesterhoeft A., Stiekema W., Entian K.-D., Terryn N., Harris B.,
RA Ansorge W., Brandt P., Grivell L.A., Rieger M., Weichselgartner M.,
RA de Simone V., Obermaier B., Mache R., Mueller M., Kreis M., Delseny M.,
RA Puigdomenech P., Watson M., Schmidtheini T., Reichert B., Portetelle D.,
RA Perez-Alonso M., Boutry M., Bancroft I., Vos P., Hoheisel J.,
RA Zimmermann W., Wedler H., Ridley P., Langham S.-A., McCullagh B.,
RA Bilham L., Robben J., van der Schueren J., Grymonprez B., Chuang Y.-J.,
RA Vandenbussche F., Braeken M., Weltjens I., Voet M., Bastiaens I., Aert R.,
RA Defoor E., Weitzenegger T., Bothe G., Ramsperger U., Hilbert H., Braun M.,
RA Holzer E., Brandt A., Peters S., van Staveren M., Dirkse W., Mooijman P.,
RA Klein Lankhorst R., Rose M., Hauf J., Koetter P., Berneiser S., Hempel S.,
RA Feldpausch M., Lamberth S., Van den Daele H., De Keyser A., Buysshaert C.,
RA Gielen J., Villarroel R., De Clercq R., van Montagu M., Rogers J.,
RA Cronin A., Quail M.A., Bray-Allen S., Clark L., Doggett J., Hall S.,
RA Kay M., Lennard N., McLay K., Mayes R., Pettett A., Rajandream M.A.,
RA Lyne M., Benes V., Rechmann S., Borkova D., Bloecker H., Scharfe M.,
RA Grimm M., Loehnert T.-H., Dose S., de Haan M., Maarse A.C., Schaefer M.,
RA Mueller-Auer S., Gabel C., Fuchs M., Fartmann B., Granderath K., Dauner D.,
RA Herzl A., Neumann S., Argiriou A., Vitale D., Liguori R., Piravandi E.,
RA Massenet O., Quigley F., Clabauld G., Muendlein A., Felber R., Schnabl S.,
RA Hiller R., Schmidt W., Lecharny A., Aubourg S., Chefdor F., Cooke R.,
RA Berger C., Monfort A., Casacuberta E., Gibbons T., Weber N., Vandenbol M.,
RA Bargues M., Terol J., Torres A., Perez-Perez A., Purnelle B., Bent E.,
RA Johnson S., Tacon D., Jesse T., Heijnen L., Schwarz S., Scholler P.,
RA Heber S., Francs P., Bielke C., Frishman D., Haase D., Lemcke K.,
RA Mewes H.-W., Stocker S., Zaccaria P., Bevan M., Wilson R.K.,
RA de la Bastide M., Habermann K., Parnell L., Dedhia N., Gnoj L., Schutz K.,
RA Huang E., Spiegel L., Sekhon M., Murray J., Sheet P., Cordes M.,
RA Abu-Threideh J., Stoneking T., Kalicki J., Graves T., Harmon G.,
RA Edwards J., Latreille P., Courtney L., Cloud J., Abbott A., Scott K.,
RA Johnson D., Minx P., Bentley D., Fulton B., Miller N., Greco T., Kemp K.,
RA Kramer J., Fulton L., Mardis E., Dante M., Pepin K., Hillier L.W.,
RA Nelson J., Spieth J., Ryan E., Andrews S., Geisel C., Layman D., Du H.,
RA Ali J., Berghoff A., Jones K., Drone K., Cotton M., Joshu C., Antonoiu B.,
RA Zidanic M., Strong C., Sun H., Lamar B., Yordan C., Ma P., Zhong J.,
RA Preston R., Vil D., Shekher M., Matero A., Shah R., Swaby I.K.,
RA O'Shaughnessy A., Rodriguez M., Hoffman J., Till S., Granat S., Shohdy N.,
RA Hasegawa A., Hameed A., Lodhi M., Johnson A., Chen E., Marra M.A.,
RA Martienssen R., McCombie W.R.;
RT "Sequence and analysis of chromosome 4 of the plant Arabidopsis thaliana.";
RL Nature 402:769-777(1999).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=14593172; DOI=10.1126/science.1088305;
RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA Ecker J.R.;
RT "Empirical analysis of transcriptional activity in the Arabidopsis
RT genome.";
RL Science 302:842-846(2003).
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00267}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=1;
CC Comment=A number of isoforms are produced. According to EST
CC sequences.;
CC Name=1;
CC IsoId=Q9SUP7-1; Sequence=Displayed;
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DR EMBL; AL035394; CAA23046.1; -; Genomic_DNA.
DR EMBL; AL161560; CAB81298.1; -; Genomic_DNA.
DR EMBL; CP002687; AEE84807.1; -; Genomic_DNA.
DR EMBL; AY074353; AAL67049.1; -; mRNA.
DR EMBL; AY096398; AAM20038.1; -; mRNA.
DR EMBL; AY125491; AAM83212.1; -; mRNA.
DR PIR; T05612; T05612.
DR RefSeq; NP_194111.1; NM_118511.3. [Q9SUP7-1]
DR AlphaFoldDB; Q9SUP7; -.
DR SMR; Q9SUP7; -.
DR STRING; 3702.AT4G23800.1; -.
DR iPTMnet; Q9SUP7; -.
DR PaxDb; Q9SUP7; -.
DR PRIDE; Q9SUP7; -.
DR ProteomicsDB; 228805; -. [Q9SUP7-1]
DR EnsemblPlants; AT4G23800.1; AT4G23800.1; AT4G23800. [Q9SUP7-1]
DR GeneID; 828480; -.
DR Gramene; AT4G23800.1; AT4G23800.1; AT4G23800. [Q9SUP7-1]
DR KEGG; ath:AT4G23800; -.
DR Araport; AT4G23800; -.
DR TAIR; locus:2128504; AT4G23800.
DR eggNOG; KOG0381; Eukaryota.
DR InParanoid; Q9SUP7; -.
DR OMA; YADEHEA; -.
DR PhylomeDB; Q9SUP7; -.
DR PRO; PR:Q9SUP7; -.
DR Proteomes; UP000006548; Chromosome 4.
DR ExpressionAtlas; Q9SUP7; baseline and differential.
DR Genevisible; Q9SUP7; AT.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IDA:TAIR.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; ISS:TAIR.
DR Gene3D; 1.10.30.10; -; 3.
DR InterPro; IPR009071; HMG_box_dom.
DR InterPro; IPR036910; HMG_box_dom_sf.
DR InterPro; IPR044601; HMGB6/HMGB13.
DR PANTHER; PTHR46912; PTHR46912; 1.
DR Pfam; PF00505; HMG_box; 3.
DR SMART; SM00398; HMG; 3.
DR SUPFAM; SSF47095; SSF47095; 3.
DR PROSITE; PS50118; HMG_BOX_2; 3.
PE 2: Evidence at transcript level;
KW Alternative splicing; DNA-binding; Nucleus; Reference proteome; Repeat.
FT CHAIN 1..456
FT /note="High mobility group B protein 6"
FT /id="PRO_0000399932"
FT DNA_BIND 138..206
FT /note="HMG box 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00267"
FT DNA_BIND 255..321
FT /note="HMG box 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00267"
FT DNA_BIND 379..447
FT /note="HMG box 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00267"
FT REGION 1..42
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 117..142
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 238..258
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 349..389
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 124..139
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 238..256
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 349..377
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 456 AA; 53231 MW; 3F36C7373111D4F5 CRC64;
MATNADPAPT KKPRNSRKAL KQKNELVETP PSPVSVKGKS AKSFEQDLME MQTMLEKMKI
EKDKTEELLK EKDEILRKKE EELETRDAEQ EKLKVELKKL QKMKEFKPNM TFACGQSSLT
QAEQEKANKK KKKDCPETKR PSSSYVLWCK DQWTEVKKEN PEADFKETSN ILGAKWKSLS
AEDKKPYEER YQVEKEAYLQ VIAKEKREKE AMKLLEDDQK QRTAMELLDQ YLNFVQEAEQ
DNKKKNKKEK DPLKPKHPVS AFLVYANERR AALREENKSV VEVAKITGEE WKNLSDKKKA
PYEKVAKKNK ETYLQAMEEY KRTKEEEALS QKKEEEELLK LHKQEALQML KKKEKTDNLI
KKEKATKKKK NENVDPNKPK KPASSYFLFS KDERKKLTEE RPGTNNATVT ALISLKWKEL
SEEEKQVYNG KAAKLMEAYK KEVEAYNKKS AATTSS