ID   3SOI2_BUNFA             Reviewed;          63 AA.
AC   P14534;
DT   01-JAN-1990, integrated into UniProtKB/Swiss-Prot.
DT   01-JAN-1990, sequence version 1.
DT   25-MAY-2022, entry version 81.
DE   RecName: Full=Short neurotoxin 2;
DE   AltName: Full=Fasciatoxin;
DE   AltName: Full=Toxin V-II-2;
OS   Bungarus fasciatus (Banded krait) (Pseudoboa fasciata).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera;
OC   Serpentes; Colubroidea; Elapidae; Bungarinae; Bungarus.
OX   NCBI_TaxID=8613;
RN   [1]
RP   PROTEIN SEQUENCE.
RC   TISSUE=Venom;
RX   PubMed=2719639; DOI=10.1042/bj2590153;
RA   Liu C.-S., Hsiao P.-W., Chang C.-S., Tzeng M.-C., Lo T.-B.;
RT   "Unusual amino acid sequence of fasciatoxin, a weak reversibly acting
RT   neurotoxin in the venom of the banded krait, Bungarus fasciatus.";
RL   Biochem. J. 259:153-158(1989).
CC   -!- FUNCTION: Blocks both the muscle-twitch response to nerve stimulation
CC       and the response to exogenous acetylcholine.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom gland.
CC   -!- MISCELLANEOUS: In contrast to other snake toxins the action of this
CC       toxin is reversible.
CC   -!- MISCELLANEOUS: Unusual amino acid sequence distinctly different from
CC       other short-chain type toxins.
CC   -!- MISCELLANEOUS: Is classified as a P-type cytotoxin, since a proline
CC       residue stands at position 30 (Pro-31 in standard classification).
CC       {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the snake three-finger toxin family. Short-chain
CC       subfamily. Orphan group XVIII sub-subfamily. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   PIR; S03864; S03864.
DR   AlphaFoldDB; P14534; -.
DR   SMR; P14534; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR   Gene3D; 2.10.60.10; -; 1.
DR   InterPro; IPR045860; Snake_toxin-like_sf.
DR   SUPFAM; SSF57302; SSF57302; 1.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Disulfide bond; Neurotoxin;
KW   Postsynaptic neurotoxin; Secreted; Toxin.
FT   CHAIN           1..63
FT                   /note="Short neurotoxin 2"
FT                   /evidence="ECO:0000269|PubMed:2719639"
FT                   /id="PRO_0000093572"
FT   DISULFID        3..21
FT                   /evidence="ECO:0000250|UniProtKB:P01467"
FT   DISULFID        15..39
FT                   /evidence="ECO:0000250|UniProtKB:P01467"
FT   DISULFID        43..49
FT                   /evidence="ECO:0000250|UniProtKB:P01467"
FT   DISULFID        50..55
FT                   /evidence="ECO:0000250|UniProtKB:P01467"
SQ   SEQUENCE   63 AA;  6847 MW;  34745A8590435C3E CRC64;
     LKCHKAQFPN IETQCKWQTL CFQRDVKPHP SSMIVLRGCT SSCGKGAMCC ATDLCNGPST
     PST