HMN3_HUMAN
ID HMN3_HUMAN Reviewed; 24 AA.
AC P0CJ70;
DT 08-FEB-2011, integrated into UniProtKB/Swiss-Prot.
DT 08-FEB-2011, sequence version 1.
DT 03-AUG-2022, entry version 61.
DE RecName: Full=Humanin-like 3 {ECO:0000305};
DE Short=HN3 {ECO:0000303|PubMed:19477263};
DE AltName: Full=MT-RNR2-like protein 3 {ECO:0000312|HGNC:HGNC:37157};
GN Name=MTRNR2L3 {ECO:0000312|HGNC:HGNC:37157};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=11780052; DOI=10.1038/414865a;
RA Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R.,
RA Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L.,
RA Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P.,
RA Bird C.P., Blakey S.E., Bridgeman A.M., Brown A.J., Buck D., Burrill W.D.,
RA Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G.,
RA Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E.,
RA Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D.,
RA Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P.,
RA Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E.,
RA Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J.,
RA Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D.,
RA Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S.,
RA Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D.,
RA Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A.,
RA Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T.,
RA Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I.,
RA Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M.,
RA Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D.,
RA Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M.,
RA Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A.,
RA Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L.,
RA Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L.,
RA Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.;
RT "The DNA sequence and comparative analysis of human chromosome 20.";
RL Nature 414:865-871(2001).
RN [2]
RP TISSUE SPECIFICITY, AND INDUCTION.
RX PubMed=19477263; DOI=10.1016/j.ygeno.2009.05.006;
RA Bodzioch M., Lapicka-Bodzioch K., Zapala B., Kamysz W., Kiec-Wilk B.,
RA Dembinska-Kiec A.;
RT "Evidence for potential functionality of nuclearly-encoded humanin
RT isoforms.";
RL Genomics 94:247-256(2009).
CC -!- FUNCTION: Plays a role as a neuroprotective and antiapoptotic factor.
CC {ECO:0000250|UniProtKB:Q8IVG9}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:Q8IVG9}.
CC Cytoplasm {ECO:0000250|UniProtKB:Q8IVG9}.
CC -!- TISSUE SPECIFICITY: Highly expressed in testis. Also expressed in
CC kidney, heart, skeletal muscles and brain.
CC {ECO:0000269|PubMed:19477263}.
CC -!- INDUCTION: Down-regulated 6 hours following staurosporine (STS)
CC treatment and up-regulated 24 hours following STS treatment. Down-
CC regulated 6 hours following beta-carotene treatment, while it is up-
CC regulated 24 hours following beta-carotene treatment.
CC {ECO:0000269|PubMed:19477263}.
CC -!- SIMILARITY: Belongs to the humanin family. {ECO:0000305}.
CC -!- CAUTION: The humanin peptide has been shown to be biologically active
CC but is the product of a mitochondrial gene, MT-RNR2. The mechanisms
CC allowing the production and the secretion of humanin from the
CC mitochondrial gene remaining unclear, the possibility exist that the
CC physiologically active humanin peptide is encoded by one of the related
CC genes present in the nuclear genome including the one described here
CC (PubMed:19477263). {ECO:0000305|PubMed:19477263}.
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DR EMBL; AL109955; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL135939; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; NP_001177401.1; NM_001190472.1.
DR AlphaFoldDB; P0CJ70; -.
DR STRING; 9606.ENSP00000443339; -.
DR iPTMnet; P0CJ70; -.
DR PhosphoSitePlus; P0CJ70; -.
DR BioMuta; MTRNR2L3; -.
DR PaxDb; P0CJ70; -.
DR PRIDE; P0CJ70; -.
DR DNASU; 100462983; -.
DR Ensembl; ENST00000543500.3; ENSP00000443339.1; ENSG00000256222.3.
DR GeneID; 100462983; -.
DR UCSC; uc021wfd.2; human.
DR CTD; 100462983; -.
DR GeneCards; MTRNR2L3; -.
DR HGNC; HGNC:37157; MTRNR2L3.
DR HPA; ENSG00000256222; Group enriched (brain, skeletal muscle).
DR neXtProt; NX_P0CJ70; -.
DR OpenTargets; ENSG00000256222; -.
DR VEuPathDB; HostDB:ENSG00000256222; -.
DR GeneTree; ENSGT00940000170396; -.
DR HOGENOM; CLU_221584_0_0_1; -.
DR InParanoid; P0CJ70; -.
DR PhylomeDB; P0CJ70; -.
DR PathwayCommons; P0CJ70; -.
DR BioGRID-ORCS; 100462983; 47 hits in 615 CRISPR screens.
DR ChiTaRS; MTRNR2L3; human.
DR Pharos; P0CJ70; Tdark.
DR PRO; PR:P0CJ70; -.
DR Proteomes; UP000005640; Chromosome 20.
DR Bgee; ENSG00000256222; Expressed in hindlimb stylopod muscle and 66 other tissues.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0048019; F:receptor antagonist activity; IBA:GO_Central.
DR GO; GO:1900118; P:negative regulation of execution phase of apoptosis; IBA:GO_Central.
DR CDD; cd20245; humanin; 1.
DR InterPro; IPR028139; Humanin.
DR PANTHER; PTHR33895; PTHR33895; 1.
DR Pfam; PF15040; Humanin; 1.
PE 2: Evidence at transcript level;
KW Cytoplasm; Reference proteome; Secreted.
FT CHAIN 1..24
FT /note="Humanin-like 3"
FT /id="PRO_0000404552"
SQ SEQUENCE 24 AA; 2796 MW; 0539A763F50504B1 CRC64;
MATRRFSCLL LSTSEIDLSV KRRI
