HMUR_YERPE
ID HMUR_YERPE Reviewed; 676 AA.
AC Q56989; Q0WK23;
DT 01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1997, sequence version 1.
DT 25-MAY-2022, entry version 143.
DE RecName: Full=Hemin receptor;
DE Flags: Precursor;
GN Name=hmuR; OrderedLocusNames=YPO0283, y0543, YP_0438;
OS Yersinia pestis.
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Yersiniaceae; Yersinia.
OX NCBI_TaxID=632;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=KIM6;
RX PubMed=9026634; DOI=10.1111/j.1365-2958.1996.tb02512.x;
RA Hornung J.M., Jones H.A., Perry R.D.;
RT "The hmu locus of Yersinia pestis is essential for utilization of free
RT haemin and haem-protein complexes as iron sources.";
RL Mol. Microbiol. 20:725-739(1996).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CO-92 / Biovar Orientalis;
RX PubMed=11586360; DOI=10.1038/35097083;
RA Parkhill J., Wren B.W., Thomson N.R., Titball R.W., Holden M.T.G.,
RA Prentice M.B., Sebaihia M., James K.D., Churcher C.M., Mungall K.L.,
RA Baker S., Basham D., Bentley S.D., Brooks K., Cerdeno-Tarraga A.-M.,
RA Chillingworth T., Cronin A., Davies R.M., Davis P., Dougan G., Feltwell T.,
RA Hamlin N., Holroyd S., Jagels K., Karlyshev A.V., Leather S., Moule S.,
RA Oyston P.C.F., Quail M.A., Rutherford K.M., Simmonds M., Skelton J.,
RA Stevens K., Whitehead S., Barrell B.G.;
RT "Genome sequence of Yersinia pestis, the causative agent of plague.";
RL Nature 413:523-527(2001).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=KIM10+ / Biovar Mediaevalis;
RX PubMed=12142430; DOI=10.1128/jb.184.16.4601-4611.2002;
RA Deng W., Burland V., Plunkett G. III, Boutin A., Mayhew G.F., Liss P.,
RA Perna N.T., Rose D.J., Mau B., Zhou S., Schwartz D.C., Fetherston J.D.,
RA Lindler L.E., Brubaker R.R., Plano G.V., Straley S.C., McDonough K.A.,
RA Nilles M.L., Matson J.S., Blattner F.R., Perry R.D.;
RT "Genome sequence of Yersinia pestis KIM.";
RL J. Bacteriol. 184:4601-4611(2002).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=91001 / Biovar Mediaevalis;
RX PubMed=15368893; DOI=10.1093/dnares/11.3.179;
RA Song Y., Tong Z., Wang J., Wang L., Guo Z., Han Y., Zhang J., Pei D.,
RA Zhou D., Qin H., Pang X., Han Y., Zhai J., Li M., Cui B., Qi Z., Jin L.,
RA Dai R., Chen F., Li S., Ye C., Du Z., Lin W., Wang J., Yu J., Yang H.,
RA Wang J., Huang P., Yang R.;
RT "Complete genome sequence of Yersinia pestis strain 91001, an isolate
RT avirulent to humans.";
RL DNA Res. 11:179-197(2004).
CC -!- FUNCTION: This protein is involved in the initial step of iron uptake
CC by binding hemin, an iron chelatin siderophore that allows the bacteria
CC to extract iron from the environment.
CC -!- SUBCELLULAR LOCATION: Cell outer membrane.
CC -!- SIMILARITY: Belongs to the TonB-dependent receptor family.
CC {ECO:0000305}.
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DR EMBL; U60647; AAC64866.1; -; Genomic_DNA.
DR EMBL; AL590842; CAL18969.1; -; Genomic_DNA.
DR EMBL; AE009952; AAM84131.1; -; Genomic_DNA.
DR EMBL; AE017042; AAS60709.1; -; Genomic_DNA.
DR PIR; AG0035; AG0035.
DR PIR; T12069; T12069.
DR RefSeq; WP_002209062.1; NZ_WUCM01000046.1.
DR RefSeq; YP_002345365.1; NC_003143.1.
DR AlphaFoldDB; Q56989; -.
DR SMR; Q56989; -.
DR IntAct; Q56989; 2.
DR STRING; 214092.YPO0283; -.
DR PaxDb; Q56989; -.
DR PRIDE; Q56989; -.
DR DNASU; 1145490; -.
DR EnsemblBacteria; AAM84131; AAM84131; y0543.
DR EnsemblBacteria; AAS60709; AAS60709; YP_0438.
DR GeneID; 57974318; -.
DR KEGG; ype:YPO0283; -.
DR KEGG; ypk:y0543; -.
DR KEGG; ypm:YP_0438; -.
DR PATRIC; fig|214092.21.peg.516; -.
DR eggNOG; COG4771; Bacteria.
DR HOGENOM; CLU_008287_19_3_6; -.
DR OMA; QYARGFR; -.
DR Proteomes; UP000000815; Chromosome.
DR Proteomes; UP000001019; Chromosome.
DR Proteomes; UP000002490; Chromosome.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0031230; C:intrinsic component of cell outer membrane; IBA:GO_Central.
DR GO; GO:0015232; F:heme transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0015344; F:siderophore uptake transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0071281; P:cellular response to iron ion; EXP:CollecTF.
DR GO; GO:0055072; P:iron ion homeostasis; IEA:UniProtKB-KW.
DR GO; GO:0044718; P:siderophore transmembrane transport; IBA:GO_Central.
DR Gene3D; 2.170.130.10; -; 1.
DR Gene3D; 2.40.170.20; -; 1.
DR InterPro; IPR039426; BtuB-like.
DR InterPro; IPR012910; Plug_dom.
DR InterPro; IPR037066; Plug_dom_sf.
DR InterPro; IPR000531; TonB-dep_rcpt_b-brl.
DR InterPro; IPR010916; TonB_box_CS.
DR InterPro; IPR011276; TonB_haem/Hb_rcpt.
DR InterPro; IPR010949; TonB_Hb/transfer/lactofer_rcpt.
DR InterPro; IPR036942; TonB_rcpt_b-brl_sf.
DR PANTHER; PTHR30069; PTHR30069; 1.
DR Pfam; PF07715; Plug; 1.
DR Pfam; PF00593; TonB_dep_Rec; 1.
DR TIGRFAMs; TIGR01785; TonB-hemin; 1.
DR TIGRFAMs; TIGR01786; TonB-hemlactrns; 1.
DR PROSITE; PS00430; TONB_DEPENDENT_REC_1; 1.
PE 3: Inferred from homology;
KW Cell outer membrane; Ion transport; Iron; Iron transport; Membrane;
KW Receptor; Reference proteome; Signal; TonB box; Transmembrane;
KW Transmembrane beta strand; Transport.
FT SIGNAL 1..28
FT /evidence="ECO:0000255"
FT CHAIN 29..676
FT /note="Hemin receptor"
FT /id="PRO_0000034759"
FT MOTIF 44..51
FT /note="TonB box"
FT MOTIF 659..676
FT /note="TonB C-terminal box"
SQ SEQUENCE 676 AA; 74230 MW; 84ED731CB914ACD3 CRC64;
MLRSTSDRFR WSSLSLAIAC TLPLATQAAD TTTTQTSSKK HSTDTMVVTA TGNERSSFEA
PMMVTVIEGN APTSQTAATA ADMLRQVPGL TVTGSGRTNG QDVVMRGYGK QGVLTLVDGV
RQGTDTGHLN STFLDPALVK RIEIVRGPAA LLYGSGALGG VIAYETVDAA DMLQPGQNSG
YRVYSSAATG DHSFGLGASA FGRTDDLDGI LSFGTRDIGN IRQSNGFNAP NDETISNVLA
KGTWQIDSIQ SLSANLRYYN NSAIEPKNPQ TSAPSSTNVM TNRSTIQRDA QLRYNIKPLD
QEWLNATAQV YYSEVEINAR PQGSAEEGRE QTTEGVKLEN RTRLFIESPA SHLLTYGTET
YKQEQTPGGA TESFPQAKIR FSSGWLQDEI TLRDLPVSIL AGTRYDNYSG SSDGYADVDA
DKWSSRGAIS ITPTDWLMLF GSYAQAFRAP TMGEMYNDSK HFAIPIRPGL TLTNYWVPNP
NLKPETNETQ EYGFGLRFSD LLMAEDDLQF KVSYFDTKAK DYISTRVDMQ AMTTTSVNID
QAKIWGWDAS MSYKTALFNW DLAYNRTRGK NQNTDEWLDT INPDTVTSIV DVPVANSGFS
VGWIGTFANR SSRVSSSTPQ AGYGVNDFYV SYKGQEAFKG MTTTMLLGNV FEKEYYTPQG
IPQDGRNVKF FVSYQW