ID   HMMR_RHILV              Reviewed;         129 AA.
AC   Q9X5V4;
DT   30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1999, sequence version 1.
DT   25-MAY-2022, entry version 79.
DE   RecName: Full=HTH-type transcriptional regulator HmrR;
DE   AltName: Full=Copper efflux regulator;
DE   AltName: Full=Copper export regulator;
GN   Name=hmrR;
OS   Rhizobium leguminosarum bv. viciae.
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Hyphomicrobiales;
OC   Rhizobiaceae; Rhizobium/Agrobacterium group; Rhizobium.
OX   NCBI_TaxID=387;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND FUNCTION.
RC   STRAIN=WSM710;
RX   PubMed=11936079; DOI=10.1046/j.1365-2958.2002.02791.x;
RA   Reeve W.G., Tiwari R.P., Kale N.B., Dilworth M.J., Glenn A.R.;
RT   "ActP controls copper homeostasis in Rhizobium leguminosarum bv. viciae and
RT   Sinorhizobium meliloti preventing low pH-induced copper toxicity.";
RL   Mol. Microbiol. 43:981-991(2002).
CC   -!- FUNCTION: Regulates the transcription of actP. It detects cytoplasmic
CC       copper stress and activates transcription in response to increasing
CC       copper concentrations. In the absence of copper, it negatively
CC       regulates the transcription of actP. {ECO:0000269|PubMed:11936079}.
CC   -!- SUBUNIT: Homodimer. {ECO:0000305}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}.
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DR   EMBL; AF127795; AAD26861.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q9X5V4; -.
DR   SMR; Q9X5V4; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005507; F:copper ion binding; IEA:InterPro.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR   GO; GO:0045893; P:positive regulation of transcription, DNA-templated; IEA:InterPro.
DR   CDD; cd01108; HTH_CueR; 1.
DR   InterPro; IPR011789; CueR.
DR   InterPro; IPR009061; DNA-bd_dom_put_sf.
DR   InterPro; IPR000551; MerR-type_HTH_dom.
DR   InterPro; IPR015358; Tscrpt_reg_MerR_DNA-bd.
DR   Pfam; PF00376; MerR; 1.
DR   Pfam; PF09278; MerR-DNA-bind; 1.
DR   PRINTS; PR00040; HTHMERR.
DR   SMART; SM00422; HTH_MERR; 1.
DR   SUPFAM; SSF46955; SSF46955; 1.
DR   TIGRFAMs; TIGR02044; CueR; 1.
DR   PROSITE; PS50937; HTH_MERR_2; 1.
PE   4: Predicted;
KW   Activator; Copper; Cytoplasm; DNA-binding; Repressor; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..129
FT                   /note="HTH-type transcriptional regulator HmrR"
FT                   /id="PRO_0000098123"
FT   DOMAIN          1..68
FT                   /note="HTH merR-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00254"
FT   DNA_BIND        4..23
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00254"
SQ   SEQUENCE   129 AA;  14743 MW;  1F2553B327BE7788 CRC64;
     MNIGEASERS GLPSKTIRYY EDIGLIRPER GGNGYRDYAA TDVHKLRFLQ RSRGLGFSVE
     ECRQLLALYE DKDRASADVR DIAQTKLTEI DRKIRELTEL RRTLEHLVHA CHGNDRPDCP
     ILEELSDGA