HMH2_DROME
ID HMH2_DROME Reviewed; 418 AA.
AC P10035; Q1LYZ9; Q8MS25; Q9VMJ3;
DT 01-JUL-1989, integrated into UniProtKB/Swiss-Prot.
DT 24-MAY-2005, sequence version 2.
DT 03-AUG-2022, entry version 174.
DE RecName: Full=Homeobox protein H2.0;
GN Name=H2.0; ORFNames=CG11607;
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, AND TISSUE SPECIFICITY.
RX PubMed=2901348; DOI=10.1002/j.1460-2075.1988.tb03054.x;
RA Barad M., Jack T., Chadwick R., McGinnis W.;
RT "A novel, tissue-specific, Drosophila homeobox gene.";
RL EMBO J. 7:2151-2161(1988).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley;
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=Berkeley;
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Berkeley; TISSUE=Embryo;
RX PubMed=12537569; DOI=10.1186/gb-2002-3-12-research0080;
RA Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A.,
RA Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M.,
RA Celniker S.E.;
RT "A Drosophila full-length cDNA resource.";
RL Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Berkeley;
RA Stapleton M., Carlson J.W., Frise E., Kapadia B., Park S., Wan K.H., Yu C.,
RA Celniker S.E.;
RL Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases.
RN [6]
RP FUNCTION, AND TISSUE SPECIFICITY.
RX PubMed=1678322; DOI=10.1002/dvg.1020120305;
RA Barad M., Erlebacher A., McGinnis W.;
RT "Despite expression in embryonic visceral mesoderm, H2.0 is not essential
RT for Drosophila visceral muscle morphogenesis.";
RL Dev. Genet. 12:206-211(1991).
CC -!- FUNCTION: May play a role in pattern formation during embryonic and
CC imaginal development. Is not essential for visceral muscle
CC morphogenesis. {ECO:0000269|PubMed:1678322,
CC ECO:0000269|PubMed:2901348}.
CC -!- INTERACTION:
CC P10035; Q058Z8: Dmel\CG30324; NbExp=4; IntAct=EBI-149544, EBI-148486;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108}.
CC -!- TISSUE SPECIFICITY: Expressed in cells of the visceral musculature and
CC its anlagen. {ECO:0000269|PubMed:1678322, ECO:0000269|PubMed:2901348}.
CC -!- SIMILARITY: Belongs to the H2.0 homeobox family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=CAA68766.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; Y00843; CAA68766.1; ALT_INIT; mRNA.
DR EMBL; AE014134; AAF52323.2; -; Genomic_DNA.
DR EMBL; AY119136; AAM50996.1; -; mRNA.
DR EMBL; BT025227; ABF17918.1; -; mRNA.
DR PIR; S00994; WJFFH2.
DR RefSeq; NP_523488.2; NM_078764.3.
DR AlphaFoldDB; P10035; -.
DR SMR; P10035; -.
DR BioGRID; 60006; 33.
DR IntAct; P10035; 26.
DR STRING; 7227.FBpp0078858; -.
DR PaxDb; P10035; -.
DR DNASU; 33841; -.
DR EnsemblMetazoa; FBtr0079227; FBpp0078858; FBgn0001170.
DR GeneID; 33841; -.
DR KEGG; dme:Dmel_CG11607; -.
DR CTD; 33841; -.
DR FlyBase; FBgn0001170; H2.0.
DR VEuPathDB; VectorBase:FBgn0001170; -.
DR eggNOG; KOG0488; Eukaryota.
DR GeneTree; ENSGT00950000183093; -.
DR HOGENOM; CLU_710319_0_0_1; -.
DR InParanoid; P10035; -.
DR OMA; MDYKSVL; -.
DR OrthoDB; 858478at2759; -.
DR PhylomeDB; P10035; -.
DR SignaLink; P10035; -.
DR BioGRID-ORCS; 33841; 0 hits in 1 CRISPR screen.
DR GenomeRNAi; 33841; -.
DR PRO; PR:P10035; -.
DR Proteomes; UP000000803; Chromosome 2L.
DR Bgee; FBgn0001170; Expressed in visceral mesoderm and 9 other tissues.
DR Genevisible; P10035; DM.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR GO; GO:0043565; F:sequence-specific DNA binding; IBA:GO_Central.
DR CDD; cd00086; homeodomain; 1.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR017970; Homeobox_CS.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR020479; Homeobox_metazoa.
DR Pfam; PF00046; Homeodomain; 1.
DR PRINTS; PR00024; HOMEOBOX.
DR SMART; SM00389; HOX; 1.
DR SUPFAM; SSF46689; SSF46689; 1.
DR PROSITE; PS00027; HOMEOBOX_1; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
PE 1: Evidence at protein level;
KW Developmental protein; DNA-binding; Homeobox; Nucleus; Reference proteome.
FT CHAIN 1..418
FT /note="Homeobox protein H2.0"
FT /id="PRO_0000049064"
FT DNA_BIND 295..354
FT /note="Homeobox"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT REGION 190..223
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 259..296
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 354..418
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 192..214
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 263..296
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 360..401
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 402..418
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 224
FT /note="S -> T (in Ref. 1; CAA68766)"
FT /evidence="ECO:0000305"
FT CONFLICT 249
FT /note="T -> A (in Ref. 4; AAM50996)"
FT /evidence="ECO:0000305"
FT CONFLICT 267
FT /note="A -> AA (in Ref. 1; CAA68766)"
FT /evidence="ECO:0000305"
FT CONFLICT 385
FT /note="T -> A (in Ref. 1; CAA68766)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 418 AA; 45835 MW; DDEC3C347FFDFB4D CRC64;
MLLHESAASM EQSMPENLST HMYGECEVNP TLAKCPDPVN VDHELPTKES CASTTIVSTS
PTSATSTTKV KLSFSVDRLL GSEPEESHRQ SSSSPSTKSC CDGSILACCS FPHCFSQANA
ESRRFGHATL PPTFTPTSSH TYPFVGLDKL FPGPYMDYKS VLRPTPIRAA EHAAPTYPTL
ATNALLRFHQ HQKQQHQQHH HHQHHPKHLH QQHKPPPHNS TTASALLAPL HSLTSLQLTQ
QQQRFLGKTP QQLLDIAPTS PAAAAAATSQ NGAHGHGGGN GQGNASAGSN GKRKRSWSRA
VFSNLQRKGL EIQFQQQKYI TKPDRRKLAA RLNLTDAQVK VWFQNRRMKW RHTRENLKSG
QEKQPSAVPE SGGVFKTSTP SGDGTPQEAL DYSSDSCSSV DLSEQADEDD NIEINVVE
