ID   HMGL_TRYBR              Reviewed;         271 AA.
AC   P26586;
DT   01-AUG-1992, integrated into UniProtKB/Swiss-Prot.
DT   01-AUG-1992, sequence version 1.
DT   03-AUG-2022, entry version 80.
DE   RecName: Full=High mobility group protein homolog TDP-1;
OS   Trypanosoma brucei rhodesiense.
OC   Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC   Trypanosomatida; Trypanosomatidae; Trypanosoma.
OX   NCBI_TaxID=31286;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=WRATat 1.1;
RX   PubMed=1565127; DOI=10.1016/0166-6851(92)90206-y;
RA   Erondu N.E., Donelson J.E.;
RT   "Differential expression of two mRNAs from a single gene encoding an HMG1-
RT   like DNA binding protein of African trypanosomes.";
RL   Mol. Biochem. Parasitol. 51:111-118(1992).
CC   -!- FUNCTION: Unknown. May play a role in transcription and/or DNA
CC       replication. It is not known whether this protein is DNA sequence
CC       binding-specific or not.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00267}.
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DR   EMBL; M74017; AAA73081.1; -; mRNA.
DR   PIR; A45606; A45606.
DR   AlphaFoldDB; P26586; -.
DR   SMR; P26586; -.
DR   PRIDE; P26586; -.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   Gene3D; 1.10.30.10; -; 2.
DR   InterPro; IPR014876; DEK_C.
DR   InterPro; IPR009071; HMG_box_dom.
DR   InterPro; IPR036910; HMG_box_dom_sf.
DR   Pfam; PF08766; DEK_C; 1.
DR   Pfam; PF00505; HMG_box; 2.
DR   SMART; SM00398; HMG; 2.
DR   SUPFAM; SSF47095; SSF47095; 2.
DR   PROSITE; PS51998; DEK_C; 1.
DR   PROSITE; PS50118; HMG_BOX_2; 2.
PE   2: Evidence at transcript level;
KW   DNA-binding; Nucleus; Repeat.
FT   CHAIN           1..271
FT                   /note="High mobility group protein homolog TDP-1"
FT                   /id="PRO_0000048563"
FT   DOMAIN          8..63
FT                   /note="DEK-C"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01342"
FT   DNA_BIND        118..186
FT                   /note="HMG box 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00267"
FT   DNA_BIND        206..270
FT                   /note="HMG box 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00267"
FT   REGION          75..118
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        97..116
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   271 AA;  30866 MW;  0B2ED4B7317A5802 CRC64;
     MATELKKGPL PTDIEETVIT IMREEGVRYI TAKILRMRLE SKYQMEFGPH KAAIDDIVAR
     AMQRPEFKKQ LELALKEKDA SKSSGGKGSK RARSAGAEAP SKTKKEMTEK PKKPADYPKP
     AVSSYLLFVA DQREELKAKN PGMQNTAILQ TLGKMWSDAS DDVKEHYRKK AEEDKARFRR
     EVDEYKRQGG KEYGRGGKIK KDSNAPKRAM TSFMFFSSDF RSKHSDLSIV EMSKAAGAAW
     KELGPEERKV YEEMAEKDKE RYKREMAALP K