HMO1_CANAL
ID HMO1_CANAL Reviewed; 223 AA.
AC Q59PR9; A0A1D8PT14;
DT 16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT 26-APR-2005, sequence version 1.
DT 03-AUG-2022, entry version 100.
DE RecName: Full=Transcriptional regulator HMO1;
DE AltName: Full=High mobility group protein 1;
GN Name=HMO1; OrderedLocusNames=CAALFM_CR05670CA;
GN ORFNames=CaO19.13966, CaO19.6645;
OS Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Debaryomycetaceae; Candida/Lodderomyces clade; Candida.
OX NCBI_TaxID=237561;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SC5314 / ATCC MYA-2876;
RX PubMed=15123810; DOI=10.1073/pnas.0401648101;
RA Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B.,
RA Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W.,
RA Scherer S.;
RT "The diploid genome sequence of Candida albicans.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=SC5314 / ATCC MYA-2876;
RX PubMed=17419877; DOI=10.1186/gb-2007-8-4-r52;
RA van het Hoog M., Rast T.J., Martchenko M., Grindle S., Dignard D.,
RA Hogues H., Cuomo C., Berriman M., Scherer S., Magee B.B., Whiteway M.,
RA Chibana H., Nantel A., Magee P.T.;
RT "Assembly of the Candida albicans genome into sixteen supercontigs aligned
RT on the eight chromosomes.";
RL Genome Biol. 8:RESEARCH52.1-RESEARCH52.12(2007).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND GENOME REANNOTATION.
RC STRAIN=SC5314 / ATCC MYA-2876;
RX PubMed=24025428; DOI=10.1186/gb-2013-14-9-r97;
RA Muzzey D., Schwartz K., Weissman J.S., Sherlock G.;
RT "Assembly of a phased diploid Candida albicans genome facilitates allele-
RT specific measurements and provides a simple model for repeat and indel
RT structure.";
RL Genome Biol. 14:RESEARCH97.1-RESEARCH97.14(2013).
RN [4]
RP FUNCTION.
RX PubMed=20231876; DOI=10.1371/journal.pbio.1000329;
RA Lavoie H., Hogues H., Mallick J., Sellam A., Nantel A., Whiteway M.;
RT "Evolutionary tinkering with conserved components of a transcriptional
RT regulatory network.";
RL PLoS Biol. 8:E1000329-E1000329(2010).
RN [5]
RP INDUCTION.
RX PubMed=22265407; DOI=10.1016/j.cell.2011.10.048;
RA Nobile C.J., Fox E.P., Nett J.E., Sorrells T.R., Mitrovich Q.M.,
RA Hernday A.D., Tuch B.B., Andes D.R., Johnson A.D.;
RT "A recently evolved transcriptional network controls biofilm development in
RT Candida albicans.";
RL Cell 148:126-138(2012).
CC -!- FUNCTION: Transcription factor that binds upstream of hexose and
CC ergosterol metabolism, as well as cell cycle genes. Activates
CC pseudohyphal growth. {ECO:0000269|PubMed:20231876}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00267}.
CC -!- INDUCTION: Repressed hyphae and in biofilm.
CC {ECO:0000269|PubMed:22265407}.
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DR EMBL; CP017630; AOW31283.1; -; Genomic_DNA.
DR RefSeq; XP_711711.1; XM_706619.1.
DR AlphaFoldDB; Q59PR9; -.
DR SMR; Q59PR9; -.
DR BioGRID; 1229310; 1.
DR STRING; 237561.Q59PR9; -.
DR PRIDE; Q59PR9; -.
DR GeneID; 3646685; -.
DR KEGG; cal:CAALFM_CR05670CA; -.
DR CGD; CAL0000192851; HMO1.
DR VEuPathDB; FungiDB:CR_05670C_A; -.
DR eggNOG; KOG0381; Eukaryota.
DR HOGENOM; CLU_076155_1_0_1; -.
DR InParanoid; Q59PR9; -.
DR OMA; DKWKQAY; -.
DR OrthoDB; 1641977at2759; -.
DR PRO; PR:Q59PR9; -.
DR Proteomes; UP000000559; Chromosome R.
DR GO; GO:0005829; C:cytosol; IEA:EnsemblFungi.
DR GO; GO:0005730; C:nucleolus; IEA:EnsemblFungi.
DR GO; GO:0033553; C:rDNA heterochromatin; IEA:EnsemblFungi.
DR GO; GO:0032040; C:small-subunit processome; IEA:EnsemblFungi.
DR GO; GO:0008301; F:DNA binding, bending; IBA:GO_Central.
DR GO; GO:0003690; F:double-stranded DNA binding; IEA:EnsemblFungi.
DR GO; GO:0000400; F:four-way junction DNA binding; IEA:EnsemblFungi.
DR GO; GO:0044877; F:protein-containing complex binding; IEA:EnsemblFungi.
DR GO; GO:0043565; F:sequence-specific DNA binding; IDA:CGD.
DR GO; GO:0044804; P:autophagy of nucleus; IEA:EnsemblFungi.
DR GO; GO:0006338; P:chromatin remodeling; IEA:EnsemblFungi.
DR GO; GO:0006265; P:DNA topological change; IEA:EnsemblFungi.
DR GO; GO:0044182; P:filamentous growth of a population of unicellular organisms; IMP:CGD.
DR GO; GO:2000134; P:negative regulation of G1/S transition of mitotic cell cycle; IMP:CGD.
DR GO; GO:2001034; P:positive regulation of double-strand break repair via nonhomologous end joining; IEA:EnsemblFungi.
DR GO; GO:0070550; P:rDNA chromatin condensation; IEA:EnsemblFungi.
DR GO; GO:0060962; P:regulation of ribosomal protein gene transcription by RNA polymerase II; IEA:EnsemblFungi.
DR GO; GO:0006356; P:regulation of transcription by RNA polymerase I; IEA:EnsemblFungi.
DR GO; GO:0001174; P:transcriptional start site selection at RNA polymerase II promoter; IEA:EnsemblFungi.
DR Gene3D; 1.10.30.10; -; 1.
DR InterPro; IPR009071; HMG_box_dom.
DR InterPro; IPR036910; HMG_box_dom_sf.
DR Pfam; PF00505; HMG_box; 1.
DR SMART; SM00398; HMG; 1.
DR SUPFAM; SSF47095; SSF47095; 1.
DR PROSITE; PS50118; HMG_BOX_2; 1.
PE 2: Evidence at transcript level;
KW DNA-binding; Nucleus; Reference proteome; Transcription;
KW Transcription regulation.
FT CHAIN 1..223
FT /note="Transcriptional regulator HMO1"
FT /id="PRO_0000426082"
FT DNA_BIND 87..160
FT /note="HMG box"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00267"
FT REGION 69..89
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 165..223
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 70..86
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 208..223
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 223 AA; 24815 MW; 56A59CFEF783C3F6 CRC64;
MSDLKTTKDT LVSTLFELSK AAQDAANAAI EFYKVASGGS DHVSAEQLKA VSEALNTVAT
LSSGNGAKIE ATESKKKRKQ EKDPNAPKKP LTMFFQFSYD LRKKIGIERK KKDLPSLSAI
DMNSMIKDRW DSISEAEKAG YKKRYDDAMI IYNIEKKKYE ESLKDGSAYY PPPSVQTPIV
GHGIEQDFDD DATDIVSSPE EPKKKKKKTE KKEKKKKSGH GSP
