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HMGT_ONCMY
ID   HMGT_ONCMY              Reviewed;         204 AA.
AC   P07746; Q91200;
DT   01-AUG-1988, integrated into UniProtKB/Swiss-Prot.
DT   01-JUL-1989, sequence version 2.
DT   25-MAY-2022, entry version 98.
DE   RecName: Full=High mobility group-T protein;
DE            Short=HMG-T;
DE   AltName: Full=HMG-T1;
DE            Short=HMG-1;
OS   Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Salmoniformes;
OC   Salmonidae; Salmoninae; Oncorhynchus.
OX   NCBI_TaxID=8022;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=4022777; DOI=10.1093/nar/13.13.4871;
RA   Pentecost B.T., Wright J.M., Dixon G.H.;
RT   "Isolation and sequence of cDNA clones coding for a member of the family of
RT   high mobility group proteins (HMG-T) in trout and analysis of HMG-T-mRNA's
RT   in trout tissues.";
RL   Nucleic Acids Res. 13:4871-4888(1985).
RN   [2]
RP   SEQUENCE REVISION.
RA   Wright J.;
RL   Submitted (MAY-1986) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   TISSUE=Testis;
RX   PubMed=7957172; DOI=10.1111/j.1432-1033.1994.00581.x;
RA   Stros M., Nishikawa S., Dixon G.H.;
RT   "cDNA sequence and structure of a gene encoding trout testis high-mobility-
RT   group-1 protein.";
RL   Eur. J. Biochem. 225:581-591(1994).
CC   -!- FUNCTION: Binds preferentially single-stranded DNA and unwinds double-
CC       stranded DNA.
CC   -!- SUBCELLULAR LOCATION: Nucleus. Chromosome.
CC   -!- SIMILARITY: Belongs to the HMGB family. {ECO:0000305}.
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DR   EMBL; X02666; CAA26500.1; -; mRNA.
DR   EMBL; L32859; AAA58771.1; -; Genomic_DNA.
DR   PIR; A24019; A24019.
DR   PIR; T01071; T01071.
DR   RefSeq; NP_001118186.1; NM_001124714.1.
DR   AlphaFoldDB; P07746; -.
DR   SMR; P07746; -.
DR   GeneID; 100136765; -.
DR   KEGG; omy:100136765; -.
DR   CTD; 321622; -.
DR   GO; GO:0000785; C:chromatin; IDA:CAFA.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003690; F:double-stranded DNA binding; IDA:CAFA.
DR   DisProt; DP00041; -.
DR   Gene3D; 1.10.30.10; -; 2.
DR   InterPro; IPR009071; HMG_box_dom.
DR   InterPro; IPR036910; HMG_box_dom_sf.
DR   InterPro; IPR017967; HMG_boxA_CS.
DR   Pfam; PF00505; HMG_box; 1.
DR   Pfam; PF09011; HMG_box_2; 1.
DR   SMART; SM00398; HMG; 2.
DR   SUPFAM; SSF47095; SSF47095; 2.
DR   PROSITE; PS00353; HMG_BOX_1; 1.
DR   PROSITE; PS50118; HMG_BOX_2; 2.
PE   2: Evidence at transcript level;
KW   Chromosome; DNA-binding; Nucleus; Repeat.
FT   CHAIN           1..204
FT                   /note="High mobility group-T protein"
FT                   /id="PRO_0000048544"
FT   DNA_BIND        8..78
FT                   /note="HMG box 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00267"
FT   DNA_BIND        94..162
FT                   /note="HMG box 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00267"
FT   REGION          162..204
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        181..204
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CONFLICT        22
FT                   /note="R -> C (in Ref. 3; AAA58771)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        149
FT                   /note="R -> K (in Ref. 3; AAA58771)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   204 AA;  23572 MW;  6A858A144AD669A0 CRC64;
     MGKDPRKPRG KMSSYAYFVQ TRREEHKKKH PEASVNFSEF SKKCSERWKT MSAKEKGKFE
     DLAKLDKVRY EREMRSYIPP KGEKKKRFKD PNAPKRPSSA FFIFCADFRP QVKGETPGLS
     IGDVAKKLGE KWNNLTAEDK VPYEKKASRL KEKYEKDITA YRNKGKVPVS MPAKAAAPAK
     DDDDDDDDDD DDEDDDDDDD EDDE
 
 
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