ID   HMN2_HUMAN              Reviewed;          28 AA.
AC   P0CJ69;
DT   08-FEB-2011, integrated into UniProtKB/Swiss-Prot.
DT   08-FEB-2011, sequence version 1.
DT   03-AUG-2022, entry version 47.
DE   RecName: Full=Humanin-like 2 {ECO:0000305};
DE            Short=HN2 {ECO:0000303|PubMed:19477263};
DE   AltName: Full=MT-RNR2-like protein 2 {ECO:0000312|HGNC:HGNC:37156};
GN   Name=MTRNR2L2 {ECO:0000312|HGNC:HGNC:37156};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15372022; DOI=10.1038/nature02919;
RA   Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S.,
RA   Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M.,
RA   She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S.,
RA   Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M.,
RA   Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T., Gomez M.,
RA   Gonzales E., Goodstein D., Grigoriev I., Groza M., Hammon N., Hawkins T.,
RA   Haydu L., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A.,
RA   Lopez F., Lou Y., Martinez D., Medina C., Morgan J., Nandkeshwar R.,
RA   Noonan J.P., Pitluck S., Pollard M., Predki P., Priest J., Ramirez L.,
RA   Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., Thayer N.,
RA   Tice H., Tsai M., Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J.,
RA   Dickson M., Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A.,
RA   Rokhsar D.S., Richardson P., Lucas S.M., Myers R.M., Rubin E.M.;
RT   "The DNA sequence and comparative analysis of human chromosome 5.";
RL   Nature 431:268-274(2004).
RN   [2]
RP   TISSUE SPECIFICITY, AND INDUCTION.
RX   PubMed=19477263; DOI=10.1016/j.ygeno.2009.05.006;
RA   Bodzioch M., Lapicka-Bodzioch K., Zapala B., Kamysz W., Kiec-Wilk B.,
RA   Dembinska-Kiec A.;
RT   "Evidence for potential functionality of nuclearly-encoded humanin
RT   isoforms.";
RL   Genomics 94:247-256(2009).
CC   -!- FUNCTION: Plays a role as a neuroprotective and antiapoptotic factor.
CC       {ECO:0000250|UniProtKB:Q8IVG9}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:Q8IVG9}.
CC       Cytoplasm {ECO:0000250|UniProtKB:Q8IVG9}.
CC   -!- TISSUE SPECIFICITY: Highly expressed in testis. Also expressed in
CC       kidney, heart, skeletal muscles and brain.
CC       {ECO:0000269|PubMed:19477263}.
CC   -!- INDUCTION: Down-regulated 6 hours following staurosporine (STS)
CC       treatment and up-regulated 24 hours following STS treatment. Up-
CC       regulated 6 hours following beta-carotene treatment, returning to its
CC       basal level 24 hours following beta-carotene treatment.
CC       {ECO:0000269|PubMed:19477263}.
CC   -!- SIMILARITY: Belongs to the humanin family. {ECO:0000305}.
CC   -!- CAUTION: The humanin peptide has been shown to be biologically active
CC       but is the product of a mitochondrial gene, MT-RNR2. The mechanisms
CC       allowing the production and the secretion of humanin from the
CC       mitochondrial gene remaining unclear, the possibility exist that the
CC       physiologically active humanin peptide is encoded by one of the related
CC       genes present in the nuclear genome including the one described here
CC       (PubMed:19477263). {ECO:0000305|PubMed:19477263}.
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DR   EMBL; AC008434; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; NP_001177399.1; NM_001190470.1.
DR   AlphaFoldDB; P0CJ69; -.
DR   BioMuta; HGNC:37156; -.
DR   PRIDE; P0CJ69; -.
DR   DNASU; 100462981; -.
DR   GeneID; 100462981; -.
DR   CTD; 100462981; -.
DR   GeneCards; MTRNR2L2; -.
DR   HGNC; HGNC:37156; MTRNR2L2.
DR   neXtProt; NX_P0CJ69; -.
DR   PhylomeDB; P0CJ69; -.
DR   PathwayCommons; P0CJ69; -.
DR   BioGRID-ORCS; 100462981; 15 hits in 565 CRISPR screens.
DR   Pharos; P0CJ69; Tdark.
DR   PRO; PR:P0CJ69; -.
DR   Proteomes; UP000005640; Unplaced.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0048019; F:receptor antagonist activity; IBA:GO_Central.
DR   GO; GO:1900118; P:negative regulation of execution phase of apoptosis; IBA:GO_Central.
DR   CDD; cd20245; humanin; 1.
DR   InterPro; IPR028139; Humanin.
DR   PANTHER; PTHR33895; PTHR33895; 1.
DR   Pfam; PF15040; Humanin; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Reference proteome; Secreted.
FT   CHAIN           1..28
FT                   /note="Humanin-like 2"
FT                   /id="PRO_0000404551"
SQ   SEQUENCE   28 AA;  3081 MW;  F6E72CD5625A8778 CRC64;
     MAPRGFSCLL LSTSEIDLPV KRLLSSVF