ID   HMGC_TETTH              Reviewed;         100 AA.
AC   P11873; P40627;
DT   01-OCT-1989, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1989, sequence version 1.
DT   25-MAY-2022, entry version 96.
DE   RecName: Full=High mobility group protein C;
DE   AltName: Full=Non-histone chromosomal protein LG-1;
OS   Tetrahymena thermophila.
OC   Eukaryota; Sar; Alveolata; Ciliophora; Intramacronucleata;
OC   Oligohymenophorea; Hymenostomatida; Tetrahymenina; Tetrahymenidae;
OC   Tetrahymena.
OX   NCBI_TaxID=5911;
RN   [1]
RP   PROTEIN SEQUENCE.
RX   PubMed=3671074; DOI=10.1093/nar/15.19.8112;
RA   Roth S.Y., Schulman I.G., Cook R.G., Allis C.D.;
RT   "The complete amino acid sequence of an HMG-like protein isolated from the
RT   macronucleus of Tetrahymena.";
RL   Nucleic Acids Res. 15:8112-8112(1987).
RN   [2]
RP   PROTEIN SEQUENCE OF 1-47.
RX   PubMed=3584238; DOI=10.1083/jcb.104.6.1485;
RA   Schulman I.G., Cook R.G., Richman R., Allis C.D.;
RT   "Tetrahymena contain two distinct and unusual high mobility group (HMG)-
RT   like proteins.";
RL   J. Cell Biol. 104:1485-1494(1987).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 9-100.
RX   PubMed=1986218; DOI=10.1128/mcb.11.1.166-174.1991;
RA   Schulman I.G., Wang T., Wu M., Bowen J., Cook R.G., Gorovsky M.A.,
RA   Allis C.D.;
RT   "Macronuclei and micronuclei in Tetrahymena thermophila contain high-
RT   mobility-group-like chromosomal proteins containing a highly conserved
RT   eleven-amino-acid putative DNA-binding sequence.";
RL   Mol. Cell. Biol. 11:166-174(1991).
CC   -!- SUBCELLULAR LOCATION: Nucleus. Chromosome. Note=Macronuclei.
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DR   EMBL; M63424; AAA30120.1; -; Genomic_DNA.
DR   PIR; A26989; A26989.
DR   AlphaFoldDB; P11873; -.
DR   SMR; P11873; -.
DR   GO; GO:0005694; C:chromosome; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   Gene3D; 1.10.30.10; -; 1.
DR   InterPro; IPR009071; HMG_box_dom.
DR   InterPro; IPR036910; HMG_box_dom_sf.
DR   Pfam; PF00505; HMG_box; 1.
DR   SMART; SM00398; HMG; 1.
DR   SUPFAM; SSF47095; SSF47095; 1.
DR   PROSITE; PS50118; HMG_BOX_2; 1.
PE   1: Evidence at protein level;
KW   Chromosome; Direct protein sequencing; DNA-binding; Nucleus.
FT   CHAIN           1..100
FT                   /note="High mobility group protein C"
FT                   /id="PRO_0000048562"
FT   DNA_BIND        12..80
FT                   /note="HMG box"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00267"
FT   REGION          81..100
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CONFLICT        75..76
FT                   /note="DM -> AL (in Ref. 3; AAA30120)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   100 AA;  11679 MW;  D14F21CFDB583176 CRC64;
     AKSKDDSKPA PPKRPLSAFF LFKQHNYEQV KKENPNAKIT ELTSMIAEKW KAVGEKEKKK
     YETLQSEAKA KYEKDMQAYE KKYGKPEKQK KIKKNKKGSK