HMN7_HUMAN
ID HMN7_HUMAN Reviewed; 24 AA.
AC P0CJ74;
DT 08-FEB-2011, integrated into UniProtKB/Swiss-Prot.
DT 08-FEB-2011, sequence version 1.
DT 03-AUG-2022, entry version 56.
DE RecName: Full=Humanin-like 7 {ECO:0000305};
DE Short=HN7 {ECO:0000303|PubMed:19477263};
DE AltName: Full=MT-RNR2-like protein 7 {ECO:0000312|HGNC:HGNC:37164};
GN Name=MTRNR2L7 {ECO:0000312|HGNC:HGNC:37164};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15164054; DOI=10.1038/nature02462;
RA Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L.,
RA Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K.,
RA Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L.,
RA Taylor A., Battles J., Bird C.P., Ainscough R., Almeida J.P.,
RA Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J.,
RA Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y.,
RA Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P.,
RA Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N.,
RA Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A.,
RA Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C.,
RA Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D.,
RA Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C.,
RA Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K.,
RA Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A.,
RA Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S.,
RA McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S.,
RA Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V.,
RA Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A.,
RA Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M.,
RA Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A.,
RA Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P.,
RA Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y.,
RA Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D.,
RA Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.;
RT "The DNA sequence and comparative analysis of human chromosome 10.";
RL Nature 429:375-381(2004).
RN [2]
RP TISSUE SPECIFICITY, AND INDUCTION.
RX PubMed=19477263; DOI=10.1016/j.ygeno.2009.05.006;
RA Bodzioch M., Lapicka-Bodzioch K., Zapala B., Kamysz W., Kiec-Wilk B.,
RA Dembinska-Kiec A.;
RT "Evidence for potential functionality of nuclearly-encoded humanin
RT isoforms.";
RL Genomics 94:247-256(2009).
CC -!- FUNCTION: Plays a role as a neuroprotective and antiapoptotic factor.
CC {ECO:0000250|UniProtKB:Q8IVG9}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:Q8IVG9}.
CC Cytoplasm {ECO:0000250|UniProtKB:Q8IVG9}.
CC -!- TISSUE SPECIFICITY: Expressed in testis. {ECO:0000269|PubMed:19477263}.
CC -!- INDUCTION: Down-regulated 6 hours following staurosporine (STS)
CC treatment and up-regulated 24 hours following STS treatment. Down-
CC regulated 6 hours following beta-carotene treatment, returning to its
CC basal level 24 hours following beta-carotene treatment.
CC {ECO:0000269|PubMed:19477263}.
CC -!- SIMILARITY: Belongs to the humanin family. {ECO:0000305}.
CC -!- CAUTION: The humanin peptide has been shown to be biologically active
CC but is the product of a mitochondrial gene, MT-RNR2. The mechanisms
CC allowing the production and the secretion of humanin from the
CC mitochondrial gene remaining unclear, the possibility exist that the
CC physiologically active humanin peptide is encoded by one of the related
CC genes present in the nuclear genome including the one described here
CC (PubMed:19477263). {ECO:0000305|PubMed:19477263}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AL121927; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; NP_001177418.1; NM_001190489.1.
DR AlphaFoldDB; P0CJ74; -.
DR STRING; 9606.ENSP00000439985; -.
DR iPTMnet; P0CJ74; -.
DR PhosphoSitePlus; P0CJ74; -.
DR BioMuta; MTRNR2L7; -.
DR PaxDb; P0CJ74; -.
DR PRIDE; P0CJ74; -.
DR DNASU; 100288485; -.
DR Ensembl; ENST00000544824.2; ENSP00000439985.1; ENSG00000256892.2.
DR GeneID; 100288485; -.
DR UCSC; uc021ppd.2; human.
DR CTD; 100288485; -.
DR GeneCards; MTRNR2L7; -.
DR HGNC; HGNC:37164; MTRNR2L7.
DR HPA; ENSG00000256892; Tissue enriched (brain).
DR neXtProt; NX_P0CJ74; -.
DR OpenTargets; ENSG00000256892; -.
DR VEuPathDB; HostDB:ENSG00000256892; -.
DR GeneTree; ENSGT01040000240869; -.
DR HOGENOM; CLU_221584_0_0_1; -.
DR InParanoid; P0CJ74; -.
DR PhylomeDB; P0CJ74; -.
DR PathwayCommons; P0CJ74; -.
DR SignaLink; P0CJ74; -.
DR BioGRID-ORCS; 100288485; 9 hits in 614 CRISPR screens.
DR ChiTaRS; MTRNR2L7; human.
DR Pharos; P0CJ74; Tdark.
DR PRO; PR:P0CJ74; -.
DR Proteomes; UP000005640; Chromosome 10.
DR Bgee; ENSG00000256892; Expressed in sural nerve and 39 other tissues.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0048019; F:receptor antagonist activity; IBA:GO_Central.
DR GO; GO:1900118; P:negative regulation of execution phase of apoptosis; IBA:GO_Central.
DR CDD; cd20245; humanin; 1.
DR InterPro; IPR028139; Humanin.
DR PANTHER; PTHR33895; PTHR33895; 1.
DR Pfam; PF15040; Humanin; 1.
PE 2: Evidence at transcript level;
KW Cytoplasm; Reference proteome; Secreted.
FT CHAIN 1..24
FT /note="Humanin-like 7"
FT /id="PRO_0000404556"
SQ SEQUENCE 24 AA; 2647 MW; 0521ACE7DE17B4B1 CRC64;
MATGGFGCLL LLIREIDLSV KRQI
