ID   HMH2_GIRTI              Reviewed;         363 AA.
AC   Q00401;
DT   01-OCT-1993, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1993, sequence version 1.
DT   25-MAY-2022, entry version 86.
DE   RecName: Full=Homeobox protein DTH-2;
GN   Name=DTH-2;
OS   Girardia tigrina (Planarian) (Dugesia tigrina).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes;
OC   Rhabditophora; Seriata; Tricladida; Continenticola; Geoplanoidea;
OC   Dugesiidae; Girardia.
OX   NCBI_TaxID=6162;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=1714599; DOI=10.1073/pnas.88.16.7338;
RA   Salo E., Garcia-Fernandez J., Baguna J.;
RT   "Planarian homeobox genes: cloning, sequence analysis, and expression.";
RL   Proc. Natl. Acad. Sci. U.S.A. 88:7338-7342(1991).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=8104142; DOI=10.1242/dev.118.1.241;
RA   Garcia-Fernandez J., Baguna J., Salo E.;
RT   "Genomic organization and expression of the planarian homeobox genes Dth-1
RT   and Dth-2.";
RL   Development 118:241-253(1993).
CC   -!- FUNCTION: This protein might be involved in determination and/or
CC       differentiation of nerve cells in the continuous replacement of neurons
CC       in the cephalic region.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC   -!- TISSUE SPECIFICITY: Intestine and unidentified peripheral parenchymal
CC       cells. Slightly higher levels in the cephalic region compared to other
CC       body regions.
CC   -!- SIMILARITY: Belongs to the NK-2 homeobox family. {ECO:0000305}.
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DR   EMBL; X56500; CAA39855.1; -; mRNA.
DR   EMBL; X69202; CAA49140.1; -; Genomic_DNA.
DR   PIR; S33702; S33702.
DR   AlphaFoldDB; Q00401; -.
DR   SMR; Q00401; -.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR   CDD; cd00086; homeodomain; 1.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR017970; Homeobox_CS.
DR   InterPro; IPR001356; Homeobox_dom.
DR   InterPro; IPR020479; Homeobox_metazoa.
DR   Pfam; PF00046; Homeodomain; 1.
DR   PRINTS; PR00024; HOMEOBOX.
DR   SMART; SM00389; HOX; 1.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   PROSITE; PS00027; HOMEOBOX_1; 1.
DR   PROSITE; PS50071; HOMEOBOX_2; 1.
PE   2: Evidence at transcript level;
KW   Developmental protein; DNA-binding; Homeobox; Nucleus.
FT   CHAIN           1..363
FT                   /note="Homeobox protein DTH-2"
FT                   /id="PRO_0000049065"
FT   DNA_BIND        133..192
FT                   /note="Homeobox"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT   REGION          189..246
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        189..220
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   363 AA;  40338 MW;  4FBDED68E60CE2C1 CRC64;
     MSGIPGLAGM SSMSPYSAYA ALTQHTGVSS GSSPFGSQYC SSVNDFNPYS DPRGSNTWYG
     MAASANASND PRMTMSRLMG SAAAAASSSM SAYSGIPTNF HQGMHSAMGM ASLGAATYDH
     QKAAMQFNNM SQRRKRRILF SQAQIYELER RFKQQKYLSA PEREHLANLI NLTPTQVKIW
     FQNHRYKCKR SQKDKEKEQQ KEKSYHLKKN IVDDKERSPN KQICNASSSD RSTPEEPVAK
     AKESGLDFSN HKIDNLNLKM EADLEPKSSL YSIIPPYLTN SYAQQTQSEA QTSPIINNVL
     GSNLFPERKS TPTMGPLTSY SFGQSMDSIS SFYSPDFSLY NCAHPYMAAS SSYFMNAASR
     PWN