ID   HMN11_HUMAN             Reviewed;          24 AA.
AC   S4R3Y5;
DT   26-NOV-2014, integrated into UniProtKB/Swiss-Prot.
DT   18-SEP-2013, sequence version 1.
DT   03-AUG-2022, entry version 41.
DE   RecName: Full=Humanin-like 11 {ECO:0000305};
DE            Short=HN11 {ECO:0000303|PubMed:19477263};
DE   AltName: Full=MT-RNR2-like protein 11 {ECO:0000312|HGNC:HGNC:37168};
GN   Name=MTRNR2L11 {ECO:0000312|HGNC:HGNC:37168};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16710414; DOI=10.1038/nature04727;
RA   Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A.,
RA   Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C.,
RA   Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.,
RA   Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C.,
RA   Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W.,
RA   Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J.,
RA   Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J.,
RA   Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y.,
RA   Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J.,
RA   Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H.,
RA   Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L.,
RA   Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J.,
RA   Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S.,
RA   Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K.,
RA   Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R.,
RA   Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M.,
RA   Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S.,
RA   Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J.,
RA   Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W.,
RA   McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N.,
RA   Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V.,
RA   Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J.,
RA   Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E.,
RA   Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S.,
RA   Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M.,
RA   White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H.,
RA   Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E.,
RA   Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G.,
RA   Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.;
RT   "The DNA sequence and biological annotation of human chromosome 1.";
RL   Nature 441:315-321(2006).
RN   [2]
RP   IDENTIFICATION.
RX   PubMed=19477263; DOI=10.1016/j.ygeno.2009.05.006;
RA   Bodzioch M., Lapicka-Bodzioch K., Zapala B., Kamysz W., Kiec-Wilk B.,
RA   Dembinska-Kiec A.;
RT   "Evidence for potential functionality of nuclearly-encoded humanin
RT   isoforms.";
RL   Genomics 94:247-256(2009).
CC   -!- FUNCTION: Plays a role as a neuroprotective and antiapoptotic factor.
CC       {ECO:0000250|UniProtKB:Q8IVG9}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:Q8IVG9}.
CC       Cytoplasm {ECO:0000250|UniProtKB:Q8IVG9}.
CC   -!- SIMILARITY: Belongs to the humanin family. {ECO:0000305}.
CC   -!- CAUTION: The humanin peptide has been shown to be biologically active
CC       but is the product of a mitochondrial gene, MT-RNR2. The mechanisms
CC       allowing the production and the secretion of humanin from the
CC       mitochondrial gene remaining unclear, the possibility exist that the
CC       physiologically active humanin peptide is encoded by one of the related
CC       genes present in the nuclear genome including the one described here
CC       (PubMed:19477263). {ECO:0000305|PubMed:19477263}.
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DR   EMBL; AL590396; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   AlphaFoldDB; S4R3Y5; -.
DR   STRING; 9606.ENSP00000474861; -.
DR   BioMuta; MTRNR2L11; -.
DR   PRIDE; S4R3Y5; -.
DR   Ensembl; ENST00000604646.1; ENSP00000474861.1; ENSG00000270188.1.
DR   UCSC; uc057qqv.1; human.
DR   GeneCards; MTRNR2L11; -.
DR   HGNC; HGNC:37168; MTRNR2L11.
DR   HPA; ENSG00000270188; Tissue enriched (brain).
DR   neXtProt; NX_S4R3Y5; -.
DR   OpenTargets; ENSG00000270188; -.
DR   VEuPathDB; HostDB:ENSG00000270188; -.
DR   GeneTree; ENSGT01030000235855; -.
DR   HOGENOM; CLU_221584_0_0_1; -.
DR   PhylomeDB; S4R3Y5; -.
DR   PathwayCommons; S4R3Y5; -.
DR   ChiTaRS; MTRNR2L11; human.
DR   Pharos; S4R3Y5; Tdark.
DR   PRO; PR:S4R3Y5; -.
DR   Proteomes; UP000005640; Chromosome 1.
DR   Bgee; ENSG00000270188; Expressed in apex of heart and 57 other tissues.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0048019; F:receptor antagonist activity; IBA:GO_Central.
DR   GO; GO:1900118; P:negative regulation of execution phase of apoptosis; IBA:GO_Central.
DR   CDD; cd20245; humanin; 1.
DR   InterPro; IPR028139; Humanin.
DR   PANTHER; PTHR33895; PTHR33895; 1.
DR   Pfam; PF15040; Humanin; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Reference proteome; Secreted.
FT   CHAIN           1..24
FT                   /note="Humanin-like 11"
FT                   /id="PRO_0000431294"
SQ   SEQUENCE   24 AA;  2737 MW;  17AED762D9E404B1 CRC64;
     MATRGFSCLL LVISEIDLSV KRWV