ID   HMGH_STRPU              Reviewed;         200 AA.
AC   P40644;
DT   01-FEB-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1995, sequence version 1.
DT   25-MAY-2022, entry version 93.
DE   RecName: Full=High mobility group protein 1 homolog;
GN   Name=HMG1;
OS   Strongylocentrotus purpuratus (Purple sea urchin).
OC   Eukaryota; Metazoa; Echinodermata; Eleutherozoa; Echinozoa; Echinoidea;
OC   Euechinoidea; Echinacea; Camarodonta; Echinidea; Strongylocentrotidae;
OC   Strongylocentrotus.
OX   NCBI_TaxID=7668;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Embryo;
RX   PubMed=7590333; DOI=10.1016/0378-1119(95)00410-8;
RA   Niemeyer C.C., Foerster-Ziober A., Flytzanis C.N.;
RT   "Purification of a high-mobility-group 1 sea-urchin protein and cloning of
RT   cDNAs.";
RL   Gene 164:211-218(1995).
CC   -!- FUNCTION: Binds preferentially single-stranded DNA and unwinds double-
CC       stranded DNA. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus. Chromosome.
CC   -!- SIMILARITY: Belongs to the HMGB family. {ECO:0000305}.
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DR   EMBL; L06453; AAA91277.1; -; mRNA.
DR   PIR; JC4357; JC4357.
DR   RefSeq; NP_999708.1; NM_214543.1.
DR   AlphaFoldDB; P40644; -.
DR   SMR; P40644; -.
DR   EnsemblMetazoa; NM_214543; NP_999708; GeneID_373332.
DR   GeneID; 373332; -.
DR   KEGG; spu:373332; -.
DR   CTD; 373332; -.
DR   InParanoid; P40644; -.
DR   OMA; GEMWNSK; -.
DR   OrthoDB; 1641977at2759; -.
DR   PhylomeDB; P40644; -.
DR   Proteomes; UP000007110; Unassembled WGS sequence.
DR   GO; GO:0005694; C:chromosome; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0008301; F:DNA binding, bending; IBA:GO_Central.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   Gene3D; 1.10.30.10; -; 2.
DR   InterPro; IPR009071; HMG_box_dom.
DR   InterPro; IPR036910; HMG_box_dom_sf.
DR   Pfam; PF00505; HMG_box; 1.
DR   Pfam; PF09011; HMG_box_2; 1.
DR   SMART; SM00398; HMG; 2.
DR   SUPFAM; SSF47095; SSF47095; 2.
DR   PROSITE; PS50118; HMG_BOX_2; 2.
PE   2: Evidence at transcript level;
KW   Chromosome; DNA-binding; Nucleus; Reference proteome; Repeat.
FT   CHAIN           1..200
FT                   /note="High mobility group protein 1 homolog"
FT                   /id="PRO_0000048545"
FT   DNA_BIND        11..81
FT                   /note="HMG box 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00267"
FT   DNA_BIND        100..168
FT                   /note="HMG box 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00267"
FT   REGION          64..103
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          169..200
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        64..84
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        178..192
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   200 AA;  22834 MW;  5706A90ACEB3B992 CRC64;
     MGKKDRDSSK PRGRMSAYAY FVQDSRAEHG KNHPNSPVRF AEFSKDCSAR WKALEEKGKG
     VFHEKSMRDK VRYDREMQSY KPPKGEKNKR RRRRKDPDAP KRNLSAFFIF SGENRAAIKS
     VHPNWSVGDI AKELAVRWRA MTAGEKIPFD KGAAKDKERY IKAMAEYKAK AKPMKRQVKE
     SSSSSSSDSS SDDSSSDDSD