3SOII_BUNFA
ID 3SOII_BUNFA Reviewed; 79 AA.
AC P0C553;
DT 10-JUL-2007, integrated into UniProtKB/Swiss-Prot.
DT 10-JUL-2007, sequence version 1.
DT 25-MAY-2022, entry version 44.
DE RecName: Full=Neurotoxin 3FTx-LI;
DE Flags: Precursor;
OS Bungarus fasciatus (Banded krait) (Pseudoboa fasciata).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera;
OC Serpentes; Colubroidea; Elapidae; Bungarinae; Bungarus.
OX NCBI_TaxID=8613;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 22-35, AND MASS
RP SPECTROMETRY.
RC TISSUE=Venom, and Venom gland;
RX PubMed=17166178; DOI=10.1111/j.1742-4658.2006.05598.x;
RA Tsai I.-H., Tsai H.-Y., Saha A., Gomes A.;
RT "Sequences, geographic variations and molecular phylogeny of venom
RT phospholipases and three-finger toxins of eastern India Bungarus fasciatus
RT and kinetic analyses of its Pro31 phospholipases A2.";
RL FEBS J. 274:512-525(2007).
CC -!- FUNCTION: Blocks both the muscle-twitch response to nerve stimulation
CC and the response to exogenous acetylcholine. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Secreted.
CC -!- TISSUE SPECIFICITY: Expressed by the venom gland.
CC -!- MASS SPECTROMETRY: Mass=6455; Mass_error=1; Method=Electrospray;
CC Evidence={ECO:0000269|PubMed:17166178};
CC -!- SIMILARITY: Belongs to the snake three-finger toxin family. Short-chain
CC subfamily. Orphan group XVIII sub-subfamily. {ECO:0000305}.
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DR EMBL; DQ508408; -; NOT_ANNOTATED_CDS; mRNA.
DR AlphaFoldDB; P0C553; -.
DR SMR; P0C553; -.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR Gene3D; 2.10.60.10; -; 1.
DR InterPro; IPR045860; Snake_toxin-like_sf.
DR SUPFAM; SSF57302; SSF57302; 1.
PE 1: Evidence at protein level;
KW Direct protein sequencing; Disulfide bond; Neurotoxin;
KW Postsynaptic neurotoxin; Secreted; Signal; Toxin.
FT SIGNAL 1..21
FT /evidence="ECO:0000269|PubMed:17166178"
FT CHAIN 22..79
FT /note="Neurotoxin 3FTx-LI"
FT /evidence="ECO:0000305|PubMed:17166178"
FT /id="PRO_0000293105"
FT DISULFID 24..43
FT /evidence="ECO:0000250|UniProtKB:P60301"
FT DISULFID 36..61
FT /evidence="ECO:0000250|UniProtKB:P60301"
FT DISULFID 65..71
FT /evidence="ECO:0000250|UniProtKB:P60301"
FT DISULFID 72..77
FT /evidence="ECO:0000250|UniProtKB:P60301"
SQ SEQUENCE 79 AA; 8754 MW; 12509BAEED38DEE3 CRC64;
MKTLLLTLVV VTIVCLDLGY TLICYSSSMN KDSKTCQKWE TVCFQEAFKP HSSGMIILRG
CASSCPKGYT CCATDLCNW