HMRM_HAEIN
ID HMRM_HAEIN Reviewed; 464 AA.
AC P45272;
DT 01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1995, sequence version 1.
DT 03-AUG-2022, entry version 129.
DE RecName: Full=Multidrug resistance protein HmrM;
DE AltName: Full=Multidrug-efflux transporter;
DE AltName: Full=Na(+)/drug antiporter;
GN Name=hmrM; Synonyms=norM; OrderedLocusNames=HI_1612;
OS Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Pasteurellales;
OC Pasteurellaceae; Haemophilus.
OX NCBI_TaxID=71421;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 51907 / DSM 11121 / KW20 / Rd;
RX PubMed=7542800; DOI=10.1126/science.7542800;
RA Fleischmann R.D., Adams M.D., White O., Clayton R.A., Kirkness E.F.,
RA Kerlavage A.R., Bult C.J., Tomb J.-F., Dougherty B.A., Merrick J.M.,
RA McKenney K., Sutton G.G., FitzHugh W., Fields C.A., Gocayne J.D.,
RA Scott J.D., Shirley R., Liu L.-I., Glodek A., Kelley J.M., Weidman J.F.,
RA Phillips C.A., Spriggs T., Hedblom E., Cotton M.D., Utterback T.R.,
RA Hanna M.C., Nguyen D.T., Saudek D.M., Brandon R.C., Fine L.D.,
RA Fritchman J.L., Fuhrmann J.L., Geoghagen N.S.M., Gnehm C.L., McDonald L.A.,
RA Small K.V., Fraser C.M., Smith H.O., Venter J.C.;
RT "Whole-genome random sequencing and assembly of Haemophilus influenzae
RT Rd.";
RL Science 269:496-512(1995).
RN [2]
RP FUNCTION.
RC STRAIN=ATCC 51907 / DSM 11121 / KW20 / Rd;
RX PubMed=14695443; DOI=10.1111/j.1348-0421.2003.tb03467.x;
RA Xu X.-J., Su X.-Z., Morita Y., Kuroda T., Mizushima T., Tsuchiya T.;
RT "Molecular cloning and characterization of the HmrM multidrug efflux pump
RT from Haemophilus influenzae Rd.";
RL Microbiol. Immunol. 47:937-943(2003).
CC -!- FUNCTION: Multidrug efflux pump that functions as a Na(+)/drug
CC antiporter. Confers resistance to norfloxacin, acriflavine,
CC doxorubicin, ethidium bromide, tetraphenylphosphonium chloride,
CC daunomycin, berberine and sodium deoxycholate.
CC {ECO:0000269|PubMed:14695443}.
CC -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000250}; Multi-pass
CC membrane protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the multi antimicrobial extrusion (MATE) (TC
CC 2.A.66.1) family. {ECO:0000305}.
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DR EMBL; L42023; AAC23256.1; -; Genomic_DNA.
DR PIR; B64173; B64173.
DR RefSeq; NP_439754.1; NC_000907.1.
DR RefSeq; WP_005693623.1; NC_000907.1.
DR AlphaFoldDB; P45272; -.
DR SMR; P45272; -.
DR STRING; 71421.HI_1612; -.
DR DNASU; 950466; -.
DR EnsemblBacteria; AAC23256; AAC23256; HI_1612.
DR KEGG; hin:HI_1612; -.
DR PATRIC; fig|71421.8.peg.1685; -.
DR eggNOG; COG0534; Bacteria.
DR HOGENOM; CLU_012893_6_0_6; -.
DR OMA; EFWILLK; -.
DR PhylomeDB; P45272; -.
DR BioCyc; HINF71421:G1GJ1-1625-MON; -.
DR Proteomes; UP000000579; Chromosome.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; IBA:GO_Central.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015297; F:antiporter activity; IEA:UniProtKB-KW.
DR GO; GO:0022857; F:transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0042910; F:xenobiotic transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0046677; P:response to antibiotic; IBA:GO_Central.
DR GO; GO:0006814; P:sodium ion transport; IEA:UniProtKB-KW.
DR InterPro; IPR002528; MATE_fam.
DR Pfam; PF01554; MatE; 2.
DR PIRSF; PIRSF006603; DinF; 1.
DR TIGRFAMs; TIGR00797; matE; 1.
PE 3: Inferred from homology;
KW Antibiotic resistance; Antiport; Cell inner membrane; Cell membrane;
KW Ion transport; Membrane; Reference proteome; Sodium; Sodium transport;
KW Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..464
FT /note="Multidrug resistance protein HmrM"
FT /id="PRO_0000164219"
FT TRANSMEM 16..36
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 51..71
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 96..116
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 134..154
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 164..184
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 194..214
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 248..268
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 288..308
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 321..341
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 348..368
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 391..411
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 423..443
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 464 AA; 51307 MW; 55E8CBA13CB4DB23 CRC64;
MNFRLLSQYH ADIKKLIKIS LPILLAQIAQ NSMGLADTIM AGRVSSTDMA AISIGASIWM
PLMFFGQGLL LALPPTISYL NGSGQHHRIA HQVRQGIWLV LGVSIPLGLL IYFCEIPLQY
MQMESKMSDL ARDYLHAMLW GLPAYLMLIN FRCLNDGIEK TKPAMVITFL GLLINIPLNY
IFIYGKFGMP AFGAVGCGIA TAIVNWAMCL MMIFYSYTNT QERSLKVFSQ LIEMPNPKTL
KKLLRLGLPI AIAICCEVAL YALTSLMLSP LGATIVASHQ ITLNTSSFIF MFPMSIGMAT
TILVGQALGA GSPQNAKKIG YAALLLGLTV TIVTALITIF FRYEIASIFV TDEIVIAMAA
NLLLFAALYQ FSDTIQMVVG GILRGYKDTK VILYITLFSY WVIGVPLGYT LGRTDWLVPH
IDAKGFWIAF VVSLTFAAFL LSLRMKKMQA MNDNAILQRL EKLK
