ID   HMRR1_RHIME             Reviewed;         147 AA.
AC   P58378;
DT   16-NOV-2001, integrated into UniProtKB/Swiss-Prot.
DT   16-NOV-2001, sequence version 1.
DT   25-MAY-2022, entry version 115.
DE   RecName: Full=Heavy metal-dependent transcription regulator 1;
GN   Name=hmrR1; Synonyms=hmrR; OrderedLocusNames=RA0549; ORFNames=SMa1014;
OS   Rhizobium meliloti (strain 1021) (Ensifer meliloti) (Sinorhizobium
OS   meliloti).
OG   Plasmid pSymA (megaplasmid 1).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Hyphomicrobiales;
OC   Rhizobiaceae; Sinorhizobium/Ensifer group; Sinorhizobium.
OX   NCBI_TaxID=266834;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=1021;
RX   PubMed=11481432; DOI=10.1073/pnas.161294798;
RA   Barnett M.J., Fisher R.F., Jones T., Komp C., Abola A.P., Barloy-Hubler F.,
RA   Bowser L., Capela D., Galibert F., Gouzy J., Gurjal M., Hong A., Huizar L.,
RA   Hyman R.W., Kahn D., Kahn M.L., Kalman S., Keating D.H., Palm C.,
RA   Peck M.C., Surzycki R., Wells D.H., Yeh K.-C., Davis R.W., Federspiel N.A.,
RA   Long S.R.;
RT   "Nucleotide sequence and predicted functions of the entire Sinorhizobium
RT   meliloti pSymA megaplasmid.";
RL   Proc. Natl. Acad. Sci. U.S.A. 98:9883-9888(2001).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=1021;
RX   PubMed=11474104; DOI=10.1126/science.1060966;
RA   Galibert F., Finan T.M., Long S.R., Puehler A., Abola P., Ampe F.,
RA   Barloy-Hubler F., Barnett M.J., Becker A., Boistard P., Bothe G.,
RA   Boutry M., Bowser L., Buhrmester J., Cadieu E., Capela D., Chain P.,
RA   Cowie A., Davis R.W., Dreano S., Federspiel N.A., Fisher R.F., Gloux S.,
RA   Godrie T., Goffeau A., Golding B., Gouzy J., Gurjal M., Hernandez-Lucas I.,
RA   Hong A., Huizar L., Hyman R.W., Jones T., Kahn D., Kahn M.L., Kalman S.,
RA   Keating D.H., Kiss E., Komp C., Lelaure V., Masuy D., Palm C., Peck M.C.,
RA   Pohl T.M., Portetelle D., Purnelle B., Ramsperger U., Surzycki R.,
RA   Thebault P., Vandenbol M., Vorhoelter F.J., Weidner S., Wells D.H.,
RA   Wong K., Yeh K.-C., Batut J.;
RT   "The composite genome of the legume symbiont Sinorhizobium meliloti.";
RL   Science 293:668-672(2001).
CC   -!- FUNCTION: Transcriptional regulator involved in acid tolerance. Binds
CC       copper (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}.
CC   -!- DOMAIN: It contains a N-terminal DNA binding region and a C-terminal
CC       metal binding region. {ECO:0000250}.
CC   -!- CAUTION: We have changed a potential AGG for Arg-1 as ATG for Met-1.
CC       {ECO:0000305}.
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DR   EMBL; AE006469; AAK65207.1; ALT_SEQ; Genomic_DNA.
DR   PIR; E95330; E95330.
DR   RefSeq; NP_435795.1; NC_003037.1.
DR   AlphaFoldDB; P58378; -.
DR   SMR; P58378; -.
DR   EnsemblBacteria; AAK65207; AAK65207; SMa1014.
DR   KEGG; sme:SMa1014; -.
DR   PATRIC; fig|266834.11.peg.565; -.
DR   HOGENOM; CLU_060077_2_0_5; -.
DR   Proteomes; UP000001976; Plasmid pSymA.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005507; F:copper ion binding; IEA:InterPro.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR   GO; GO:0045893; P:positive regulation of transcription, DNA-templated; IEA:InterPro.
DR   CDD; cd01108; HTH_CueR; 1.
DR   InterPro; IPR011789; CueR.
DR   InterPro; IPR009061; DNA-bd_dom_put_sf.
DR   InterPro; IPR000551; MerR-type_HTH_dom.
DR   InterPro; IPR015358; Tscrpt_reg_MerR_DNA-bd.
DR   Pfam; PF00376; MerR; 1.
DR   Pfam; PF09278; MerR-DNA-bind; 1.
DR   PRINTS; PR00040; HTHMERR.
DR   SMART; SM00422; HTH_MERR; 1.
DR   SUPFAM; SSF46955; SSF46955; 1.
DR   TIGRFAMs; TIGR02044; CueR; 1.
DR   PROSITE; PS50937; HTH_MERR_2; 1.
PE   3: Inferred from homology;
KW   Copper; Cytoplasm; DNA-binding; Plasmid; Reference proteome; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..147
FT                   /note="Heavy metal-dependent transcription regulator 1"
FT                   /id="PRO_0000098124"
FT   DOMAIN          1..70
FT                   /note="HTH merR-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00254"
FT   DNA_BIND        3..22
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00254"
SQ   SEQUENCE   147 AA;  16415 MW;  3A447536A9C07A86 CRC64;
     MNIGQASKVV SGVSSKMIRY YEQIGLIRPA LRTASSYRVY GDNDIHTLQF VRRARDLGFS
     VEQIKDLLAL WRDRSRNSAN VKAVALEHIA ELERKIAAIE EMTTTLKHLA SHCHGDDRPE
     CPIIEEIANA ADGKKPRANA RFGLSAL