HMN1_HUMAN
ID HMN1_HUMAN Reviewed; 24 AA.
AC P0CJ68;
DT 08-FEB-2011, integrated into UniProtKB/Swiss-Prot.
DT 08-FEB-2011, sequence version 1.
DT 03-AUG-2022, entry version 67.
DE RecName: Full=Humanin-like 1 {ECO:0000305};
DE Short=HN1 {ECO:0000303|PubMed:19477263};
DE AltName: Full=MT-RNR2-like protein 1 {ECO:0000312|HGNC:HGNC:37155};
GN Name=MTRNR2L1 {ECO:0000312|HGNC:HGNC:37155};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RA Li W.B., Gruber C., Jessee J., Polayes D.;
RT "Full-length cDNA libraries and normalization.";
RL Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16625196; DOI=10.1038/nature04689;
RA Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R.,
RA Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A.,
RA Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J.,
RA Chang J.L., Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J.,
RA DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S.,
RA Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E.,
RA Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K.,
RA LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J.,
RA Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A.,
RA Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K.,
RA Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D.,
RA Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A.,
RA Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.;
RT "DNA sequence of human chromosome 17 and analysis of rearrangement in the
RT human lineage.";
RL Nature 440:1045-1049(2006).
RN [3]
RP TISSUE SPECIFICITY, AND INDUCTION.
RX PubMed=19477263; DOI=10.1016/j.ygeno.2009.05.006;
RA Bodzioch M., Lapicka-Bodzioch K., Zapala B., Kamysz W., Kiec-Wilk B.,
RA Dembinska-Kiec A.;
RT "Evidence for potential functionality of nuclearly-encoded humanin
RT isoforms.";
RL Genomics 94:247-256(2009).
CC -!- FUNCTION: Plays a role as a neuroprotective and antiapoptotic factor.
CC {ECO:0000250|UniProtKB:Q8IVG9}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:Q8IVG9}.
CC Cytoplasm {ECO:0000250|UniProtKB:Q8IVG9}.
CC -!- TISSUE SPECIFICITY: Highly expressed in the kidney, heart muscle and
CC testis. {ECO:0000269|PubMed:19477263}.
CC -!- INDUCTION: Down-regulated 6 hours following staurosporine (STS)
CC treatment and up-regulated 24 hours following STS treatment. Down-
CC regulated 6 hours following beta-carotene treatment.
CC {ECO:0000269|PubMed:19477263}.
CC -!- SIMILARITY: Belongs to the humanin family. {ECO:0000305}.
CC -!- CAUTION: The humanin peptide has been shown to be biologically active
CC but is the product of a mitochondrial gene, MT-RNR2. The mechanisms
CC allowing the production and the secretion of humanin from the
CC mitochondrial gene remaining unclear, the possibility exist that the
CC physiologically active humanin peptide is encoded by one of the related
CC genes present in the nuclear genome including the one described here
CC (PubMed:19477263). {ECO:0000305|PubMed:19477263}.
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DR EMBL; CR612552; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; AC131055; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; NP_001177381.1; NM_001190452.1.
DR AlphaFoldDB; P0CJ68; -.
DR BioGRID; 1148170; 9.
DR STRING; 9606.ENSP00000439228; -.
DR BioMuta; MTRNR2L1; -.
DR PaxDb; P0CJ68; -.
DR PRIDE; P0CJ68; -.
DR Antibodypedia; 55175; 34 antibodies from 13 providers.
DR DNASU; 100462977; -.
DR Ensembl; ENST00000540040.3; ENSP00000439228.1; ENSG00000256618.3.
DR GeneID; 100462977; -.
DR UCSC; uc002gzb.3; human.
DR CTD; 100462977; -.
DR GeneCards; MTRNR2L1; -.
DR HGNC; HGNC:37155; MTRNR2L1.
DR HPA; ENSG00000256618; Tissue enhanced (brain, choroid plexus).
DR MIM; 616985; gene.
DR neXtProt; NX_P0CJ68; -.
DR OpenTargets; ENSG00000256618; -.
DR VEuPathDB; HostDB:ENSG00000256618; -.
DR GeneTree; ENSGT01020000230765; -.
DR HOGENOM; CLU_221584_0_0_1; -.
DR PhylomeDB; P0CJ68; -.
DR PathwayCommons; P0CJ68; -.
DR SignaLink; P0CJ68; -.
DR BioGRID-ORCS; 100462977; 171 hits in 609 CRISPR screens.
DR ChiTaRS; MTRNR2L1; human.
DR GenomeRNAi; 100462977; -.
DR Pharos; P0CJ68; Tdark.
DR PRO; PR:P0CJ68; -.
DR Proteomes; UP000005640; Chromosome 17.
DR Bgee; ENSG00000256618; Expressed in sural nerve and 91 other tissues.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0048019; F:receptor antagonist activity; IBA:GO_Central.
DR GO; GO:1900118; P:negative regulation of execution phase of apoptosis; IBA:GO_Central.
DR CDD; cd20245; humanin; 1.
DR InterPro; IPR028139; Humanin.
DR PANTHER; PTHR33895; PTHR33895; 1.
DR Pfam; PF15040; Humanin; 1.
PE 2: Evidence at transcript level;
KW Cytoplasm; Reference proteome; Secreted.
FT CHAIN 1..24
FT /note="Humanin-like 1"
FT /id="PRO_0000404550"
SQ SEQUENCE 24 AA; 2691 MW; 14C9A778F4B0B971 CRC64;
MAPRGFSCLL LSTSEIDLPV KRRT
