HMGT_ONCMY
ID HMGT_ONCMY Reviewed; 204 AA.
AC P07746; Q91200;
DT 01-AUG-1988, integrated into UniProtKB/Swiss-Prot.
DT 01-JUL-1989, sequence version 2.
DT 25-MAY-2022, entry version 98.
DE RecName: Full=High mobility group-T protein;
DE Short=HMG-T;
DE AltName: Full=HMG-T1;
DE Short=HMG-1;
OS Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Salmoniformes;
OC Salmonidae; Salmoninae; Oncorhynchus.
OX NCBI_TaxID=8022;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=4022777; DOI=10.1093/nar/13.13.4871;
RA Pentecost B.T., Wright J.M., Dixon G.H.;
RT "Isolation and sequence of cDNA clones coding for a member of the family of
RT high mobility group proteins (HMG-T) in trout and analysis of HMG-T-mRNA's
RT in trout tissues.";
RL Nucleic Acids Res. 13:4871-4888(1985).
RN [2]
RP SEQUENCE REVISION.
RA Wright J.;
RL Submitted (MAY-1986) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC TISSUE=Testis;
RX PubMed=7957172; DOI=10.1111/j.1432-1033.1994.00581.x;
RA Stros M., Nishikawa S., Dixon G.H.;
RT "cDNA sequence and structure of a gene encoding trout testis high-mobility-
RT group-1 protein.";
RL Eur. J. Biochem. 225:581-591(1994).
CC -!- FUNCTION: Binds preferentially single-stranded DNA and unwinds double-
CC stranded DNA.
CC -!- SUBCELLULAR LOCATION: Nucleus. Chromosome.
CC -!- SIMILARITY: Belongs to the HMGB family. {ECO:0000305}.
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DR EMBL; X02666; CAA26500.1; -; mRNA.
DR EMBL; L32859; AAA58771.1; -; Genomic_DNA.
DR PIR; A24019; A24019.
DR PIR; T01071; T01071.
DR RefSeq; NP_001118186.1; NM_001124714.1.
DR AlphaFoldDB; P07746; -.
DR SMR; P07746; -.
DR GeneID; 100136765; -.
DR KEGG; omy:100136765; -.
DR CTD; 321622; -.
DR GO; GO:0000785; C:chromatin; IDA:CAFA.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003690; F:double-stranded DNA binding; IDA:CAFA.
DR DisProt; DP00041; -.
DR Gene3D; 1.10.30.10; -; 2.
DR InterPro; IPR009071; HMG_box_dom.
DR InterPro; IPR036910; HMG_box_dom_sf.
DR InterPro; IPR017967; HMG_boxA_CS.
DR Pfam; PF00505; HMG_box; 1.
DR Pfam; PF09011; HMG_box_2; 1.
DR SMART; SM00398; HMG; 2.
DR SUPFAM; SSF47095; SSF47095; 2.
DR PROSITE; PS00353; HMG_BOX_1; 1.
DR PROSITE; PS50118; HMG_BOX_2; 2.
PE 2: Evidence at transcript level;
KW Chromosome; DNA-binding; Nucleus; Repeat.
FT CHAIN 1..204
FT /note="High mobility group-T protein"
FT /id="PRO_0000048544"
FT DNA_BIND 8..78
FT /note="HMG box 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00267"
FT DNA_BIND 94..162
FT /note="HMG box 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00267"
FT REGION 162..204
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 181..204
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 22
FT /note="R -> C (in Ref. 3; AAA58771)"
FT /evidence="ECO:0000305"
FT CONFLICT 149
FT /note="R -> K (in Ref. 3; AAA58771)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 204 AA; 23572 MW; 6A858A144AD669A0 CRC64;
MGKDPRKPRG KMSSYAYFVQ TRREEHKKKH PEASVNFSEF SKKCSERWKT MSAKEKGKFE
DLAKLDKVRY EREMRSYIPP KGEKKKRFKD PNAPKRPSSA FFIFCADFRP QVKGETPGLS
IGDVAKKLGE KWNNLTAEDK VPYEKKASRL KEKYEKDITA YRNKGKVPVS MPAKAAAPAK
DDDDDDDDDD DDEDDDDDDD EDDE