ID   HMN8_HUMAN              Reviewed;          24 AA.
AC   P0CJ75;
DT   08-FEB-2011, integrated into UniProtKB/Swiss-Prot.
DT   08-FEB-2011, sequence version 1.
DT   03-AUG-2022, entry version 63.
DE   RecName: Full=Humanin-like 8 {ECO:0000305};
DE            Short=HN8 {ECO:0000303|PubMed:19477263};
DE   AltName: Full=MT-RNR2-like protein 8 {ECO:0000312|HGNC:HGNC:37165};
GN   Name=MTRNR2L8 {ECO:0000312|HGNC:HGNC:37165};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16554811; DOI=10.1038/nature04632;
RA   Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K.,
RA   Lloyd C., Itoh T., Takeda T., Kim D.-W., She X., Barlow K.F., Bloom T.,
RA   Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G.,
RA   Jaffe D.B., LaButti K., Nicol R., Park H.-S., Seaman C., Sougnez C.,
RA   Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A.,
RA   Hattori M., Rogers J., Lander E.S., Sakaki Y.;
RT   "Human chromosome 11 DNA sequence and analysis including novel gene
RT   identification.";
RL   Nature 440:497-500(2006).
RN   [2]
RP   TISSUE SPECIFICITY, AND INDUCTION.
RX   PubMed=19477263; DOI=10.1016/j.ygeno.2009.05.006;
RA   Bodzioch M., Lapicka-Bodzioch K., Zapala B., Kamysz W., Kiec-Wilk B.,
RA   Dembinska-Kiec A.;
RT   "Evidence for potential functionality of nuclearly-encoded humanin
RT   isoforms.";
RL   Genomics 94:247-256(2009).
CC   -!- FUNCTION: Plays a role as a neuroprotective and antiapoptotic factor.
CC       {ECO:0000250|UniProtKB:Q8IVG9}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:Q8IVG9}.
CC       Cytoplasm {ECO:0000250|UniProtKB:Q8IVG9}.
CC   -!- TISSUE SPECIFICITY: Highly expressed in the kidney, heart muscle and
CC       testis. Not expressed in skeletal muscle.
CC       {ECO:0000269|PubMed:19477263}.
CC   -!- INDUCTION: Down-regulated 6 hours following staurosporine (STS)
CC       treatment and up-regulated 24 hours following STS treatment. Down-
CC       regulated 6 hours following beta-carotene treatment, returning to its
CC       basal level 24 hours following beta-carotene treatment.
CC       {ECO:0000269|PubMed:19477263}.
CC   -!- SIMILARITY: Belongs to the humanin family. {ECO:0000305}.
CC   -!- CAUTION: The humanin peptide has been shown to be biologically active
CC       but is the product of a mitochondrial gene, MT-RNR2. The mechanisms
CC       allowing the production and the secretion of humanin from the
CC       mitochondrial gene remaining unclear, the possibility exist that the
CC       physiologically active humanin peptide is encoded by one of the related
CC       genes present in the nuclear genome including the one described here
CC       (PubMed:19477263). {ECO:0000305|PubMed:19477263}.
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DR   EMBL; AC021914; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; NP_001177631.1; NM_001190702.1.
DR   AlphaFoldDB; P0CJ75; -.
DR   BioGRID; 1148186; 2.
DR   STRING; 9606.ENSP00000439666; -.
DR   BioMuta; MTRNR2L8; -.
DR   PaxDb; P0CJ75; -.
DR   PRIDE; P0CJ75; -.
DR   DNASU; 100463486; -.
DR   Ensembl; ENST00000536684.3; ENSP00000439666.1; ENSG00000255823.5.
DR   GeneID; 100463486; -.
DR   UCSC; uc001miq.5; human.
DR   CTD; 100463486; -.
DR   DisGeNET; 100463486; -.
DR   GeneCards; MTRNR2L8; -.
DR   HGNC; HGNC:37165; MTRNR2L8.
DR   HPA; ENSG00000255823; Tissue enhanced (brain, choroid plexus, skeletal muscle).
DR   neXtProt; NX_P0CJ75; -.
DR   OpenTargets; ENSG00000255823; -.
DR   OpenTargets; ENSG00000269028; -.
DR   VEuPathDB; HostDB:ENSG00000255823; -.
DR   HOGENOM; CLU_221584_0_0_1; -.
DR   InParanoid; P0CJ75; -.
DR   PhylomeDB; P0CJ75; -.
DR   PathwayCommons; P0CJ75; -.
DR   SignaLink; P0CJ75; -.
DR   BioGRID-ORCS; 100463486; 274 hits in 603 CRISPR screens.
DR   ChiTaRS; MTRNR2L8; human.
DR   Pharos; P0CJ75; Tdark.
DR   PRO; PR:P0CJ75; -.
DR   Proteomes; UP000005640; Chromosome 11.
DR   Bgee; ENSG00000255823; Expressed in sural nerve and 104 other tissues.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0048019; F:receptor antagonist activity; IBA:GO_Central.
DR   GO; GO:1900118; P:negative regulation of execution phase of apoptosis; IBA:GO_Central.
DR   CDD; cd20245; humanin; 1.
DR   InterPro; IPR028139; Humanin.
DR   PANTHER; PTHR33895; PTHR33895; 1.
DR   Pfam; PF15040; Humanin; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Reference proteome; Secreted.
FT   CHAIN           1..24
FT                   /note="Humanin-like 8"
FT                   /id="PRO_0000404557"
SQ   SEQUENCE   24 AA;  2661 MW;  08B9A778F4B0B971 CRC64;
     MAPRGFSCLL LSTSEIDLPV KRRA