HMGX4_XENLA
ID HMGX4_XENLA Reviewed; 554 AA.
AC Q6WKW9;
DT 14-APR-2009, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 03-AUG-2022, entry version 78.
DE RecName: Full=HMG box-containing protein 4;
DE AltName: Full=High mobility group protein 2-like 1 {ECO:0000303|PubMed:12875653};
DE Short=xHMG2L1 {ECO:0000303|PubMed:12875653};
GN Name=hmgxb4; Synonyms=hmg2l1 {ECO:0000312|EMBL:AAP92714.1};
OS Xenopus laevis (African clawed frog).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX NCBI_TaxID=8355;
RN [1] {ECO:0000305, ECO:0000312|EMBL:AAP92714.1}
RP NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, INTERACTION WITH NLK.2, AND
RP DEVELOPMENTAL STAGE.
RC TISSUE=Oocyte {ECO:0000269|PubMed:12875653};
RX PubMed=12875653; DOI=10.1046/j.1365-2443.2003.00666.x;
RA Yamada M., Ohkawara B., Ichimura N., Hyodo-Miura J., Urushiyama S.,
RA Shirakabe K., Shibuya H.;
RT "Negative regulation of Wnt signalling by HMG2L1, a novel NLK-binding
RT protein.";
RL Genes Cells 8:677-684(2003).
CC -!- FUNCTION: Negatively regulates Wnt/beta-catenin signaling during
CC development. {ECO:0000269|PubMed:12875653}.
CC -!- SUBUNIT: Interacts with nlk.2. {ECO:0000269|PubMed:12875653}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00267}.
CC -!- DEVELOPMENTAL STAGE: Expressed both maternally and zygotically. Widely
CC expressed at the early gastrula stage. Expressed throughout early
CC embryogenesis until at least the tadpole stage.
CC {ECO:0000269|PubMed:12875653}.
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DR EMBL; AY281348; AAP92714.1; -; mRNA.
DR RefSeq; NP_001082746.1; NM_001089277.1.
DR AlphaFoldDB; Q6WKW9; -.
DR SMR; Q6WKW9; -.
DR MaxQB; Q6WKW9; -.
DR PRIDE; Q6WKW9; -.
DR GeneID; 398700; -.
DR KEGG; xla:398700; -.
DR CTD; 398700; -.
DR Xenbase; XB-GENE-951787; hmgxb4.S.
DR OrthoDB; 1641977at2759; -.
DR Proteomes; UP000186698; Chromosome 4S.
DR Bgee; 398700; Expressed in egg cell and 19 other tissues.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0019901; F:protein kinase binding; IPI:UniProtKB.
DR GO; GO:0030178; P:negative regulation of Wnt signaling pathway; IMP:UniProtKB.
DR GO; GO:0016055; P:Wnt signaling pathway; IEA:UniProtKB-KW.
DR Gene3D; 1.10.30.10; -; 1.
DR InterPro; IPR025228; DUF4171.
DR InterPro; IPR009071; HMG_box_dom.
DR InterPro; IPR036910; HMG_box_dom_sf.
DR InterPro; IPR042477; HMGXB4.
DR PANTHER; PTHR46584; PTHR46584; 1.
DR Pfam; PF13775; DUF4171; 1.
DR Pfam; PF00505; HMG_box; 1.
DR SMART; SM00398; HMG; 1.
DR SUPFAM; SSF47095; SSF47095; 1.
DR PROSITE; PS50118; HMG_BOX_2; 1.
PE 1: Evidence at protein level;
KW Developmental protein; DNA-binding; Nucleus; Reference proteome;
KW Wnt signaling pathway.
FT CHAIN 1..554
FT /note="HMG box-containing protein 4"
FT /id="PRO_0000370233"
FT DNA_BIND 359..427
FT /note="HMG box"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00267"
FT REGION 15..368
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 417..469
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 23..93
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 94..122
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 145..176
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 209..228
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 270..295
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 311..332
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 342..361
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 417..468
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 554 AA; 60910 MW; A2DF64DCA5532F36 CRC64;
MSYRDLRECI DLERGTEDVG LAAGRSQREK KRSYKDLLRE EEEIAEQVRK SSKKRSKELD
LFSGNELHKK KKKHSSDDYH ADHSTDSAKK KKKTSLPSPS SSDTAMDLLK AITSPQADTS
TTHPSKKPEK ILATPISFSS PSQPPHKDYH KKSGEVSGDD SSHRSKKSKP LTLREPDGLR
MKLIMSPNEK SEEEAVSPQG GPGHSDSASS KKNSKKLGRE EIESRSSHKK HKKQSYTPRS
GGTPDSASST GGELDAGELV IDDSLRDMKK KKKSKKSKKK KDKHKDEKHK KHSKSKREHE
VEQSQTQIAS PGLPSPPPPP ATTPPTSPPS IPLQPQALVT HTEEQSDKKK KKEDPEKPKK
KNMSAYQVFS KEYRVSIIAE HPGIDFGELS KKLAEVWKQL PEKDKLVWKQ KAQYLQHKQN
KAEATTVKRK SSSSESAPKS KGSSSGLVSP NKKSPTSSVA SFSTSPAKVP DTEPIDVAAH
LQLLGESLSL IGHRLQETEG MVAVSGSLSV LLDSILCALG PLVCLTSHVP QLNACPKQIL
SNTLDNIAYV MPGL
