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HMRA1_YEAST
ID   HMRA1_YEAST             Reviewed;         126 AA.
AC   P0CY11; D6VR98; P01366; P09091; Q06724;
DT   28-JUN-2011, integrated into UniProtKB/Swiss-Prot.
DT   28-JUN-2011, sequence version 1.
DT   03-AUG-2022, entry version 66.
DE   RecName: Full=Silenced mating-type protein A1;
DE            Short=MATa1 protein;
GN   Name=HMRA1; OrderedLocusNames=YCR097W; ORFNames=YCR97W;
OS   Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX   NCBI_TaxID=559292;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=1574927; DOI=10.1002/yea.320080307;
RA   Sor F., Cheret G., Fabre F., Faye G., Fukuhara H.;
RT   "Sequence of the HMR region on chromosome III of Saccharomyces
RT   cerevisiae.";
RL   Yeast 8:215-222(1992).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 204508 / S288c;
RX   PubMed=1574125; DOI=10.1038/357038a0;
RA   Oliver S.G., van der Aart Q.J.M., Agostoni-Carbone M.L., Aigle M.,
RA   Alberghina L., Alexandraki D., Antoine G., Anwar R., Ballesta J.P.G.,
RA   Benit P., Berben G., Bergantino E., Biteau N., Bolle P.-A.,
RA   Bolotin-Fukuhara M., Brown A., Brown A.J.P., Buhler J.-M., Carcano C.,
RA   Carignani G., Cederberg H., Chanet R., Contreras R., Crouzet M.,
RA   Daignan-Fornier B., Defoor E., Delgado M.D., Demolder J., Doira C.,
RA   Dubois E., Dujon B., Duesterhoeft A., Erdmann D., Esteban M., Fabre F.,
RA   Fairhead C., Faye G., Feldmann H., Fiers W., Francingues-Gaillard M.-C.,
RA   Franco L., Frontali L., Fukuhara H., Fuller L.J., Galland P., Gent M.E.,
RA   Gigot D., Gilliquet V., Glansdorff N., Goffeau A., Grenson M., Grisanti P.,
RA   Grivell L.A., de Haan M., Haasemann M., Hatat D., Hoenicka J.,
RA   Hegemann J.H., Herbert C.J., Hilger F., Hohmann S., Hollenberg C.P.,
RA   Huse K., Iborra F., Indge K.J., Isono K., Jacq C., Jacquet M., James C.M.,
RA   Jauniaux J.-C., Jia Y., Jimenez A., Kelly A., Kleinhans U., Kreisl P.,
RA   Lanfranchi G., Lewis C., van der Linden C.G., Lucchini G.,
RA   Lutzenkirchen K., Maat M.J., Mallet L., Mannhaupt G., Martegani E.,
RA   Mathieu A., Maurer C.T.C., McConnell D., McKee R.A., Messenguy F.,
RA   Mewes H.-W., Molemans F., Montague M.A., Muzi Falconi M., Navas L.,
RA   Newlon C.S., Noone D., Pallier C., Panzeri L., Pearson B.M., Perea J.,
RA   Philippsen P., Pierard A., Planta R.J., Plevani P., Poetsch B., Pohl F.M.,
RA   Purnelle B., Ramezani Rad M., Rasmussen S.W., Raynal A., Remacha M.A.,
RA   Richterich P., Roberts A.B., Rodriguez F., Sanz E.,
RA   Schaaff-Gerstenschlaeger I., Scherens B., Schweitzer B., Shu Y., Skala J.,
RA   Slonimski P.P., Sor F., Soustelle C., Spiegelberg R., Stateva L.I.,
RA   Steensma H.Y., Steiner S., Thierry A., Thireos G., Tzermia M.,
RA   Urrestarazu L.A., Valle G., Vetter I., van Vliet-Reedijk J.C., Voet M.,
RA   Volckaert G., Vreken P., Wang H., Warmington J.R., von Wettstein D.,
RA   Wicksteed B.L., Wilson C., Wurst H., Xu G., Yoshikawa A., Zimmermann F.K.,
RA   Sgouros J.G.;
RT   "The complete DNA sequence of yeast chromosome III.";
RL   Nature 357:38-46(1992).
RN   [3]
RP   GENOME REANNOTATION.
RC   STRAIN=ATCC 204508 / S288c;
RX   PubMed=24374639; DOI=10.1534/g3.113.008995;
RA   Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA   Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA   Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.;
RT   "The reference genome sequence of Saccharomyces cerevisiae: Then and now.";
RL   G3 (Bethesda) 4:389-398(2014).
CC   -!- FUNCTION: Mating type proteins are sequence specific DNA-binding
CC       proteins that act as master switches in yeast differentiation by
CC       controlling gene expression in a cell type-specific fashion. Silenced
CC       copy of A1 at HMR.
CC   -!- SUBCELLULAR LOCATION: Nucleus.
CC   -!- MISCELLANEOUS: There are three genetic loci for mating type genes in
CC       S.cerevisiae. MAT is the expression locus that determines the mating
CC       type of the cell, whereas HML (containing HMLALPHA1 and HMLALPHA2) and
CC       HMR (containing HMRA1 and HMRA2) represent silenced repositories of
CC       mating type information. The mating type is determined by the MAT
CC       locus, which contains either a copy of HML or of HMR. Diploid cells are
CC       usually heterozygous for the MAT locus.
CC   -!- SIMILARITY: Belongs to the MATA1 family. {ECO:0000305}.
CC   -!- CAUTION: There is no sequence for the expressed copy of A1 in strain
CC       S288c, because this strain is of mating type alpha. A sequence for the
CC       expressed copy of A1 can be found in other strains (AC P0CY10).
CC       {ECO:0000305}.
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DR   EMBL; X59720; CAA42252.1; -; Genomic_DNA.
DR   EMBL; BK006937; DAA07567.1; -; Genomic_DNA.
DR   PIR; A90983; JEBY1.
DR   RefSeq; NP_010021.1; NM_001178804.1.
DR   PDB; 1MH3; X-ray; 2.10 A; A=71-126.
DR   PDB; 1MH4; X-ray; 2.30 A; A=71-126.
DR   PDBsum; 1MH3; -.
DR   PDBsum; 1MH4; -.
DR   AlphaFoldDB; P0CY11; -.
DR   BMRB; P0CY11; -.
DR   SMR; P0CY11; -.
DR   BioGRID; 31069; 28.
DR   ComplexPortal; CPX-684; Mating-type MATalpha2-MATa1 complex.
DR   DIP; DIP-2209N; -.
DR   IntAct; P0CY11; 1.
DR   STRING; 4932.YCR097W; -.
DR   PaxDb; P0CY11; -.
DR   EnsemblFungi; YCR097W_mRNA; YCR097W; YCR097W.
DR   GeneID; 850459; -.
DR   KEGG; sce:YCR097W; -.
DR   SGD; S000000694; HMRA1.
DR   VEuPathDB; FungiDB:YCR097W; -.
DR   eggNOG; ENOG502SCEX; Eukaryota.
DR   HOGENOM; CLU_158788_0_0_1; -.
DR   InParanoid; P0CY11; -.
DR   BioCyc; YEAST:G3O-29391-MON; -.
DR   PRO; PR:P0CY11; -.
DR   Proteomes; UP000002311; Chromosome III.
DR   RNAct; P0CY11; protein.
DR   GO; GO:0005634; C:nucleus; IDA:SGD.
DR   GO; GO:0090571; C:RNA polymerase II transcription repressor complex; IDA:ComplexPortal.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR   GO; GO:0003714; F:transcription corepressor activity; IDA:SGD.
DR   GO; GO:0007532; P:regulation of mating-type specific transcription, DNA-templated; IDA:SGD.
DR   CDD; cd00086; homeodomain; 1.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR017970; Homeobox_CS.
DR   InterPro; IPR001356; Homeobox_dom.
DR   Pfam; PF00046; Homeodomain; 1.
DR   SMART; SM00389; HOX; 1.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   PROSITE; PS00027; HOMEOBOX_1; 1.
DR   PROSITE; PS50071; HOMEOBOX_2; 1.
PE   1: Evidence at protein level;
KW   3D-structure; DNA-binding; Homeobox; Nucleus; Reference proteome;
KW   Transcription; Transcription regulation.
FT   CHAIN           1..126
FT                   /note="Silenced mating-type protein A1"
FT                   /id="PRO_0000410465"
FT   DNA_BIND        70..126
FT                   /note="Homeobox"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT   HELIX           79..91
FT                   /evidence="ECO:0007829|PDB:1MH3"
FT   HELIX           97..107
FT                   /evidence="ECO:0007829|PDB:1MH3"
FT   HELIX           111..122
FT                   /evidence="ECO:0007829|PDB:1MH3"
SQ   SEQUENCE   126 AA;  14803 MW;  B413D0042EB97B3A CRC64;
     MDDICSMAEN INRTLFNILG TEIDEINLNT NNLYNFIMES NLTKVEQHTL HKNISNNRLE
     IYHHIKKEKS PKGKSSISPQ ARAFLEQVFR RKQSLNSKEK EEVAKKCGIT PLQVRVWFIN
     KRMRSK
 
 
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