ID   HMN12_HUMAN             Reviewed;          24 AA.
AC   P0DMP1;
DT   01-OCT-2014, integrated into UniProtKB/Swiss-Prot.
DT   29-SEP-2021, sequence version 2.
DT   03-AUG-2022, entry version 34.
DE   RecName: Full=Humanin-like 12 {ECO:0000305};
DE            Short=HN12 {ECO:0000303|PubMed:19477263};
DE   AltName: Full=MT-RNR2-like protein 12 {ECO:0000312|HGNC:HGNC:37169};
GN   Name=MTRNR2L12 {ECO:0000312|HGNC:HGNC:37169};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16641997; DOI=10.1038/nature04728;
RA   Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J.,
RA   Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P.,
RA   Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A.,
RA   Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L.,
RA   Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G.,
RA   Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W.,
RA   Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M.,
RA   Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P.,
RA   Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H.,
RA   Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J.,
RA   Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W.,
RA   Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B.,
RA   Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O.,
RA   Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B.,
RA   Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H.,
RA   Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J.,
RA   Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X.,
RA   Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R.,
RA   Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.;
RT   "The DNA sequence, annotation and analysis of human chromosome 3.";
RL   Nature 440:1194-1198(2006).
RN   [2]
RP   IDENTIFICATION.
RX   PubMed=19477263; DOI=10.1016/j.ygeno.2009.05.006;
RA   Bodzioch M., Lapicka-Bodzioch K., Zapala B., Kamysz W., Kiec-Wilk B.,
RA   Dembinska-Kiec A.;
RT   "Evidence for potential functionality of nuclearly-encoded humanin
RT   isoforms.";
RL   Genomics 94:247-256(2009).
CC   -!- FUNCTION: Plays a role as a neuroprotective and antiapoptotic factor.
CC       {ECO:0000250|UniProtKB:Q8IVG9}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:Q8IVG9}.
CC       Cytoplasm {ECO:0000250|UniProtKB:Q8IVG9}.
CC   -!- SIMILARITY: Belongs to the humanin family. {ECO:0000305}.
CC   -!- CAUTION: The humanin peptide has been shown to be biologically active
CC       but is the product of a mitochondrial gene, MT-RNR2. The mechanisms
CC       allowing the production and the secretion of humanin from the
CC       mitochondrial gene remaining unclear, the possibility exist that the
CC       physiologically active humanin peptide is encoded by one of the related
CC       genes present in the nuclear genome including the one described here
CC       (PubMed:19477263). {ECO:0000305|PubMed:19477263}.
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DR   EMBL; AC117444; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; NP_001177631.1; NM_001190702.1.
DR   AlphaFoldDB; P0DMP1; -.
DR   BioMuta; MTRNR2L12; -.
DR   PRIDE; P0DMP1; -.
DR   Ensembl; ENST00000600213.3; ENSP00000468991.1; ENSG00000269028.3.
DR   GeneID; 100463486; -.
DR   UCSC; uc062lty.1; human.
DR   CTD; 100463486; -.
DR   GeneCards; MTRNR2L12; -.
DR   HGNC; HGNC:37169; MTRNR2L12.
DR   HPA; ENSG00000269028; Tissue enhanced (brain, choroid plexus).
DR   neXtProt; NX_P0DMP1; -.
DR   OpenTargets; ENSG00000255823; -.
DR   OpenTargets; ENSG00000269028; -.
DR   VEuPathDB; HostDB:ENSG00000269028; -.
DR   GeneTree; ENSGT01020000230764; -.
DR   HOGENOM; CLU_221584_0_0_1; -.
DR   ChiTaRS; MTRNR2L12; human.
DR   Pharos; P0DMP1; Tdark.
DR   PRO; PR:P0DMP1; -.
DR   Proteomes; UP000005640; Chromosome 3.
DR   Bgee; ENSG00000269028; Expressed in sural nerve and 98 other tissues.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0048019; F:receptor antagonist activity; IBA:GO_Central.
DR   GO; GO:1900118; P:negative regulation of execution phase of apoptosis; IBA:GO_Central.
DR   CDD; cd20245; humanin; 1.
DR   InterPro; IPR028139; Humanin.
DR   PANTHER; PTHR33895; PTHR33895; 1.
DR   Pfam; PF15040; Humanin; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Reference proteome; Secreted.
FT   CHAIN           1..24
FT                   /note="Humanin-like 12"
FT                   /id="PRO_0000430277"
SQ   SEQUENCE   24 AA;  2661 MW;  08B9A778F4B0B971 CRC64;
     MAPRGFSCLL LSTSEIDLPV KRRA