ID   HMIN_BOMMO              Reviewed;         476 AA.
AC   P27610;
DT   01-AUG-1992, integrated into UniProtKB/Swiss-Prot.
DT   01-AUG-1992, sequence version 1.
DT   03-AUG-2022, entry version 118.
DE   RecName: Full=Homeobox protein invected;
GN   Name=INV;
OS   Bombyx mori (Silk moth).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Lepidoptera; Glossata; Ditrysia; Bombycoidea;
OC   Bombycidae; Bombycinae; Bombyx.
OX   NCBI_TaxID=7091;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=Kinshu X Showa; TISSUE=Middle silk gland;
RX   PubMed=1346065; DOI=10.1073/pnas.89.1.167;
RA   Hui C.-C., Matsuno K., Ueno K., Suzuki Y.;
RT   "Molecular characterization and silk gland expression of Bombyx engrailed
RT   and invected genes.";
RL   Proc. Natl. Acad. Sci. U.S.A. 89:167-171(1992).
CC   -!- FUNCTION: This protein might be involved in the compartmentalization of
CC       the silk gland.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108}.
CC   -!- TISSUE SPECIFICITY: Expressed in the middle silk gland but not in the
CC       posterior silk gland during the fourth molt/fifth intermolt period.
CC   -!- SIMILARITY: Belongs to the engrailed homeobox family. {ECO:0000305}.
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DR   EMBL; M64336; AAA67313.1; -; mRNA.
DR   PIR; B41792; B41792.
DR   RefSeq; NP_001037454.1; NM_001043989.1.
DR   AlphaFoldDB; P27610; -.
DR   SMR; P27610; -.
DR   STRING; 7091.BGIBMGA009643-TA; -.
DR   GeneID; 693024; -.
DR   KEGG; bmor:693024; -.
DR   CTD; 36239; -.
DR   eggNOG; KOG0493; Eukaryota.
DR   HOGENOM; CLU_040714_0_0_1; -.
DR   InParanoid; P27610; -.
DR   OrthoDB; 1575614at2759; -.
DR   Proteomes; UP000005204; Unassembled WGS sequence.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR   GO; GO:0030154; P:cell differentiation; IEA:UniProt.
DR   GO; GO:0007399; P:nervous system development; IEA:UniProt.
DR   CDD; cd00086; homeodomain; 1.
DR   InterPro; IPR019549; Homeobox-engrailed_C-terminal.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR017970; Homeobox_CS.
DR   InterPro; IPR001356; Homeobox_dom.
DR   InterPro; IPR000747; Homeobox_engrailed.
DR   InterPro; IPR020479; Homeobox_metazoa.
DR   InterPro; IPR019737; Homoebox-engrailed_CS.
DR   InterPro; IPR000047; HTH_motif.
DR   Pfam; PF10525; Engrail_1_C_sig; 1.
DR   Pfam; PF00046; Homeodomain; 1.
DR   PRINTS; PR00026; ENGRAILED.
DR   PRINTS; PR00024; HOMEOBOX.
DR   PRINTS; PR00031; HTHREPRESSR.
DR   SMART; SM00389; HOX; 1.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   PROSITE; PS00033; ENGRAILED; 1.
DR   PROSITE; PS00027; HOMEOBOX_1; 1.
DR   PROSITE; PS50071; HOMEOBOX_2; 1.
PE   2: Evidence at transcript level;
KW   Developmental protein; DNA-binding; Homeobox; Nucleus; Reference proteome.
FT   CHAIN           1..476
FT                   /note="Homeobox protein invected"
FT                   /id="PRO_0000196080"
FT   DNA_BIND        372..431
FT                   /note="Homeobox"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT   REGION          1..43
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          273..331
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          347..381
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        295..312
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        314..331
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        351..373
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   476 AA;  53585 MW;  CCD219F4667EEC02 CRC64;
     MAAVSAHMQD IKIQDQSDDD PYSPNTRDTT SPECHDDEKS EDISIRSSSF SIHNVLRRSG
     TTAALTMSFR RKSSWRIPNF DDRNTESVSP VVEVNEREIS VDDGNSCCSD DTVLSVGNEA
     PVSNYEEKAS QNTHQELTSF KHIQTHLSAI SQLSQNMNVA QPLLLRPSPI NPNPIMFLNQ
     PLLFQSPILS QDLKGMPNRQ TANVISPTFG LNFGMRLKAN HETRTRSDEN RYSKPEESRD
     YINQNCLKFS IDNILKADFG RRITDPLHKR KVKTRYEAKP APAKDTAAFA PKLDEARVPD
     IKTPDKAGAI DLSKDDSGSN SGSTSGATSG DSPMVWPAWV YCTRYSDRPS SGRSPRTRRP
     KKPPGDTASN DEKRPRTAFS GPQLARLKHE FAENRYLTER RRQSLAAELG LAEAQIKIWF
     QNKRAKIKKA SGQRNPLALQ LMAQGLYNHS TVPLTKEEEE LEMKARERER ELKNRC