HMOC_DROME
ID HMOC_DROME Reviewed; 542 AA.
AC P22810; Q59E69; Q6NNU8; Q9W3D0;
DT 01-AUG-1991, integrated into UniProtKB/Swiss-Prot.
DT 14-APR-2009, sequence version 2.
DT 03-AUG-2022, entry version 181.
DE RecName: Full=Homeotic protein ocelliless;
DE AltName: Full=Protein orthodenticle;
GN Name=oc; Synonyms=Otd; ORFNames=CG12154;
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY, DEVELOPMENTAL
RP STAGE, AND DISRUPTION PHENOTYPE.
RC TISSUE=Embryo;
RX PubMed=1979296; DOI=10.1101/gad.4.9.1516;
RA Finkelstein R., Smouse D., Capaci T.M., Spradling A.C., Perrimon N.;
RT "The orthodenticle gene encodes a novel homeo domain protein involved in
RT the development of the Drosophila nervous system and ocellar visual
RT structures.";
RL Genes Dev. 4:1516-1527(1990).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley;
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=Berkeley;
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Berkeley; TISSUE=Embryo;
RA Stapleton M., Brokstein P., Hong L., Agbayani A., Carlson J.W., Champe M.,
RA Chavez C., Dorsett V., Dresnek D., Farfan D., Frise E., George R.A.,
RA Gonzalez M., Guarin H., Kronmiller B., Li P.W., Liao G., Miranda A.,
RA Mungall C.J., Nunoo J., Pacleb J.M., Paragas V., Park S., Patel S.,
RA Phouanenavong S., Wan K.H., Yu C., Lewis S.E., Rubin G.M., Celniker S.E.;
RL Submitted (JAN-2004) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP FUNCTION, TISSUE SPECIFICITY, AND DISRUPTION PHENOTYPE.
RX PubMed=8575625; DOI=10.1006/dbio.1996.0020;
RA Vandendries E.R., Johnson D., Reinke R.;
RT "orthodenticle is required for photoreceptor cell development in the
RT Drosophila eye.";
RL Dev. Biol. 173:243-255(1996).
RN [6]
RP FUNCTION, AND TISSUE SPECIFICITY.
RX PubMed=12967559; DOI=10.1016/s1534-5807(03)00239-9;
RA Tahayato A., Sonneville R., Pichaud F., Wernet M.F., Papatsenko D.,
RA Beaufils P., Cook T., Desplan C.;
RT "Otd/Crx, a dual regulator for the specification of ommatidia subtypes in
RT the Drosophila retina.";
RL Dev. Cell 5:391-402(2003).
CC -!- FUNCTION: Transcriptional regulator involved in pattern formation and
CC cell determination in the embryonic CNS and larval imaginal disks. Also
CC later in development to coordinate the expression of regulatory and
CC structural genes required for photoreceptor cell fate in the ocelli.
CC Has a dual role in the terminal differentiation of subtypes of
CC photoreceptors by regulating rhodopsin (rh) expression: essential for
CC establishing the expression of rh genes in the pale subset of ommatidia
CC as well as repressing Rh6 in outer photoreceptors.
CC {ECO:0000269|PubMed:12967559, ECO:0000269|PubMed:1979296,
CC ECO:0000269|PubMed:8575625}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- TISSUE SPECIFICITY: Expressed in the anterior region of the embryo
CC before cellularization and becomes localized to the procephalic head
CC region following gastrulation. These cells correspond to the
CC mesectoderm or midline neuroepithelium and will generate a mixed
CC population of neurons and glia. Expressed in photoreceptors in pupae
CC and adults. {ECO:0000269|PubMed:12967559, ECO:0000269|PubMed:1979296,
CC ECO:0000269|PubMed:8575625}.
CC -!- DEVELOPMENTAL STAGE: Expressed from early embryonic stages through to
CC late pupation. {ECO:0000269|PubMed:1979296}.
CC -!- DOMAIN: Contains multiple repeats consisting of single amino acids
CC (e.g. Gly, Ser, His, and Asn) and pairs of amino acids (e.g. Gly-Val).
CC -!- DISRUPTION PHENOTYPE: In embryos, formation of an abnormal neuropil and
CC the disappearance of the horizontal commissures associated with the
CC midline of the CNS. In pupae, misshapen, duplicated, and shortened
CC rhabdomeres within the eye. In adults, deletion of the ocelli.
CC {ECO:0000269|PubMed:1979296, ECO:0000269|PubMed:8575625}.
CC -!- SIMILARITY: Belongs to the paired homeobox family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=CAA41732.1; Type=Frameshift; Evidence={ECO:0000305};
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DR EMBL; X58983; CAA41732.1; ALT_FRAME; mRNA.
DR EMBL; AE014298; AAX52481.2; -; Genomic_DNA.
DR EMBL; BT011185; AAR88546.1; -; mRNA.
DR PIR; A35912; A35912.
DR RefSeq; NP_001014727.2; NM_001014727.3.
DR RefSeq; NP_001259345.1; NM_001272416.1.
DR RefSeq; NP_001259346.1; NM_001272417.1.
DR AlphaFoldDB; P22810; -.
DR SMR; P22810; -.
DR BioGRID; 58261; 14.
DR IntAct; P22810; 74.
DR STRING; 7227.FBpp0304126; -.
DR PaxDb; P22810; -.
DR EnsemblMetazoa; FBtr0300106; FBpp0289383; FBgn0004102.
DR EnsemblMetazoa; FBtr0331305; FBpp0303737; FBgn0004102.
DR EnsemblMetazoa; FBtr0331738; FBpp0304127; FBgn0004102.
DR GeneID; 31802; -.
DR KEGG; dme:Dmel_CG12154; -.
DR UCSC; CG12154-RC; d. melanogaster.
DR CTD; 31802; -.
DR FlyBase; FBgn0004102; oc.
DR VEuPathDB; VectorBase:FBgn0004102; -.
DR eggNOG; KOG2251; Eukaryota.
DR GeneTree; ENSGT00940000167436; -.
DR InParanoid; P22810; -.
DR PhylomeDB; P22810; -.
DR SignaLink; P22810; -.
DR BioGRID-ORCS; 31802; 0 hits in 3 CRISPR screens.
DR ChiTaRS; oc; fly.
DR GenomeRNAi; 31802; -.
DR PRO; PR:P22810; -.
DR Proteomes; UP000000803; Chromosome X.
DR Bgee; FBgn0004102; Expressed in procephalic neurogenic region (Drosophila) and 43 other tissues.
DR ExpressionAtlas; P22810; baseline and differential.
DR Genevisible; P22810; DM.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0001228; F:DNA-binding transcription activator activity, RNA polymerase II-specific; IDA:FlyBase.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0046982; F:protein heterodimerization activity; IPI:FlyBase.
DR GO; GO:0042803; F:protein homodimerization activity; IPI:FlyBase.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0007628; P:adult walking behavior; TAS:FlyBase.
DR GO; GO:0035288; P:anterior head segmentation; TAS:FlyBase.
DR GO; GO:0007355; P:anterior region determination; TAS:FlyBase.
DR GO; GO:0007420; P:brain development; IMP:FlyBase.
DR GO; GO:0035284; P:brain segmentation; IMP:FlyBase.
DR GO; GO:0007417; P:central nervous system development; IMP:UniProtKB.
DR GO; GO:0001745; P:compound eye morphogenesis; IMP:UniProtKB.
DR GO; GO:0042051; P:compound eye photoreceptor development; IMP:FlyBase.
DR GO; GO:0001700; P:embryonic development via the syncytial blastoderm; IMP:FlyBase.
DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IMP:FlyBase.
DR GO; GO:0007399; P:nervous system development; TAS:FlyBase.
DR GO; GO:0008056; P:ocellus development; IGI:FlyBase.
DR GO; GO:0048816; P:ocellus morphogenesis; NAS:FlyBase.
DR GO; GO:0042463; P:ocellus photoreceptor cell development; IGI:FlyBase.
DR GO; GO:0007389; P:pattern specification process; NAS:FlyBase.
DR GO; GO:0046552; P:photoreceptor cell fate commitment; IMP:UniProtKB.
DR GO; GO:0045315; P:positive regulation of compound eye photoreceptor development; IMP:FlyBase.
DR GO; GO:0010628; P:positive regulation of gene expression; IMP:FlyBase.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IDA:FlyBase.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0042052; P:rhabdomere development; IMP:UniProtKB.
DR GO; GO:0061541; P:rhabdomere morphogenesis; IMP:FlyBase.
DR GO; GO:0007419; P:ventral cord development; IMP:FlyBase.
DR CDD; cd00086; homeodomain; 1.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR017970; Homeobox_CS.
DR InterPro; IPR001356; Homeobox_dom.
DR Pfam; PF00046; Homeodomain; 1.
DR SMART; SM00389; HOX; 1.
DR SUPFAM; SSF46689; SSF46689; 1.
DR PROSITE; PS00027; HOMEOBOX_1; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
PE 2: Evidence at transcript level;
KW Developmental protein; DNA-binding; Homeobox; Nucleus; Reference proteome;
KW Repeat; Transcription; Transcription regulation.
FT CHAIN 1..542
FT /note="Homeotic protein ocelliless"
FT /id="PRO_0000049072"
FT DNA_BIND 67..126
FT /note="Homeobox"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT REGION 1..40
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 124..209
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 243..278
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 392..441
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 26..40
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 243..274
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 398..419
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 61
FT /note="G -> GDLCYPG (in Ref. 1; CAA41732)"
FT /evidence="ECO:0000305"
FT CONFLICT 240
FT /note="A -> ASAQSIKTHHSSFLSAAAA (in Ref. 1; CAA41732)"
FT /evidence="ECO:0000305"
FT CONFLICT 272..273
FT /note="Missing (in Ref. 1; CAA41732)"
FT /evidence="ECO:0000305"
FT CONFLICT 337
FT /note="G -> GGG (in Ref. 1; CAA41732)"
FT /evidence="ECO:0000305"
FT CONFLICT 434
FT /note="Missing (in Ref. 1; CAA41732)"
FT /evidence="ECO:0000305"
FT CONFLICT 530
FT /note="D -> Y (in Ref. 4; AAR88546)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 542 AA; 55187 MW; 73F6795CD8171EA0 CRC64;
MAAGFLKSGD LGPHPHSYGG PHPHHSVPHG PLPPGMPMPS LGPFGLPHGL EAVGFSQGMW
GVNTRKQRRE RTTFTRAQLD VLEALFGKTR YPDIFMREEV ALKINLPESR VQVWFKNRRA
KCRQQLQQQQ QSNSLSSSKN ASGGGSGNSC SSSSANSRSN SNNNGSSSNN NTQSSGGNNS
NKSSQKQGNS QSSQQGGGSS GGNNSNNNSA AAAASAAAAV AAAQSIKTHH SSFLSAAAAA
ASGGTNQSAN NNSNNNNQGN STPNSSSSGG GGGSQAGGHL SAAAAAAALN VTAAHQNSSP
LLPTPATSVS PVSIVCKKEH LSGGYGSSVG GGGGGGGASS GGLNLGVGVG VGVGVGVGVS
QDLLRSPYDQ LKDAGGDIGA GVHHHHSIYG SAAGSNPRLL QPGGNITPMD SSSSITTPSP
PITPMSPQSA AAAAHAAQSA QSAHHSAAHS AAYMSNHDSY NFWHNQYQQY PNNYAQAPSY
YSQMEYFSNQ NQVNYNMGHS GYTASNFGLS PSPSFTGTVS AQAFSQNSLD YMSPQDKYAN
MV
