HMN9_HUMAN
ID HMN9_HUMAN Reviewed; 24 AA.
AC P0CJ76;
DT 08-FEB-2011, integrated into UniProtKB/Swiss-Prot.
DT 08-FEB-2011, sequence version 1.
DT 03-AUG-2022, entry version 48.
DE RecName: Full=Humanin-like 9 {ECO:0000305};
DE Short=HN9 {ECO:0000303|PubMed:19477263};
DE AltName: Full=MT-RNR2-like protein 9 {ECO:0000312|HGNC:HGNC:37166};
GN Name=MTRNR2L9 {ECO:0000312|HGNC:HGNC:37166};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=14574404; DOI=10.1038/nature02055;
RA Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L.,
RA Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R.,
RA Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D.,
RA Andrews T.D., Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J.,
RA Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H.,
RA Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J.,
RA Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P.,
RA Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V.,
RA Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J.,
RA Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E.,
RA Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J.,
RA French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J.,
RA Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C.,
RA Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A.,
RA Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R.,
RA Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M.,
RA Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K.,
RA Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R.,
RA Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M.,
RA Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A.,
RA Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L.,
RA Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I.,
RA Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y.,
RA Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E.,
RA Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A.,
RA Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W.,
RA Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M.,
RA West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J.,
RA Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M.,
RA Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I.,
RA Rogers J., Beck S.;
RT "The DNA sequence and analysis of human chromosome 6.";
RL Nature 425:805-811(2003).
RN [2]
RP TISSUE SPECIFICITY, AND INDUCTION.
RX PubMed=19477263; DOI=10.1016/j.ygeno.2009.05.006;
RA Bodzioch M., Lapicka-Bodzioch K., Zapala B., Kamysz W., Kiec-Wilk B.,
RA Dembinska-Kiec A.;
RT "Evidence for potential functionality of nuclearly-encoded humanin
RT isoforms.";
RL Genomics 94:247-256(2009).
CC -!- FUNCTION: Plays a role as a neuroprotective and antiapoptotic factor.
CC {ECO:0000250|UniProtKB:Q8IVG9}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:Q8IVG9}.
CC Cytoplasm {ECO:0000250|UniProtKB:Q8IVG9}.
CC -!- TISSUE SPECIFICITY: Highly expressed in the kidney, heart muscle and
CC testis. {ECO:0000269|PubMed:19477263}.
CC -!- INDUCTION: Down-regulated 6 hours following staurosporine (STS)
CC treatment and up-regulated 24 hours following STS treatment. Down-
CC regulated 6 hours following beta-carotene treatment, returning to its
CC basal level 24 hours following beta-carotene treatment.
CC {ECO:0000269|PubMed:19477263}.
CC -!- SIMILARITY: Belongs to the humanin family. {ECO:0000305}.
CC -!- CAUTION: The humanin peptide has been shown to be biologically active
CC but is the product of a mitochondrial gene, MT-RNR2. The mechanisms
CC allowing the production and the secretion of humanin from the
CC mitochondrial gene remaining unclear, the possibility exist that the
CC physiologically active humanin peptide is encoded by one of the related
CC genes present in the nuclear genome including the one described here
CC (PubMed:19477263). {ECO:0000305|PubMed:19477263}.
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DR EMBL; AL356135; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; NP_001177635.1; NM_001190706.1.
DR AlphaFoldDB; P0CJ76; -.
DR STRING; 9606.ENSP00000474840; -.
DR BioMuta; HGNC:37166; -.
DR PRIDE; P0CJ76; -.
DR DNASU; 100463487; -.
DR GeneID; 100463487; -.
DR UCSC; uc032wzo.1; human.
DR CTD; 100463487; -.
DR GeneCards; MTRNR2L9; -.
DR HGNC; HGNC:37166; MTRNR2L9.
DR neXtProt; NX_P0CJ76; -.
DR OrthoDB; 1012406at2759; -.
DR PhylomeDB; P0CJ76; -.
DR PathwayCommons; P0CJ76; -.
DR BioGRID-ORCS; 100463487; 4 hits in 489 CRISPR screens.
DR ChiTaRS; MTRNR2L9; human.
DR Pharos; P0CJ76; Tdark.
DR PRO; PR:P0CJ76; -.
DR Proteomes; UP000005640; Unplaced.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0048019; F:receptor antagonist activity; IBA:GO_Central.
DR GO; GO:1900118; P:negative regulation of execution phase of apoptosis; IBA:GO_Central.
DR CDD; cd20245; humanin; 1.
DR InterPro; IPR028139; Humanin.
DR PANTHER; PTHR33895; PTHR33895; 1.
DR Pfam; PF15040; Humanin; 1.
PE 2: Evidence at transcript level;
KW Cytoplasm; Reference proteome; Secreted.
FT CHAIN 1..24
FT /note="Humanin-like 9"
FT /id="PRO_0000404558"
SQ SEQUENCE 24 AA; 2694 MW; 0EE5B5A3F4B30F91 CRC64;
MARRGFSCLL LSTTATDLPV KRRT
