ID   HMGN3_RAT               Reviewed;          95 AA.
AC   Q66H40;
DT   18-APR-2006, integrated into UniProtKB/Swiss-Prot.
DT   11-OCT-2004, sequence version 1.
DT   03-AUG-2022, entry version 105.
DE   RecName: Full=High mobility group nucleosome-binding domain-containing protein 3;
GN   Name=Hmgn3;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Kidney;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [2]
RP   PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-6, AND IDENTIFICATION BY MASS
RP   SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=22673903; DOI=10.1038/ncomms1871;
RA   Lundby A., Secher A., Lage K., Nordsborg N.B., Dmytriyev A., Lundby C.,
RA   Olsen J.V.;
RT   "Quantitative maps of protein phosphorylation sites across 14 different rat
RT   organs and tissues.";
RL   Nat. Commun. 3:876-876(2012).
CC   -!- FUNCTION: Binds to nucleosomes, regulating chromatin structure and
CC       consequently, chromatin-dependent processes such as transcription, DNA
CC       replication and DNA repair. Affects both insulin and glucagon levels
CC       and modulates the expression of pancreatic genes involved in insulin
CC       secretion. Regulates the expression of the glucose transporter SLC2A2
CC       by binding specifically to its promoter region and recruiting PDX1 and
CC       additional transcription factors. Regulates the expression of SLC6A9, a
CC       glycine transporter which regulates the glycine concentration in
CC       synaptic junctions in the central nervous system, by binding to its
CC       transcription start site. May play a role in ocular development and
CC       astrocyte function (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with the ligand binding domain of the thyroid
CC       receptor (TR) (in vitro). Requires the presence of thyroid hormone for
CC       its interaction. Interacts with transcriptional regulator SEHBP.
CC       Interacts with nucleosomes. {ECO:0000250|UniProtKB:Q15651}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the HMGN family. {ECO:0000305}.
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DR   EMBL; BC082036; AAH82036.1; -; mRNA.
DR   RefSeq; NP_001007021.1; NM_001007020.2.
DR   RefSeq; NP_001188282.1; NM_001201353.1.
DR   RefSeq; NP_001188283.1; NM_001201354.1.
DR   RefSeq; NP_001188284.1; NM_001201355.1.
DR   AlphaFoldDB; Q66H40; -.
DR   BioGRID; 250246; 2.
DR   STRING; 10116.ENSRNOP00000066015; -.
DR   iPTMnet; Q66H40; -.
DR   PhosphoSitePlus; Q66H40; -.
DR   PaxDb; Q66H40; -.
DR   GeneID; 113990; -.
DR   KEGG; rno:113990; -.
DR   UCSC; RGD:1359106; rat.
DR   CTD; 9324; -.
DR   RGD; 1359106; Hmgn3.
DR   eggNOG; ENOG502S60V; Eukaryota.
DR   InParanoid; Q66H40; -.
DR   OrthoDB; 1617797at2759; -.
DR   PhylomeDB; Q66H40; -.
DR   PRO; PR:Q66H40; -.
DR   Proteomes; UP000002494; Chromosome 8.
DR   Bgee; ENSRNOG00000031032; Expressed in cerebellum and 20 other tissues.
DR   ExpressionAtlas; Q66H40; baseline and differential.
DR   Genevisible; Q66H40; RN.
DR   GO; GO:0000785; C:chromatin; IEA:InterPro.
DR   GO; GO:0005634; C:nucleus; ISO:RGD.
DR   GO; GO:0003682; F:chromatin binding; ISO:RGD.
DR   GO; GO:0031492; F:nucleosomal DNA binding; IEA:InterPro.
DR   GO; GO:0006325; P:chromatin organization; IBA:GO_Central.
DR   GO; GO:0051091; P:positive regulation of DNA-binding transcription factor activity; ISO:RGD.
DR   GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; ISO:RGD.
DR   GO; GO:0061178; P:regulation of insulin secretion involved in cellular response to glucose stimulus; ISO:RGD.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; ISO:RGD.
DR   InterPro; IPR031073; HMGN3.
DR   InterPro; IPR000079; HMGN_fam.
DR   PANTHER; PTHR23087:SF2; PTHR23087:SF2; 1.
DR   Pfam; PF01101; HMG14_17; 1.
DR   PRINTS; PR00925; NONHISHMG17.
DR   SMART; SM00527; HMG17; 1.
DR   PROSITE; PS00355; HMG14_17; 1.
PE   1: Evidence at protein level;
KW   Chromatin regulator; DNA-binding; Nucleus; Phosphoprotein;
KW   Reference proteome.
FT   CHAIN           1..95
FT                   /note="High mobility group nucleosome-binding domain-
FT                   containing protein 3"
FT                   /id="PRO_0000232577"
FT   REGION          1..95
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..27
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        38..72
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         6
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0007744|PubMed:22673903"
FT   MOD_RES         78
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q15651"
SQ   SEQUENCE   95 AA;  10183 MW;  FCC76474258624B7 CRC64;
     MPKRKSPENA EGKDGAKLTK QEPTRRSARL SAKPVPPKPE PKPRKTSAKK EPGTKINRAA
     KGKKEEKQEA GKEGTAPSAN GDTKAEEVLS TNASH