HMN4_HUMAN
ID HMN4_HUMAN Reviewed; 28 AA.
AC P0CJ71;
DT 08-FEB-2011, integrated into UniProtKB/Swiss-Prot.
DT 08-FEB-2011, sequence version 1.
DT 03-AUG-2022, entry version 58.
DE RecName: Full=Humanin-like 4 {ECO:0000305};
DE Short=HN4 {ECO:0000303|PubMed:19477263};
DE AltName: Full=MT-RNR2-like protein 4 {ECO:0000312|HGNC:HGNC:37161};
GN Name=MTRNR2L4 {ECO:0000312|HGNC:HGNC:37161};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15616553; DOI=10.1038/nature03187;
RA Martin J., Han C., Gordon L.A., Terry A., Prabhakar S., She X., Xie G.,
RA Hellsten U., Chan Y.M., Altherr M., Couronne O., Aerts A., Bajorek E.,
RA Black S., Blumer H., Branscomb E., Brown N.C., Bruno W.J., Buckingham J.M.,
RA Callen D.F., Campbell C.S., Campbell M.L., Campbell E.W., Caoile C.,
RA Challacombe J.F., Chasteen L.A., Chertkov O., Chi H.C., Christensen M.,
RA Clark L.M., Cohn J.D., Denys M., Detter J.C., Dickson M.,
RA Dimitrijevic-Bussod M., Escobar J., Fawcett J.J., Flowers D., Fotopulos D.,
RA Glavina T., Gomez M., Gonzales E., Goodstein D., Goodwin L.A., Grady D.L.,
RA Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Hildebrand C.E.,
RA Huang W., Israni S., Jett J., Jewett P.B., Kadner K., Kimball H.,
RA Kobayashi A., Krawczyk M.-C., Leyba T., Longmire J.L., Lopez F., Lou Y.,
RA Lowry S., Ludeman T., Manohar C.F., Mark G.A., McMurray K.L., Meincke L.J.,
RA Morgan J., Moyzis R.K., Mundt M.O., Munk A.C., Nandkeshwar R.D.,
RA Pitluck S., Pollard M., Predki P., Parson-Quintana B., Ramirez L., Rash S.,
RA Retterer J., Ricke D.O., Robinson D.L., Rodriguez A., Salamov A.,
RA Saunders E.H., Scott D., Shough T., Stallings R.L., Stalvey M.,
RA Sutherland R.D., Tapia R., Tesmer J.G., Thayer N., Thompson L.S., Tice H.,
RA Torney D.C., Tran-Gyamfi M., Tsai M., Ulanovsky L.E., Ustaszewska A.,
RA Vo N., White P.S., Williams A.L., Wills P.L., Wu J.-R., Wu K., Yang J.,
RA DeJong P., Bruce D., Doggett N.A., Deaven L., Schmutz J., Grimwood J.,
RA Richardson P., Rokhsar D.S., Eichler E.E., Gilna P., Lucas S.M.,
RA Myers R.M., Rubin E.M., Pennacchio L.A.;
RT "The sequence and analysis of duplication-rich human chromosome 16.";
RL Nature 432:988-994(2004).
RN [2]
RP TISSUE SPECIFICITY, AND INDUCTION.
RX PubMed=19477263; DOI=10.1016/j.ygeno.2009.05.006;
RA Bodzioch M., Lapicka-Bodzioch K., Zapala B., Kamysz W., Kiec-Wilk B.,
RA Dembinska-Kiec A.;
RT "Evidence for potential functionality of nuclearly-encoded humanin
RT isoforms.";
RL Genomics 94:247-256(2009).
CC -!- FUNCTION: Plays a role as a neuroprotective and antiapoptotic factor.
CC {ECO:0000250|UniProtKB:Q8IVG9}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:Q8IVG9}.
CC Cytoplasm {ECO:0000250|UniProtKB:Q8IVG9}.
CC -!- TISSUE SPECIFICITY: Highly expressed in testis. Also expressed in
CC kidney, heart, skeletal muscles and brain.
CC {ECO:0000269|PubMed:19477263}.
CC -!- INDUCTION: Expression is not affected following staurosporine (STS)
CC treatment. Down-regulated 6 hours following beta-carotene treatment,
CC remains down-regulated 24 hours following beta-carotene treatment.
CC {ECO:0000269|PubMed:19477263}.
CC -!- SIMILARITY: Belongs to the humanin family. {ECO:0000305}.
CC -!- CAUTION: The humanin peptide has been shown to be biologically active
CC but is the product of a mitochondrial gene, MT-RNR2. The mechanisms
CC allowing the production and the secretion of humanin from the
CC mitochondrial gene remaining unclear, the possibility exist that the
CC physiologically active humanin peptide is encoded by one of the related
CC genes present in the nuclear genome including the one described here
CC (PubMed:19477263). {ECO:0000305|PubMed:19477263}.
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DR EMBL; AC025283; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; NP_001177405.1; NM_001190476.1.
DR AlphaFoldDB; P0CJ71; -.
DR STRING; 9606.ENSP00000382856; -.
DR BioMuta; MTRNR2L4; -.
DR PaxDb; P0CJ71; -.
DR PRIDE; P0CJ71; -.
DR DNASU; 100463285; -.
DR Ensembl; ENST00000399974.5; ENSP00000382856.3; ENSG00000232196.4.
DR GeneID; 100463285; -.
DR UCSC; uc021tce.2; human.
DR CTD; 100463285; -.
DR GeneCards; MTRNR2L4; -.
DR HGNC; HGNC:37161; MTRNR2L4.
DR HPA; ENSG00000232196; Tissue enriched (skeletal).
DR neXtProt; NX_P0CJ71; -.
DR OpenTargets; ENSG00000232196; -.
DR VEuPathDB; HostDB:ENSG00000232196; -.
DR GeneTree; ENSGT00940000167123; -.
DR HOGENOM; CLU_221584_0_0_1; -.
DR InParanoid; P0CJ71; -.
DR PhylomeDB; P0CJ71; -.
DR PathwayCommons; P0CJ71; -.
DR SignaLink; P0CJ71; -.
DR BioGRID-ORCS; 100463285; 10 hits in 528 CRISPR screens.
DR ChiTaRS; MTRNR2L4; human.
DR Pharos; P0CJ71; Tdark.
DR PRO; PR:P0CJ71; -.
DR Proteomes; UP000005640; Chromosome 16.
DR Bgee; ENSG00000232196; Expressed in stromal cell of endometrium and 82 other tissues.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0048019; F:receptor antagonist activity; IBA:GO_Central.
DR GO; GO:1900118; P:negative regulation of execution phase of apoptosis; IBA:GO_Central.
DR CDD; cd20245; humanin; 1.
DR InterPro; IPR028139; Humanin.
DR PANTHER; PTHR33895; PTHR33895; 1.
DR Pfam; PF15040; Humanin; 1.
PE 2: Evidence at transcript level;
KW Cytoplasm; Reference proteome; Secreted.
FT CHAIN 1..28
FT /note="Humanin-like 4"
FT /id="PRO_0000404553"
SQ SEQUENCE 28 AA; 3247 MW; 235503E7FE3B777A CRC64;
MATQGFSCLL LSVSEIDLSM KRQYKQIR
