HMN5_HUMAN
ID HMN5_HUMAN Reviewed; 24 AA.
AC P0CJ72;
DT 08-FEB-2011, integrated into UniProtKB/Swiss-Prot.
DT 08-FEB-2011, sequence version 1.
DT 03-AUG-2022, entry version 59.
DE RecName: Full=Humanin-like 5 {ECO:0000305};
DE Short=HN5 {ECO:0000303|PubMed:19477263};
DE AltName: Full=MT-RNR2-like protein 5 {ECO:0000312|HGNC:HGNC:37162};
GN Name=MTRNR2L5 {ECO:0000312|HGNC:HGNC:37162};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15164054; DOI=10.1038/nature02462;
RA Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L.,
RA Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K.,
RA Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L.,
RA Taylor A., Battles J., Bird C.P., Ainscough R., Almeida J.P.,
RA Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J.,
RA Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y.,
RA Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P.,
RA Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N.,
RA Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A.,
RA Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C.,
RA Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D.,
RA Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C.,
RA Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K.,
RA Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A.,
RA Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S.,
RA McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S.,
RA Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V.,
RA Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A.,
RA Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M.,
RA Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A.,
RA Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P.,
RA Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y.,
RA Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D.,
RA Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.;
RT "The DNA sequence and comparative analysis of human chromosome 10.";
RL Nature 429:375-381(2004).
RN [2]
RP FUNCTION, SYNTHESIS, TISSUE SPECIFICITY, INDUCTION, AND VARIANT ILE-13.
RX PubMed=19477263; DOI=10.1016/j.ygeno.2009.05.006;
RA Bodzioch M., Lapicka-Bodzioch K., Zapala B., Kamysz W., Kiec-Wilk B.,
RA Dembinska-Kiec A.;
RT "Evidence for potential functionality of nuclearly-encoded humanin
RT isoforms.";
RL Genomics 94:247-256(2009).
CC -!- FUNCTION: Plays a role as a neuroprotective and antiapoptotic factor.
CC {ECO:0000250|UniProtKB:Q8IVG9, ECO:0000269|PubMed:19477263}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:Q8IVG9}.
CC Cytoplasm {ECO:0000250|UniProtKB:Q8IVG9}.
CC -!- TISSUE SPECIFICITY: Expressed in testis and brain.
CC {ECO:0000269|PubMed:19477263}.
CC -!- INDUCTION: Down-regulated 6 hours following staurosporine (STS)
CC treatment and up-regulated 24 hours following STS treatment. Down-
CC regulated 6 hours following beta-carotene treatment, remains down-
CC regulated 24 hours following beta-carotene treatment.
CC {ECO:0000269|PubMed:19477263}.
CC -!- SIMILARITY: Belongs to the humanin family. {ECO:0000305}.
CC -!- CAUTION: The humanin peptide has been shown to be biologically active
CC but is the product of a mitochondrial gene, MT-RNR2. The mechanisms
CC allowing the production and the secretion of humanin from the
CC mitochondrial gene remaining unclear, the possibility exist that the
CC physiologically active humanin peptide is encoded by one of the related
CC genes present in the nuclear genome including the one described here
CC (PubMed:19477263). {ECO:0000305|PubMed:19477263}.
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DR EMBL; AC074322; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; NP_001177407.1; NM_001190478.1.
DR AlphaFoldDB; P0CJ72; -.
DR STRING; 9606.ENSP00000437910; -.
DR BioMuta; MTRNR2L5; -.
DR PaxDb; P0CJ72; -.
DR PRIDE; P0CJ72; -.
DR DNASU; 100463289; -.
DR Ensembl; ENST00000512524.4; ENSP00000437910.1; ENSG00000249860.4.
DR GeneID; 100463289; -.
DR UCSC; uc021pra.2; human.
DR CTD; 100463289; -.
DR GeneCards; MTRNR2L5; -.
DR HGNC; HGNC:37162; MTRNR2L5.
DR HPA; ENSG00000249860; Tissue enhanced (brain).
DR neXtProt; NX_P0CJ72; -.
DR OpenTargets; ENSG00000249860; -.
DR VEuPathDB; HostDB:ENSG00000249860; -.
DR GeneTree; ENSGT00940000167123; -.
DR HOGENOM; CLU_221584_0_0_1; -.
DR InParanoid; P0CJ72; -.
DR PhylomeDB; P0CJ72; -.
DR PathwayCommons; P0CJ72; -.
DR BioGRID-ORCS; 100463289; 9 hits in 611 CRISPR screens.
DR Pharos; P0CJ72; Tbio.
DR PRO; PR:P0CJ72; -.
DR Proteomes; UP000005640; Chromosome 10.
DR Bgee; ENSG00000249860; Expressed in adrenal tissue and 38 other tissues.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0005739; C:mitochondrion; IEA:GOC.
DR GO; GO:0048019; F:receptor antagonist activity; IBA:GO_Central.
DR GO; GO:0072734; P:cellular response to staurosporine; IMP:UniProtKB.
DR GO; GO:1900118; P:negative regulation of execution phase of apoptosis; IMP:UniProtKB.
DR GO; GO:1902109; P:negative regulation of mitochondrial membrane permeability involved in apoptotic process; IMP:UniProtKB.
DR CDD; cd20245; humanin; 1.
DR InterPro; IPR028139; Humanin.
DR PANTHER; PTHR33895; PTHR33895; 1.
DR Pfam; PF15040; Humanin; 1.
PE 2: Evidence at transcript level;
KW Cytoplasm; Reference proteome; Secreted.
FT CHAIN 1..24
FT /note="Humanin-like 5"
FT /id="PRO_0000404554"
FT VARIANT 13
FT /note="T -> I (decreased cytoprotective action;
FT dbSNP:rs11004928)"
FT /evidence="ECO:0000269|PubMed:19477263"
FT /id="VAR_064548"
SQ SEQUENCE 24 AA; 2666 MW; 17A9A778E35134B1 CRC64;
MATPGFSCLL LSTSEIDLPM KRRV
