ID   HMN6_HUMAN              Reviewed;          24 AA.
AC   P0CJ73;
DT   08-FEB-2011, integrated into UniProtKB/Swiss-Prot.
DT   08-FEB-2011, sequence version 1.
DT   03-AUG-2022, entry version 61.
DE   RecName: Full=Humanin-like 6 {ECO:0000305};
DE            Short=HN6 {ECO:0000303|PubMed:19477263};
DE   AltName: Full=MT-RNR2-like protein 6 {ECO:0000312|HGNC:HGNC:37163};
GN   Name=MTRNR2L6 {ECO:0000312|HGNC:HGNC:37163};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=12853948; DOI=10.1038/nature01782;
RA   Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H.,
RA   Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K.,
RA   Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A.,
RA   Delehaunty K.D., Miner T.L., Nash W.E., Cordes M., Du H., Sun H.,
RA   Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A.,
RA   Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P.,
RA   Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M.,
RA   Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S.,
RA   Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R.,
RA   Strowmatt C., Latreille P., Miller N., Johnson D., Murray J.,
RA   Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W.,
RA   Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E.,
RA   Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A.,
RA   Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E.,
RA   Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E.,
RA   Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A.,
RA   Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A.,
RA   Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R.,
RA   McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H.,
RA   Wilson R.K.;
RT   "The DNA sequence of human chromosome 7.";
RL   Nature 424:157-164(2003).
RN   [2]
RP   TISSUE SPECIFICITY, AND INDUCTION.
RX   PubMed=19477263; DOI=10.1016/j.ygeno.2009.05.006;
RA   Bodzioch M., Lapicka-Bodzioch K., Zapala B., Kamysz W., Kiec-Wilk B.,
RA   Dembinska-Kiec A.;
RT   "Evidence for potential functionality of nuclearly-encoded humanin
RT   isoforms.";
RL   Genomics 94:247-256(2009).
CC   -!- FUNCTION: Plays a role as a neuroprotective and antiapoptotic factor.
CC       {ECO:0000250|UniProtKB:Q8IVG9}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:Q8IVG9}.
CC       Cytoplasm {ECO:0000250|UniProtKB:Q8IVG9}.
CC   -!- TISSUE SPECIFICITY: Expressed in skeletal muscle and testis.
CC       {ECO:0000269|PubMed:19477263}.
CC   -!- INDUCTION: Down-regulated 6 hours following staurosporine (STS)
CC       treatment and up-regulated 24 hours following STS treatment. Down-
CC       regulated 6 hours following beta-carotene treatment, returning to its
CC       basal level 24 hours following beta-carotene treatment.
CC       {ECO:0000269|PubMed:19477263}.
CC   -!- SIMILARITY: Belongs to the humanin family. {ECO:0000305}.
CC   -!- CAUTION: The humanin peptide has been shown to be biologically active
CC       but is the product of a mitochondrial gene, MT-RNR2. The mechanisms
CC       allowing the production and the secretion of humanin from the
CC       mitochondrial gene remaining unclear, the possibility exist that the
CC       physiologically active humanin peptide is encoded by one of the related
CC       genes present in the nuclear genome including the one described here
CC       (PubMed:19477263). {ECO:0000305|PubMed:19477263}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AC231380; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; NP_001177416.1; NM_001190487.2.
DR   AlphaFoldDB; P0CJ73; -.
DR   STRING; 9606.ENSP00000473686; -.
DR   BioMuta; MTRNR2L6; -.
DR   PRIDE; P0CJ73; -.
DR   DNASU; 100463482; -.
DR   Ensembl; ENST00000604952.1; ENSP00000473686.1; ENSG00000270672.1.
DR   Ensembl; ENST00000633925.1; ENSP00000488809.1; ENSG00000282017.1.
DR   GeneID; 100463482; -.
DR   UCSC; uc003vzz.3; human.
DR   CTD; 100463482; -.
DR   GeneCards; MTRNR2L6; -.
DR   HGNC; HGNC:37163; MTRNR2L6.
DR   HPA; ENSG00000270672; Tissue enhanced (brain, choroid plexus, skeletal muscle).
DR   neXtProt; NX_P0CJ73; -.
DR   OpenTargets; ENSG00000270672; -.
DR   VEuPathDB; HostDB:ENSG00000270672; -.
DR   GeneTree; ENSGT01020000230765; -.
DR   HOGENOM; CLU_221584_0_0_1; -.
DR   PhylomeDB; P0CJ73; -.
DR   PathwayCommons; P0CJ73; -.
DR   BioGRID-ORCS; 100463482; 23 hits in 601 CRISPR screens.
DR   ChiTaRS; MTRNR2L6; human.
DR   Pharos; P0CJ73; Tdark.
DR   PRO; PR:P0CJ73; -.
DR   Proteomes; UP000005640; Chromosome 7.
DR   Bgee; ENSG00000270672; Expressed in hindlimb stylopod muscle and 82 other tissues.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0048019; F:receptor antagonist activity; IBA:GO_Central.
DR   GO; GO:1900118; P:negative regulation of execution phase of apoptosis; IBA:GO_Central.
DR   CDD; cd20245; humanin; 1.
DR   InterPro; IPR028139; Humanin.
DR   PANTHER; PTHR33895; PTHR33895; 1.
DR   Pfam; PF15040; Humanin; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Reference proteome; Secreted.
FT   CHAIN           1..24
FT                   /note="Humanin-like 6"
FT                   /id="PRO_0000404555"
SQ   SEQUENCE   24 AA;  2719 MW;  FBE0A778F77FA270 CRC64;
     MTPRGFSCLL LPTSETDLPV KRRT