HMS2_YEAST
ID HMS2_YEAST Reviewed; 358 AA.
AC P47175; D6VWW5;
DT 01-FEB-1996, integrated into UniProtKB/Swiss-Prot.
DT 01-FEB-1996, sequence version 1.
DT 03-AUG-2022, entry version 144.
DE RecName: Full=Probable transcription factor HMS2;
DE AltName: Full=High-copy MEP suppressor 2;
GN Name=HMS2; OrderedLocusNames=YJR147W; ORFNames=J2204;
OS Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX NCBI_TaxID=559292;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=8641269; DOI=10.1002/j.1460-2075.1996.tb00557.x;
RA Galibert F., Alexandraki D., Baur A., Boles E., Chalwatzis N., Chuat J.-C.,
RA Coster F., Cziepluch C., de Haan M., Domdey H., Durand P., Entian K.-D.,
RA Gatius M., Goffeau A., Grivell L.A., Hennemann A., Herbert C.J.,
RA Heumann K., Hilger F., Hollenberg C.P., Huang M.-E., Jacq C.,
RA Jauniaux J.-C., Katsoulou C., Kirchrath L., Kleine K., Kordes E.,
RA Koetter P., Liebl S., Louis E.J., Manus V., Mewes H.-W., Miosga T.,
RA Obermaier B., Perea J., Pohl T.M., Portetelle D., Pujol A., Purnelle B.,
RA Ramezani Rad M., Rasmussen S.W., Rose M., Rossau R.,
RA Schaaff-Gerstenschlaeger I., Smits P.H.M., Scarcez T., Soriano N.,
RA To Van D., Tzermia M., Van Broekhoven A., Vandenbol M., Wedler H.,
RA von Wettstein D., Wambutt R., Zagulski M., Zollner A., Karpfinger-Hartl L.;
RT "Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X.";
RL EMBO J. 15:2031-2049(1996).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=24374639; DOI=10.1534/g3.113.008995;
RA Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.;
RT "The reference genome sequence of Saccharomyces cerevisiae: Then and now.";
RL G3 (Bethesda) 4:389-398(2014).
RN [3]
RP FUNCTION.
RX PubMed=9832522; DOI=10.1093/genetics/150.4.1443;
RA Lorenz M.C., Heitman J.;
RT "Regulators of pseudohyphal differentiation in Saccharomyces cerevisiae
RT identified through multicopy suppressor analysis in ammonium permease
RT mutant strains.";
RL Genetics 150:1443-1457(1998).
RN [4]
RP SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
RX PubMed=14562095; DOI=10.1038/nature02026;
RA Huh W.-K., Falvo J.V., Gerke L.C., Carroll A.S., Howson R.W.,
RA Weissman J.S., O'Shea E.K.;
RT "Global analysis of protein localization in budding yeast.";
RL Nature 425:686-691(2003).
RN [5]
RP LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
RX PubMed=14562106; DOI=10.1038/nature02046;
RA Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N.,
RA O'Shea E.K., Weissman J.S.;
RT "Global analysis of protein expression in yeast.";
RL Nature 425:737-741(2003).
CC -!- FUNCTION: Involved in pseudohyphal differentiation.
CC {ECO:0000269|PubMed:9832522}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:14562095}. Nucleus
CC {ECO:0000269|PubMed:14562095}.
CC -!- MISCELLANEOUS: Present with 2050 molecules/cell in log phase SD medium.
CC {ECO:0000269|PubMed:14562106}.
CC -!- SIMILARITY: Belongs to the HSF family. {ECO:0000305}.
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DR EMBL; Z49646; CAA89680.1; -; Genomic_DNA.
DR EMBL; BK006943; DAA08931.1; -; Genomic_DNA.
DR PIR; S57176; S57176.
DR RefSeq; NP_012681.1; NM_001181805.1.
DR AlphaFoldDB; P47175; -.
DR SMR; P47175; -.
DR BioGRID; 33902; 119.
DR STRING; 4932.YJR147W; -.
DR iPTMnet; P47175; -.
DR MaxQB; P47175; -.
DR PaxDb; P47175; -.
DR PRIDE; P47175; -.
DR EnsemblFungi; YJR147W_mRNA; YJR147W; YJR147W.
DR GeneID; 853612; -.
DR KEGG; sce:YJR147W; -.
DR SGD; S000003908; HMS2.
DR VEuPathDB; FungiDB:YJR147W; -.
DR eggNOG; KOG0627; Eukaryota.
DR GeneTree; ENSGT00940000169930; -.
DR HOGENOM; CLU_787906_0_0_1; -.
DR InParanoid; P47175; -.
DR OMA; QWHPQLH; -.
DR BioCyc; YEAST:G3O-31761-MON; -.
DR PRO; PR:P47175; -.
DR Proteomes; UP000002311; Chromosome X.
DR RNAct; P47175; protein.
DR GO; GO:0005737; C:cytoplasm; HDA:SGD.
DR GO; GO:0005634; C:nucleus; HDA:SGD.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IBA:GO_Central.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0007124; P:pseudohyphal growth; IGI:SGD.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR Gene3D; 1.10.10.10; -; 1.
DR InterPro; IPR000232; HSF_DNA-bd.
DR InterPro; IPR027725; HSF_fam.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR10015; PTHR10015; 1.
DR Pfam; PF00447; HSF_DNA-bind; 1.
DR PRINTS; PR00056; HSFDOMAIN.
DR SMART; SM00415; HSF; 1.
DR SUPFAM; SSF46785; SSF46785; 1.
PE 1: Evidence at protein level;
KW Cytoplasm; DNA-binding; Nucleus; Reference proteome.
FT CHAIN 1..358
FT /note="Probable transcription factor HMS2"
FT /id="PRO_0000124596"
FT DNA_BIND 12..116
FT /evidence="ECO:0000250"
SQ SEQUENCE 358 AA; 41192 MW; E2964157FC952D42 CRC64;
MDATSRMEQP DVFVSKLYHL LQGNAYSNII QWSTDGSKLV IWNPDQFTKV ILERFFGIHT
FAAFVKQLSK YNFQKAGRPD CVEFSNIHFQ KDNINSLSLV KAHQSAATPN VAAVNNMNKQ
CTFHWDPFKV NSILSKAIGK PSFEKLVKNV DRLQGNLDEL KSTNADSLRI IREINASLQT
ISYHQFHAYQ TANFLQENFE AIKKVVCPDS CLQHQQRQPK RPKRYSLLLL IPNASELSET
PLMRFAGVFE FMNCSLDTAT QWHPQLHPEA YDLLFVTVSP NMQQEHLIYF KRLRNLLPSF
PVIAIINRPV SPQDTSIAPS NYSRYYFHHF LQLGFSDILV SPFTPTQLIT LLSKHLRT