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HMUR_YERPE
ID   HMUR_YERPE              Reviewed;         676 AA.
AC   Q56989; Q0WK23;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1997, sequence version 1.
DT   25-MAY-2022, entry version 143.
DE   RecName: Full=Hemin receptor;
DE   Flags: Precursor;
GN   Name=hmuR; OrderedLocusNames=YPO0283, y0543, YP_0438;
OS   Yersinia pestis.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Yersiniaceae; Yersinia.
OX   NCBI_TaxID=632;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=KIM6;
RX   PubMed=9026634; DOI=10.1111/j.1365-2958.1996.tb02512.x;
RA   Hornung J.M., Jones H.A., Perry R.D.;
RT   "The hmu locus of Yersinia pestis is essential for utilization of free
RT   haemin and haem-protein complexes as iron sources.";
RL   Mol. Microbiol. 20:725-739(1996).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CO-92 / Biovar Orientalis;
RX   PubMed=11586360; DOI=10.1038/35097083;
RA   Parkhill J., Wren B.W., Thomson N.R., Titball R.W., Holden M.T.G.,
RA   Prentice M.B., Sebaihia M., James K.D., Churcher C.M., Mungall K.L.,
RA   Baker S., Basham D., Bentley S.D., Brooks K., Cerdeno-Tarraga A.-M.,
RA   Chillingworth T., Cronin A., Davies R.M., Davis P., Dougan G., Feltwell T.,
RA   Hamlin N., Holroyd S., Jagels K., Karlyshev A.V., Leather S., Moule S.,
RA   Oyston P.C.F., Quail M.A., Rutherford K.M., Simmonds M., Skelton J.,
RA   Stevens K., Whitehead S., Barrell B.G.;
RT   "Genome sequence of Yersinia pestis, the causative agent of plague.";
RL   Nature 413:523-527(2001).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=KIM10+ / Biovar Mediaevalis;
RX   PubMed=12142430; DOI=10.1128/jb.184.16.4601-4611.2002;
RA   Deng W., Burland V., Plunkett G. III, Boutin A., Mayhew G.F., Liss P.,
RA   Perna N.T., Rose D.J., Mau B., Zhou S., Schwartz D.C., Fetherston J.D.,
RA   Lindler L.E., Brubaker R.R., Plano G.V., Straley S.C., McDonough K.A.,
RA   Nilles M.L., Matson J.S., Blattner F.R., Perry R.D.;
RT   "Genome sequence of Yersinia pestis KIM.";
RL   J. Bacteriol. 184:4601-4611(2002).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=91001 / Biovar Mediaevalis;
RX   PubMed=15368893; DOI=10.1093/dnares/11.3.179;
RA   Song Y., Tong Z., Wang J., Wang L., Guo Z., Han Y., Zhang J., Pei D.,
RA   Zhou D., Qin H., Pang X., Han Y., Zhai J., Li M., Cui B., Qi Z., Jin L.,
RA   Dai R., Chen F., Li S., Ye C., Du Z., Lin W., Wang J., Yu J., Yang H.,
RA   Wang J., Huang P., Yang R.;
RT   "Complete genome sequence of Yersinia pestis strain 91001, an isolate
RT   avirulent to humans.";
RL   DNA Res. 11:179-197(2004).
CC   -!- FUNCTION: This protein is involved in the initial step of iron uptake
CC       by binding hemin, an iron chelatin siderophore that allows the bacteria
CC       to extract iron from the environment.
CC   -!- SUBCELLULAR LOCATION: Cell outer membrane.
CC   -!- SIMILARITY: Belongs to the TonB-dependent receptor family.
CC       {ECO:0000305}.
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DR   EMBL; U60647; AAC64866.1; -; Genomic_DNA.
DR   EMBL; AL590842; CAL18969.1; -; Genomic_DNA.
DR   EMBL; AE009952; AAM84131.1; -; Genomic_DNA.
DR   EMBL; AE017042; AAS60709.1; -; Genomic_DNA.
DR   PIR; AG0035; AG0035.
DR   PIR; T12069; T12069.
DR   RefSeq; WP_002209062.1; NZ_WUCM01000046.1.
DR   RefSeq; YP_002345365.1; NC_003143.1.
DR   AlphaFoldDB; Q56989; -.
DR   SMR; Q56989; -.
DR   IntAct; Q56989; 2.
DR   STRING; 214092.YPO0283; -.
DR   PaxDb; Q56989; -.
DR   PRIDE; Q56989; -.
DR   DNASU; 1145490; -.
DR   EnsemblBacteria; AAM84131; AAM84131; y0543.
DR   EnsemblBacteria; AAS60709; AAS60709; YP_0438.
DR   GeneID; 57974318; -.
DR   KEGG; ype:YPO0283; -.
DR   KEGG; ypk:y0543; -.
DR   KEGG; ypm:YP_0438; -.
DR   PATRIC; fig|214092.21.peg.516; -.
DR   eggNOG; COG4771; Bacteria.
DR   HOGENOM; CLU_008287_19_3_6; -.
DR   OMA; QYARGFR; -.
DR   Proteomes; UP000000815; Chromosome.
DR   Proteomes; UP000001019; Chromosome.
DR   Proteomes; UP000002490; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0031230; C:intrinsic component of cell outer membrane; IBA:GO_Central.
DR   GO; GO:0015232; F:heme transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0015344; F:siderophore uptake transmembrane transporter activity; IBA:GO_Central.
DR   GO; GO:0071281; P:cellular response to iron ion; EXP:CollecTF.
DR   GO; GO:0055072; P:iron ion homeostasis; IEA:UniProtKB-KW.
DR   GO; GO:0044718; P:siderophore transmembrane transport; IBA:GO_Central.
DR   Gene3D; 2.170.130.10; -; 1.
DR   Gene3D; 2.40.170.20; -; 1.
DR   InterPro; IPR039426; BtuB-like.
DR   InterPro; IPR012910; Plug_dom.
DR   InterPro; IPR037066; Plug_dom_sf.
DR   InterPro; IPR000531; TonB-dep_rcpt_b-brl.
DR   InterPro; IPR010916; TonB_box_CS.
DR   InterPro; IPR011276; TonB_haem/Hb_rcpt.
DR   InterPro; IPR010949; TonB_Hb/transfer/lactofer_rcpt.
DR   InterPro; IPR036942; TonB_rcpt_b-brl_sf.
DR   PANTHER; PTHR30069; PTHR30069; 1.
DR   Pfam; PF07715; Plug; 1.
DR   Pfam; PF00593; TonB_dep_Rec; 1.
DR   TIGRFAMs; TIGR01785; TonB-hemin; 1.
DR   TIGRFAMs; TIGR01786; TonB-hemlactrns; 1.
DR   PROSITE; PS00430; TONB_DEPENDENT_REC_1; 1.
PE   3: Inferred from homology;
KW   Cell outer membrane; Ion transport; Iron; Iron transport; Membrane;
KW   Receptor; Reference proteome; Signal; TonB box; Transmembrane;
KW   Transmembrane beta strand; Transport.
FT   SIGNAL          1..28
FT                   /evidence="ECO:0000255"
FT   CHAIN           29..676
FT                   /note="Hemin receptor"
FT                   /id="PRO_0000034759"
FT   MOTIF           44..51
FT                   /note="TonB box"
FT   MOTIF           659..676
FT                   /note="TonB C-terminal box"
SQ   SEQUENCE   676 AA;  74230 MW;  84ED731CB914ACD3 CRC64;
     MLRSTSDRFR WSSLSLAIAC TLPLATQAAD TTTTQTSSKK HSTDTMVVTA TGNERSSFEA
     PMMVTVIEGN APTSQTAATA ADMLRQVPGL TVTGSGRTNG QDVVMRGYGK QGVLTLVDGV
     RQGTDTGHLN STFLDPALVK RIEIVRGPAA LLYGSGALGG VIAYETVDAA DMLQPGQNSG
     YRVYSSAATG DHSFGLGASA FGRTDDLDGI LSFGTRDIGN IRQSNGFNAP NDETISNVLA
     KGTWQIDSIQ SLSANLRYYN NSAIEPKNPQ TSAPSSTNVM TNRSTIQRDA QLRYNIKPLD
     QEWLNATAQV YYSEVEINAR PQGSAEEGRE QTTEGVKLEN RTRLFIESPA SHLLTYGTET
     YKQEQTPGGA TESFPQAKIR FSSGWLQDEI TLRDLPVSIL AGTRYDNYSG SSDGYADVDA
     DKWSSRGAIS ITPTDWLMLF GSYAQAFRAP TMGEMYNDSK HFAIPIRPGL TLTNYWVPNP
     NLKPETNETQ EYGFGLRFSD LLMAEDDLQF KVSYFDTKAK DYISTRVDMQ AMTTTSVNID
     QAKIWGWDAS MSYKTALFNW DLAYNRTRGK NQNTDEWLDT INPDTVTSIV DVPVANSGFS
     VGWIGTFANR SSRVSSSTPQ AGYGVNDFYV SYKGQEAFKG MTTTMLLGNV FEKEYYTPQG
     IPQDGRNVKF FVSYQW
 
 
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