HMGX7_CHICK
ID HMGX7_CHICK Reviewed; 288 AA.
AC P50223;
DT 01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-1996, sequence version 1.
DT 03-AUG-2022, entry version 153.
DE RecName: Full=Homeobox protein GHOX-7;
DE AltName: Full=CHOX-7;
DE Short=Hox-7;
GN Name=GHOX-7;
OS Gallus gallus (Chicken).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC Phasianinae; Gallus.
OX NCBI_TaxID=9031;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=White leghorn; TISSUE=Limb bud;
RX PubMed=1346246; DOI=10.1016/s0006-291x(05)80120-2;
RA Nohno T., Noji S., Koyama E., Nishikawa K., Myokai F., Saito T.,
RA Taniguchi S.;
RT "Differential expression of two msh-related homeobox genes Chox-7 and Chox-
RT 8 during chick limb development.";
RL Biochem. Biophys. Res. Commun. 182:121-128(1992).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 130-288.
RC TISSUE=Limb bud;
RX PubMed=1350765; DOI=10.1111/j.1432-0436.1992.tb00772.x;
RA Coelho C.N.D., Sumoy L., Kosher R.A., Upholt W.B.;
RT "GHox-7: a chicken homeobox-containing gene expressed in a fashion
RT consistent with a role in patterning events during embryonic chick limb
RT development.";
RL Differentiation 49:85-92(1992).
RN [3]
RP TISSUE SPECIFICITY.
RX PubMed=1684333; DOI=10.1101/gad.5.12b.2363;
RA Robert B., Lyons G., Simandl B.K., Kuroiwa A., Buckingham M.;
RT "The apical ectodermal ridge regulates Hox-7 and Hox-8 gene expression in
RT developing chick limb buds.";
RL Genes Dev. 5:2363-2374(1991).
CC -!- FUNCTION: Probably plays a role in patterning events during embryonic
CC limb development. May also be involved in programmed cell death.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- DEVELOPMENTAL STAGE: Early limb development. First present in an
CC asymmetric arc extending from the anterior border of the limb bud to
CC the mesenchymal cells directly adjacent to the AER. Later abundantly
CC expressed in the proximal anterior periphery and in the mid-proximal
CC region of the posterior periphery. In older wing buds, detectable
CC throughout the necrotic mesenchyme between the developing digits.
CC -!- SIMILARITY: Belongs to the Msh homeobox family. {ECO:0000305}.
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DR EMBL; D10372; BAA01209.1; -; mRNA.
DR EMBL; X65791; CAA46671.1; -; mRNA.
DR PIR; JS0659; JS0659.
DR RefSeq; NP_990819.1; NM_205488.2.
DR AlphaFoldDB; P50223; -.
DR SMR; P50223; -.
DR STRING; 9031.ENSGALP00000024163; -.
DR PaxDb; P50223; -.
DR Ensembl; ENSGALT00000024209; ENSGALP00000024163; ENSGALG00000015013.
DR GeneID; 396484; -.
DR KEGG; gga:396484; -.
DR CTD; 4487; -.
DR VEuPathDB; HostDB:geneid_396484; -.
DR eggNOG; KOG0492; Eukaryota.
DR GeneTree; ENSGT00940000161623; -.
DR HOGENOM; CLU_072675_1_0_1; -.
DR InParanoid; P50223; -.
DR OMA; MQTPRFS; -.
DR OrthoDB; 1226077at2759; -.
DR PhylomeDB; P50223; -.
DR TreeFam; TF350699; -.
DR PRO; PR:P50223; -.
DR Proteomes; UP000000539; Chromosome 4.
DR Bgee; ENSGALG00000015013; Expressed in cerebellum and 1 other tissue.
DR GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0005667; C:transcription regulator complex; IEA:Ensembl.
DR GO; GO:0000987; F:cis-regulatory region sequence-specific DNA binding; IEA:Ensembl.
DR GO; GO:0001228; F:DNA-binding transcription activator activity, RNA polymerase II-specific; IEA:Ensembl.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0001227; F:DNA-binding transcription repressor activity, RNA polymerase II-specific; IEA:Ensembl.
DR GO; GO:0002039; F:p53 binding; IEA:Ensembl.
DR GO; GO:0000977; F:RNA polymerase II transcription regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0090427; P:activation of meiosis; IEA:Ensembl.
DR GO; GO:0009952; P:anterior/posterior pattern specification; IEA:Ensembl.
DR GO; GO:0061312; P:BMP signaling pathway involved in heart development; IEA:Ensembl.
DR GO; GO:0060349; P:bone morphogenesis; IEA:Ensembl.
DR GO; GO:0060536; P:cartilage morphogenesis; IEA:Ensembl.
DR GO; GO:0000902; P:cell morphogenesis; IEA:Ensembl.
DR GO; GO:0035115; P:embryonic forelimb morphogenesis; IEA:Ensembl.
DR GO; GO:0035116; P:embryonic hindlimb morphogenesis; IEA:Ensembl.
DR GO; GO:0048598; P:embryonic morphogenesis; IBA:GO_Central.
DR GO; GO:0035880; P:embryonic nail plate morphogenesis; IEA:Ensembl.
DR GO; GO:0003198; P:epithelial to mesenchymal transition involved in endocardial cushion formation; IEA:Ensembl.
DR GO; GO:0060325; P:face morphogenesis; IEA:Ensembl.
DR GO; GO:0030900; P:forebrain development; IEA:Ensembl.
DR GO; GO:0097152; P:mesenchymal cell apoptotic process; IEA:Ensembl.
DR GO; GO:0010463; P:mesenchymal cell proliferation; IEA:Ensembl.
DR GO; GO:0030901; P:midbrain development; IEA:Ensembl.
DR GO; GO:0042474; P:middle ear morphogenesis; IEA:Ensembl.
DR GO; GO:0007517; P:muscle organ development; IEA:Ensembl.
DR GO; GO:0043066; P:negative regulation of apoptotic process; IEA:Ensembl.
DR GO; GO:0030308; P:negative regulation of cell growth; IEA:Ensembl.
DR GO; GO:0008285; P:negative regulation of cell population proliferation; IEA:Ensembl.
DR GO; GO:0051154; P:negative regulation of striated muscle cell differentiation; IEA:Ensembl.
DR GO; GO:2000678; P:negative regulation of transcription regulatory region DNA binding; IEA:Ensembl.
DR GO; GO:0030513; P:positive regulation of BMP signaling pathway; IEA:Ensembl.
DR GO; GO:1902255; P:positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator; IEA:Ensembl.
DR GO; GO:2001055; P:positive regulation of mesenchymal cell apoptotic process; IEA:Ensembl.
DR GO; GO:0034504; P:protein localization to nucleus; IEA:Ensembl.
DR GO; GO:0050821; P:protein stabilization; IEA:Ensembl.
DR GO; GO:0042481; P:regulation of odontogenesis; IEA:Ensembl.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0060021; P:roof of mouth development; IEA:Ensembl.
DR GO; GO:0023019; P:signal transduction involved in regulation of gene expression; IEA:Ensembl.
DR GO; GO:0048863; P:stem cell differentiation; IEA:Ensembl.
DR GO; GO:0006366; P:transcription by RNA polymerase II; IEA:Ensembl.
DR CDD; cd00086; homeodomain; 1.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR017970; Homeobox_CS.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR020479; Homeobox_metazoa.
DR Pfam; PF00046; Homeodomain; 1.
DR PRINTS; PR00024; HOMEOBOX.
DR SMART; SM00389; HOX; 1.
DR SUPFAM; SSF46689; SSF46689; 1.
DR PROSITE; PS00027; HOMEOBOX_1; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
PE 2: Evidence at transcript level;
KW Developmental protein; DNA-binding; Homeobox; Nucleus; Reference proteome.
FT CHAIN 1..288
FT /note="Homeobox protein GHOX-7"
FT /id="PRO_0000049081"
FT DNA_BIND 161..220
FT /note="Homeobox"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT REGION 1..111
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 123..152
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 136..150
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VARIANT 247
FT /note="G -> S (in GHOX-7D)"
FT CONFLICT 130
FT /note="E -> G (in Ref. 2; CAA46671)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 288 AA; 30517 MW; 71BD89C67CCC256C CRC64;
MAPAADMTTA PTGVRSDEPP ASAFSKPGGG LPVAAAMGGE EESDKPKVSP SPLPFSVEAL
MADRRKPPGG RDGPEGSGPP LGSARANLGA LTTEAPTSPL PLGGHFPSVG ALGKLPEDAL
LKAESPEKPE RSPWMQSPRF SPPPPRRLSP PACTLRKHKT NRKPRTPFTT AQLLALERKF
RQKQYLSIAE RAEFSSSLSL TETQVKIWFQ NRRAKAKRLQ EAELEKLKMA AKPMLPPAAF
GISFPLGGPA VAGASLYGAS SPFQRAGLPV APVGLYTAHV GYSMYHLT
