ID   1101L_ASFB7             Reviewed;         270 AA.
AC   P18560;
DT   01-NOV-1990, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1990, sequence version 1.
DT   03-AUG-2022, entry version 72.
DE   RecName: Full=Protein MGF 110-1L;
DE   Flags: Precursor;
GN   OrderedLocusNames=BA71V-008; ORFNames=L270L;
OS   African swine fever virus (strain Badajoz 1971 Vero-adapted) (Ba71V)
OS   (ASFV).
OC   Viruses; Varidnaviria; Bamfordvirae; Nucleocytoviricota; Pokkesviricetes;
OC   Asfuvirales; Asfarviridae; Asfivirus.
OX   NCBI_TaxID=10498;
OH   NCBI_TaxID=6937; Ornithodoros (relapsing fever ticks).
OH   NCBI_TaxID=9823; Sus scrofa (Pig).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=2325202; DOI=10.1128/jvi.64.5.2064-2072.1990;
RA   Almendral J.M., Almazan F., Blasco R., Vinuela E.;
RT   "Multigene families in African swine fever virus: family 110.";
RL   J. Virol. 64:2064-2072(1990).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=11831707; DOI=10.1006/viro.1995.1149;
RA   Yanez R.J., Rodriguez J.M., Nogal M.L., Yuste L., Enriquez C.,
RA   Rodriguez J.F., Vinuela E.;
RT   "Analysis of the complete nucleotide sequence of African swine fever
RT   virus.";
RL   Virology 208:249-278(1995).
RN   [3]
RP   INDUCTION.
RX   PubMed=1404609; DOI=10.1128/jvi.66.11.6655-6667.1992;
RA   Almazan F., Rodriguez J.M., Andres G., Perez R., Vinuela E.,
RA   Rodriguez J.F.;
RT   "Transcriptional analysis of multigene family 110 of African swine fever
RT   virus.";
RL   J. Virol. 66:6655-6667(1992).
RN   [4]
RP   INDUCTION.
RX   PubMed=32075923; DOI=10.1128/jvi.00119-20;
RA   Cackett G., Matelska D., Sykora M., Portugal R., Malecki M., Baehler J.,
RA   Dixon L., Werner F.;
RT   "The African Swine Fever Virus Transcriptome.";
RL   J. Virol. 94:0-0(2020).
CC   -!- FUNCTION: Plays a role in virus cell tropism, and may be required for
CC       efficient virus replication in macrophages. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- INDUCTION: Expressed in the immediate early phase of the viral
CC       replicative cycle. {ECO:0000269|PubMed:1404609,
CC       ECO:0000269|PubMed:32075923}.
CC   -!- SIMILARITY: Belongs to the asfivirus MGF 110 family. {ECO:0000305}.
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DR   EMBL; M36467; AAA42688.1; -; Genomic_DNA.
DR   EMBL; U18466; AAA65243.1; -; Genomic_DNA.
DR   PIR; E43702; E43702.
DR   RefSeq; NP_042707.1; NC_001659.2.
DR   GeneID; 22220397; -.
DR   KEGG; vg:22220397; -.
DR   Proteomes; UP000000624; Genome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   InterPro; IPR004848; ASFV_fam_110.
DR   Pfam; PF01639; v110; 2.
PE   2: Evidence at transcript level;
KW   Early protein; Glycoprotein; Membrane; Reference proteome; Repeat; Signal;
KW   Transmembrane; Transmembrane helix.
FT   SIGNAL          1..26
FT                   /evidence="ECO:0000250|UniProtKB:A9JLI2"
FT   CHAIN           27..270
FT                   /note="Protein MGF 110-1L"
FT                   /id="PRO_0000036741"
FT   TOPO_DOM        27..117
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        118..138
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        139..145
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        146..166
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        167..270
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   REPEAT          27..146
FT                   /note="A"
FT   REPEAT          147..270
FT                   /note="B"
FT   CARBOHYD        75
FT                   /note="N-linked (GlcNAc...) asparagine; by host"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   270 AA;  32387 MW;  40A5EE1287210B6E CRC64;
     MLGLQIFTLL SIPTLLYTYE IEPLERTSTP PEKELGYWCT YANHCRFCWD CQDGICRNKA
     FKNHSPILEN NYIANCSIYR RNDFCIYYIT SIKPHKTYRT ECPQHINHER HEADIRKWQK
     LLTYGFYLAG CILAVNYIRK RSLQTVMYLL VFLVISFLLS QLMLYGELED KKHKIGSIPP
     KRELEHWCTH GKYCNFCWDC QNGICKNKAF KNHPPIGEND FIRYDCWTTH LPNKCSYEKI
     YKHFNTHIME CSQPTHFKWY DNLMKKQDIM