ID   HMGX4_XENTR             Reviewed;         554 AA.
AC   Q5BL56;
DT   14-APR-2009, integrated into UniProtKB/Swiss-Prot.
DT   12-APR-2005, sequence version 1.
DT   03-AUG-2022, entry version 89.
DE   RecName: Full=HMG box-containing protein 4;
DE   AltName: Full=High mobility group protein 2-like 1;
GN   Name=hmgxb4;
GN   Synonyms=hmg2l1 {ECO:0000312|EMBL:CAJ82282.1},
GN   hmgb2l1 {ECO:0000312|EMBL:AAH90595.1}; ORFNames=TEgg141c05.1;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1] {ECO:0000312|EMBL:CAJ82282.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Egg {ECO:0000312|EMBL:CAJ82282.1};
RG   Sanger Xenopus tropicalis EST/cDNA project;
RL   Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000312|EMBL:CAJ82282.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Tail bud {ECO:0000312|EMBL:AAH90595.1};
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (FEB-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Negatively regulates Wnt/beta-catenin signaling during
CC       development. {ECO:0000250|UniProtKB:Q6WKW9}.
CC   -!- SUBUNIT: Interacts with nlk.2. {ECO:0000250|UniProtKB:Q6WKW9}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00267}.
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DR   EMBL; CR760909; CAJ82282.1; -; mRNA.
DR   EMBL; BC090595; AAH90595.1; -; mRNA.
DR   RefSeq; NP_001025555.1; NM_001030384.1.
DR   RefSeq; XP_012816665.1; XM_012961211.2.
DR   AlphaFoldDB; Q5BL56; -.
DR   SMR; Q5BL56; -.
DR   STRING; 8364.ENSXETP00000013886; -.
DR   PaxDb; Q5BL56; -.
DR   DNASU; 594948; -.
DR   Ensembl; ENSXETT00000013886; ENSXETP00000013886; ENSXETG00000006340.
DR   GeneID; 594948; -.
DR   KEGG; xtr:594948; -.
DR   CTD; 10042; -.
DR   Xenbase; XB-GENE-951781; hmgxb4.
DR   eggNOG; ENOG502QSH9; Eukaryota.
DR   InParanoid; Q5BL56; -.
DR   OrthoDB; 1641977at2759; -.
DR   Proteomes; UP000008143; Chromosome 4.
DR   Proteomes; UP000790000; Unplaced.
DR   Bgee; ENSXETG00000006340; Expressed in 4-cell stage embryo and 12 other tissues.
DR   ExpressionAtlas; Q5BL56; baseline.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0019901; F:protein kinase binding; ISS:UniProtKB.
DR   GO; GO:0030178; P:negative regulation of Wnt signaling pathway; ISS:UniProtKB.
DR   GO; GO:0016055; P:Wnt signaling pathway; IEA:UniProtKB-KW.
DR   Gene3D; 1.10.30.10; -; 1.
DR   InterPro; IPR025228; DUF4171.
DR   InterPro; IPR009071; HMG_box_dom.
DR   InterPro; IPR036910; HMG_box_dom_sf.
DR   InterPro; IPR042477; HMGXB4.
DR   PANTHER; PTHR46584; PTHR46584; 1.
DR   Pfam; PF13775; DUF4171; 1.
DR   Pfam; PF00505; HMG_box; 1.
DR   SMART; SM00398; HMG; 1.
DR   SUPFAM; SSF47095; SSF47095; 1.
DR   PROSITE; PS50118; HMG_BOX_2; 1.
PE   2: Evidence at transcript level;
KW   Developmental protein; DNA-binding; Nucleus; Reference proteome;
KW   Wnt signaling pathway.
FT   CHAIN           1..554
FT                   /note="HMG box-containing protein 4"
FT                   /id="PRO_0000370234"
FT   DNA_BIND        360..428
FT                   /note="HMG box"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00267"
FT   REGION          14..34
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          47..368
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          418..468
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        47..94
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        101..126
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        148..180
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        213..232
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        274..299
FT                   /note="Basic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        314..335
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        343..362
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   554 AA;  60907 MW;  3600304B93929CB9 CRC64;
     MSFRDLRECI DSERGMEDVG LAAGRSQREK KRSYKDLLRE EEEIAEQVRK SSKKRSRELD
     LFLASESHKK KKKHLTDDYH ADTPSPDLAK KKKKALLPSP APPSSSDTAM DLLKAITSPQ
     VDTSTTHLPK KPEKILATPV NFSSPSQSSH KEHHKKIGEV SGDDSSHRSK KSKPLTLREP
     DGLRMKLILS PNEKSEEESA SPQGGPGHSE GASSKKTSKK TGREETESRS SHKKHKKESH
     TPRSGGTPDS ASSTGGELEA GELIIDDSFH EMKKKKKSKK SKKKKDKHKD EKHRKHSKSK
     REHEGEERPT QIASPVLPSP PPPTATTPTS PPSVPPQALI THAEEQLDKK KKKEDPEKPK
     KKNMSAYQVF SKEYRGSIIA EHPGIDFGEL SKKLAEVWKQ LPEKDKLAWK QKAQYLQHKQ
     NKAEATTVKR KSSSSESAAR SKGSSSGLPS PNKKSPTSVV SFSTSPAKVP DTEPIDVAAH
     LQLLGESLSL IGHRLQETEG MVAVSGSLSV LLDSILCALG PLVCLTSHVP QLNACPKQIL
     SNTLDNIAYV MPGL