HMGX3_HUMAN
ID HMGX3_HUMAN Reviewed; 1292 AA.
AC Q12766; G5E9Y4; Q86UG3; Q9UMF4;
DT 01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT 29-SEP-2021, sequence version 3.
DT 03-AUG-2022, entry version 151.
DE RecName: Full=HMG domain-containing protein 3 {ECO:0000305};
DE AltName: Full=HMG box-containing protein 3;
DE AltName: Full=Protein SMF;
GN Name=HMGXB3 {ECO:0000312|HGNC:HGNC:28982};
GN Synonyms=KIAA0194 {ECO:0000303|PubMed:8724849}, SMF;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Bone marrow;
RX PubMed=8724849; DOI=10.1093/dnares/3.1.17;
RA Nagase T., Seki N., Ishikawa K., Tanaka A., Nomura N.;
RT "Prediction of the coding sequences of unidentified human genes. V. The
RT coding sequences of 40 new genes (KIAA0161-KIAA0200) deduced by analysis of
RT cDNA clones from human cell line KG-1.";
RL DNA Res. 3:17-24(1996).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15372022; DOI=10.1038/nature02919;
RA Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S.,
RA Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M.,
RA She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S.,
RA Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M.,
RA Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T., Gomez M.,
RA Gonzales E., Goodstein D., Grigoriev I., Groza M., Hammon N., Hawkins T.,
RA Haydu L., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A.,
RA Lopez F., Lou Y., Martinez D., Medina C., Morgan J., Nandkeshwar R.,
RA Noonan J.P., Pitluck S., Pollard M., Predki P., Priest J., Ramirez L.,
RA Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., Thayer N.,
RA Tice H., Tsai M., Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J.,
RA Dickson M., Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A.,
RA Rokhsar D.S., Richardson P., Lucas S.M., Myers R.M., Rubin E.M.;
RT "The DNA sequence and comparative analysis of human chromosome 5.";
RL Nature 431:268-274(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 915-1292.
RC TISSUE=Placenta;
RX PubMed=9027509; DOI=10.1006/geno.1996.4482;
RA Andre C., Hampe A., Lachaume P., Martin E., Wang X.P., Manus V., Hu W.X.,
RA Galibert F.;
RT "Sequence analysis of two genomic regions containing the KIT and the FMS
RT receptor tyrosine kinase genes.";
RL Genomics 39:216-226(1997).
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00267}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAH51025.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
CC Sequence=BAA12107.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
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DR EMBL; D83778; BAA12107.1; ALT_INIT; mRNA.
DR EMBL; AC011406; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471062; EAW61752.1; -; Genomic_DNA.
DR EMBL; BC051025; AAH51025.1; ALT_INIT; mRNA.
DR EMBL; U63963; AAB51697.1; -; Genomic_DNA.
DR CCDS; CCDS54935.1; -.
DR AlphaFoldDB; Q12766; -.
DR SMR; Q12766; -.
DR BioGRID; 116640; 6.
DR IntAct; Q12766; 8.
DR MINT; Q12766; -.
DR STRING; 9606.ENSP00000421917; -.
DR iPTMnet; Q12766; -.
DR PhosphoSitePlus; Q12766; -.
DR BioMuta; HMGXB3; -.
DR DMDM; 160112910; -.
DR EPD; Q12766; -.
DR jPOST; Q12766; -.
DR MassIVE; Q12766; -.
DR MaxQB; Q12766; -.
DR PaxDb; Q12766; -.
DR PeptideAtlas; Q12766; -.
DR PRIDE; Q12766; -.
DR ProteomicsDB; 34082; -.
DR Antibodypedia; 1181; 95 antibodies from 21 providers.
DR DNASU; 22993; -.
DR Ensembl; ENST00000502717.6; ENSP00000421917.1; ENSG00000113716.13.
DR GeneID; 22993; -.
DR MANE-Select; ENST00000502717.6; ENSP00000421917.1; NM_014983.3; NP_055798.3.
DR UCSC; uc003lrk.5; human.
DR CTD; 22993; -.
DR DisGeNET; 22993; -.
DR GeneCards; HMGXB3; -.
DR HGNC; HGNC:28982; HMGXB3.
DR HPA; ENSG00000113716; Tissue enriched (parathyroid).
DR MIM; 619800; gene.
DR neXtProt; NX_Q12766; -.
DR OpenTargets; ENSG00000113716; -.
DR PharmGKB; PA164720627; -.
DR VEuPathDB; HostDB:ENSG00000113716; -.
DR eggNOG; ENOG502QZFJ; Eukaryota.
DR GeneTree; ENSGT00390000006983; -.
DR InParanoid; Q12766; -.
DR OrthoDB; 188302at2759; -.
DR PhylomeDB; Q12766; -.
DR TreeFam; TF330893; -.
DR PathwayCommons; Q12766; -.
DR SignaLink; Q12766; -.
DR BioGRID-ORCS; 22993; 38 hits in 1108 CRISPR screens.
DR ChiTaRS; HMGXB3; human.
DR GenomeRNAi; 22993; -.
DR Pharos; Q12766; Tdark.
DR PRO; PR:Q12766; -.
DR Proteomes; UP000005640; Chromosome 5.
DR RNAct; Q12766; protein.
DR ExpressionAtlas; Q12766; baseline and differential.
DR Genevisible; Q12766; HS.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR Gene3D; 1.10.30.10; -; 1.
DR InterPro; IPR009071; HMG_box_dom.
DR InterPro; IPR036910; HMG_box_dom_sf.
DR InterPro; IPR039598; HMGXB3.
DR InterPro; IPR040648; HMGXB3_CxC4.
DR PANTHER; PTHR17609; PTHR17609; 1.
DR Pfam; PF18717; CxC4; 1.
DR Pfam; PF09011; HMG_box_2; 1.
DR SMART; SM00398; HMG; 1.
DR SUPFAM; SSF47095; SSF47095; 1.
DR PROSITE; PS50118; HMG_BOX_2; 1.
PE 2: Evidence at transcript level;
KW DNA-binding; Nucleus; Reference proteome.
FT CHAIN 1..1292
FT /note="HMG domain-containing protein 3"
FT /id="PRO_0000048806"
FT DNA_BIND 42..110
FT /note="HMG box"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00267"
FT REGION 363..391
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 448..505
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 562..588
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 364..391
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 450..481
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 488
FT /note="A -> V (in Ref. 3; AAH51025 and 4; BAA12107)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 1292 AA; 141106 MW; 2C390765939C81E3 CRC64;
MDASYDGTEV TVVMEEIEEA YCYTSPGPPK KKKKYKIHGE KTKKPRSAYL LYYYDIYLKV
QQELPHLPQS EINKKISESW RLLSVAERSY YLEKAKLEKE GLDPNSKLSA LTAVVPDIPG
FRKILPRSDY IIIPKSSLQE DRSCPQLELC VAQNQMSPKG PPLVSNTAPE TVPSHAGMAE
QCLAVEALAE EVGALTQSGA VQEIATSEIL SQDVLLEDAS LEVGESHQPY QTSLVIEETL
VNGSPDLPTG SLAVPHPQVG ESVSVVTVMR DSSESSSSAP ATQFIMLPLP AYSVVENPTS
IKLTTTYTRR GHGTCTSPGC SFTYVTRHKP PKCPTCGNFL GGKWIPKEKP AKVKVELASG
VSSKGSVVKR NQQPVTTEQN SSKENASKLT LENSEAVSQL LNVAPPREVG EESEWEEVII
SDAHVLVKEA PGNCGTAVTK TPVVKSGVQP EVTLGTTDND SPGADVPTPS EGTSTSSPLP
APKKPTGADL LTPGSRAPEL KGRARGKPSL LAAARPMRAI LPAPVNVGRG SSMGLPRARQ
AFSLSDKTPS VRTCGLKPST LKQLGQPIQQ PSGPGEVKLP SGPSNRTSQV KVVEVKPDMF
PPYKYSCTVT LDLGLATSRG RGKCKNPSCS YVYTNRHKPR ICPSCGVNLA KDRTEKTTKA
IEVSSPLPDV LNATEPLSTA QREIQRQSTL QLLRKVLQIP ENESELAEVF ALIHELNSSR
LILSNVSEET VTIEQTSWSN YYESPSTQCL LCSSPLFKGG QNSLAGPQEC WLLTASRLQT
VTAQVKMCLN PHCLALHSFI DIYTGLFNVG NKLLVSLDLL FAIRNQIKLG EDPRVSINVV
LKSVQEQTEK TLTSEELSQL QELLCNGYWA FECLTVRDYN DMICGICGVA PKVEMAQRSE
ENVLALKSVE FTWPEFLGSN EVNVEDFWAT METEVIEQVA FPASIPITKF DASVIAPFFP
PLMRGAVVVN TEKDKNLDVQ PVPGSGSALV RLLQEGTCKL DEIGSYSEEK LQHLLRQCGI
PFGAEDSKDQ LCFSLLALYE SVQNGARAIR PPRHFTGGKI YKVCPHQVVC GSKYLVRGES
ARDHVDLLAS SRHWPPVYVV DMATSVALCA DLCYPELTNQ MWGRNQGCFS SPTEPPVSVS
CPELLDQHYT VDMTETEHSI QHPVTKTATR RIVHAGLQPN PGDPSAGHHS LALCPELAPY
ATILASIVDS KPNGVRQRPI AFDNATHYYL YNRLMDFLTS REIVNRQIHD IVQSCQPGEV
VIRDTLYRLG VAQIKTETEE EGEEEEVAAV AE
