HMGN2_CHICK
ID HMGN2_CHICK Reviewed; 90 AA.
AC P02314;
DT 21-JUL-1986, integrated into UniProtKB/Swiss-Prot.
DT 23-JAN-2007, sequence version 3.
DT 03-AUG-2022, entry version 114.
DE RecName: Full=Non-histone chromosomal protein HMG-17;
DE AltName: Full=High mobility group nucleosome-binding domain-containing protein 2;
GN Name=HMGN2; Synonyms=HMG17;
OS Gallus gallus (Chicken).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC Phasianinae; Gallus.
OX NCBI_TaxID=9031;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=3628013; DOI=10.1093/nar/15.16.6750;
RA Landsman D., Bustin M.;
RT "Chicken non-histone chromosomal protein HMG-17 cDNA sequence.";
RL Nucleic Acids Res. 15:6750-6750(1987).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=3384337; DOI=10.1016/0378-1119(88)90532-x;
RA Dodgson J.B., Browne D.L., Black A.J.;
RT "Chicken chromosomal protein HMG-14 and HMG-17 cDNA clones: isolation,
RT characterization and sequence comparison.";
RL Gene 63:287-295(1988).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=2831214; DOI=10.1016/s0021-9258(18)69013-1;
RA Landsman D., Srikantha T., Bustin M.;
RT "Single copy gene for the chicken non-histone chromosomal protein HMG-17.";
RL J. Biol. Chem. 263:3917-3923(1988).
RN [4]
RP PROTEIN SEQUENCE OF 2-39.
RX PubMed=7396821; DOI=10.1042/bj1850383;
RA Walker J.M., Johns E.W.;
RT "The isolation, characterization and partial sequences of the chicken
RT erythrocyte non-histone chromosomal proteins HMG14 and HMG17. Comparison
RT with the homologous calf thymus proteins.";
RL Biochem. J. 185:383-386(1980).
RN [5]
RP PROTEIN SEQUENCE OF 29-90.
RX PubMed=7371857; DOI=10.1016/0014-5793(80)80181-5;
RA Walker J.M., Stearn C., Johns E.W.;
RT "The primary structure of non-histone chromosomal protein HMG17 from
RT chicken erythrocyte nuclei.";
RL FEBS Lett. 112:207-210(1980).
CC -!- FUNCTION: Binds to the inner side of the nucleosomal DNA thus altering
CC the interaction between the DNA and the histone octamer. May be
CC involved in the process which maintains transcribable genes in a unique
CC chromatin conformation.
CC -!- SUBCELLULAR LOCATION: Nucleus.
CC -!- SIMILARITY: Belongs to the HMGN family. {ECO:0000305}.
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DR EMBL; Y00416; CAA68473.1; -; mRNA.
DR EMBL; M26676; AAA48817.1; -; mRNA.
DR EMBL; J03229; AAA48816.1; -; Genomic_DNA.
DR PIR; A29951; NSCHH7.
DR RefSeq; NP_001072953.1; NM_001079485.1.
DR AlphaFoldDB; P02314; -.
DR STRING; 9031.ENSGALP00000000503; -.
DR PaxDb; P02314; -.
DR PRIDE; P02314; -.
DR Ensembl; ENSGALT00000056521; ENSGALP00000045393; ENSGALG00000032207.
DR GeneID; 768675; -.
DR KEGG; gga:768675; -.
DR CTD; 10473; -.
DR VEuPathDB; HostDB:geneid_768675; -.
DR eggNOG; ENOG502S5FK; Eukaryota.
DR GeneTree; ENSGT00950000182802; -.
DR HOGENOM; CLU_141985_0_2_1; -.
DR InParanoid; P02314; -.
DR OMA; SARLSAX; -.
DR PhylomeDB; P02314; -.
DR PRO; PR:P02314; -.
DR Proteomes; UP000000539; Chromosome 23.
DR Bgee; ENSGALG00000032207; Expressed in spermatid and 12 other tissues.
DR GO; GO:0000785; C:chromatin; IEA:InterPro.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0003682; F:chromatin binding; IBA:GO_Central.
DR GO; GO:0031492; F:nucleosomal DNA binding; IEA:InterPro.
DR GO; GO:0006325; P:chromatin organization; IBA:GO_Central.
DR InterPro; IPR000079; HMGN_fam.
DR Pfam; PF01101; HMG14_17; 1.
DR PRINTS; PR00925; NONHISHMG17.
DR SMART; SM00527; HMG17; 1.
DR PROSITE; PS00355; HMG14_17; 1.
PE 1: Evidence at protein level;
KW Direct protein sequencing; DNA-binding; Nucleus; Reference proteome.
FT INIT_MET 1
FT /note="Removed"
FT /evidence="ECO:0000269|PubMed:7396821"
FT CHAIN 2..90
FT /note="Non-histone chromosomal protein HMG-17"
FT /id="PRO_0000206702"
FT REGION 1..90
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..26
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 81
FT /note="Q -> E (in Ref. 5; AA sequence)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 90 AA; 9453 MW; C1BF6EBC2AE4C399 CRC64;
MPKRKAEGDT KGDKAKVKDE PQRRSARLSA KPAPPKPEPK PKKAAPKKSE KVPKGKKGKA
DAGKEGNNPA ENGDAKTDQA QKAEGAGDAK
