HMUT_YERPE
ID HMUT_YERPE Reviewed; 279 AA.
AC Q56991; Q0WK25;
DT 01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT 30-MAY-2000, sequence version 2.
DT 25-MAY-2022, entry version 145.
DE RecName: Full=Hemin-binding periplasmic protein HmuT;
DE Flags: Precursor;
GN Name=hmuT; OrderedLocusNames=YPO0281, y0541, YP_0436;
OS Yersinia pestis.
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Yersiniaceae; Yersinia.
OX NCBI_TaxID=632;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=KIM6;
RX PubMed=9026634; DOI=10.1111/j.1365-2958.1996.tb02512.x;
RA Hornung J.M., Jones H.A., Perry R.D.;
RT "The hmu locus of Yersinia pestis is essential for utilization of free
RT haemin and haem-protein complexes as iron sources.";
RL Mol. Microbiol. 20:725-739(1996).
RN [2]
RP SEQUENCE REVISION.
RA Hornung J.M., Jones H.A., Bertolino V.J., Perry R.D.;
RL Submitted (OCT-1998) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CO-92 / Biovar Orientalis;
RX PubMed=11586360; DOI=10.1038/35097083;
RA Parkhill J., Wren B.W., Thomson N.R., Titball R.W., Holden M.T.G.,
RA Prentice M.B., Sebaihia M., James K.D., Churcher C.M., Mungall K.L.,
RA Baker S., Basham D., Bentley S.D., Brooks K., Cerdeno-Tarraga A.-M.,
RA Chillingworth T., Cronin A., Davies R.M., Davis P., Dougan G., Feltwell T.,
RA Hamlin N., Holroyd S., Jagels K., Karlyshev A.V., Leather S., Moule S.,
RA Oyston P.C.F., Quail M.A., Rutherford K.M., Simmonds M., Skelton J.,
RA Stevens K., Whitehead S., Barrell B.G.;
RT "Genome sequence of Yersinia pestis, the causative agent of plague.";
RL Nature 413:523-527(2001).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=KIM10+ / Biovar Mediaevalis;
RX PubMed=12142430; DOI=10.1128/jb.184.16.4601-4611.2002;
RA Deng W., Burland V., Plunkett G. III, Boutin A., Mayhew G.F., Liss P.,
RA Perna N.T., Rose D.J., Mau B., Zhou S., Schwartz D.C., Fetherston J.D.,
RA Lindler L.E., Brubaker R.R., Plano G.V., Straley S.C., McDonough K.A.,
RA Nilles M.L., Matson J.S., Blattner F.R., Perry R.D.;
RT "Genome sequence of Yersinia pestis KIM.";
RL J. Bacteriol. 184:4601-4611(2002).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=91001 / Biovar Mediaevalis;
RX PubMed=15368893; DOI=10.1093/dnares/11.3.179;
RA Song Y., Tong Z., Wang J., Wang L., Guo Z., Han Y., Zhang J., Pei D.,
RA Zhou D., Qin H., Pang X., Han Y., Zhai J., Li M., Cui B., Qi Z., Jin L.,
RA Dai R., Chen F., Li S., Ye C., Du Z., Lin W., Wang J., Yu J., Yang H.,
RA Wang J., Huang P., Yang R.;
RT "Complete genome sequence of Yersinia pestis strain 91001, an isolate
RT avirulent to humans.";
RL DNA Res. 11:179-197(2004).
CC -!- FUNCTION: Part of the binding-protein-dependent transport system for
CC hemin.
CC -!- SUBCELLULAR LOCATION: Periplasm {ECO:0000305}.
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DR EMBL; U60647; AAC64868.1; -; Genomic_DNA.
DR EMBL; AL590842; CAL18967.1; -; Genomic_DNA.
DR EMBL; AE009952; AAM84129.1; -; Genomic_DNA.
DR EMBL; AE017042; AAS60707.1; -; Genomic_DNA.
DR PIR; AE0035; AE0035.
DR PIR; T12071; T12071.
DR RefSeq; WP_002209060.1; NZ_WUCM01000046.1.
DR RefSeq; YP_002345363.1; NC_003143.1.
DR PDB; 3MD9; X-ray; 1.50 A; A/B=26-279.
DR PDBsum; 3MD9; -.
DR AlphaFoldDB; Q56991; -.
DR SMR; Q56991; -.
DR DIP; DIP-60002N; -.
DR IntAct; Q56991; 3.
DR STRING; 214092.YPO0281; -.
DR TCDB; 3.A.1.14.5; the atp-binding cassette (abc) superfamily.
DR PaxDb; Q56991; -.
DR DNASU; 1145488; -.
DR EnsemblBacteria; AAM84129; AAM84129; y0541.
DR EnsemblBacteria; AAS60707; AAS60707; YP_0436.
DR GeneID; 57974320; -.
DR KEGG; ype:YPO0281; -.
DR KEGG; ypk:y0541; -.
DR KEGG; ypm:YP_0436; -.
DR PATRIC; fig|214092.21.peg.514; -.
DR eggNOG; COG4558; Bacteria.
DR HOGENOM; CLU_038034_6_0_6; -.
DR OMA; PNVGYMR; -.
DR EvolutionaryTrace; Q56991; -.
DR Proteomes; UP000000815; Chromosome.
DR Proteomes; UP000001019; Chromosome.
DR Proteomes; UP000002490; Chromosome.
DR GO; GO:0042597; C:periplasmic space; IEA:UniProtKB-SubCell.
DR GO; GO:0006811; P:ion transport; IEA:UniProtKB-KW.
DR GO; GO:0055072; P:iron ion homeostasis; IEA:UniProtKB-KW.
DR InterPro; IPR002491; ABC_transptr_periplasmic_BD.
DR Pfam; PF01497; Peripla_BP_2; 1.
DR PROSITE; PS50983; FE_B12_PBP; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Ion transport; Iron; Iron transport; Periplasm;
KW Reference proteome; Signal; Transport.
FT SIGNAL 1..25
FT /evidence="ECO:0000255"
FT CHAIN 26..279
FT /note="Hemin-binding periplasmic protein HmuT"
FT /id="PRO_0000021447"
FT DOMAIN 28..279
FT /note="Fe/B12 periplasmic-binding"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00344"
FT STRAND 29..33
FT /evidence="ECO:0007829|PDB:3MD9"
FT HELIX 34..42
FT /evidence="ECO:0007829|PDB:3MD9"
FT HELIX 46..48
FT /evidence="ECO:0007829|PDB:3MD9"
FT STRAND 49..52
FT /evidence="ECO:0007829|PDB:3MD9"
FT HELIX 60..64
FT /evidence="ECO:0007829|PDB:3MD9"
FT HELIX 76..80
FT /evidence="ECO:0007829|PDB:3MD9"
FT STRAND 85..90
FT /evidence="ECO:0007829|PDB:3MD9"
FT HELIX 96..104
FT /evidence="ECO:0007829|PDB:3MD9"
FT STRAND 108..112
FT /evidence="ECO:0007829|PDB:3MD9"
FT HELIX 118..132
FT /evidence="ECO:0007829|PDB:3MD9"
FT HELIX 135..150
FT /evidence="ECO:0007829|PDB:3MD9"
FT STRAND 160..165
FT /evidence="ECO:0007829|PDB:3MD9"
FT STRAND 168..170
FT /evidence="ECO:0007829|PDB:3MD9"
FT STRAND 173..175
FT /evidence="ECO:0007829|PDB:3MD9"
FT STRAND 177..179
FT /evidence="ECO:0007829|PDB:3MD9"
FT HELIX 180..187
FT /evidence="ECO:0007829|PDB:3MD9"
FT STRAND 191..193
FT /evidence="ECO:0007829|PDB:3MD9"
FT STRAND 198..202
FT /evidence="ECO:0007829|PDB:3MD9"
FT HELIX 205..211
FT /evidence="ECO:0007829|PDB:3MD9"
FT STRAND 214..219
FT /evidence="ECO:0007829|PDB:3MD9"
FT HELIX 220..226
FT /evidence="ECO:0007829|PDB:3MD9"
FT HELIX 229..234
FT /evidence="ECO:0007829|PDB:3MD9"
FT HELIX 238..240
FT /evidence="ECO:0007829|PDB:3MD9"
FT HELIX 242..245
FT /evidence="ECO:0007829|PDB:3MD9"
FT STRAND 249..252
FT /evidence="ECO:0007829|PDB:3MD9"
FT HELIX 254..258
FT /evidence="ECO:0007829|PDB:3MD9"
FT HELIX 264..277
FT /evidence="ECO:0007829|PDB:3MD9"
SQ SEQUENCE 279 AA; 29574 MW; 190547D960C93763 CRC64;
MRLRLLSLPF ILSLCAPLLP LNTLAAERIV TIGGDVTEIA YALGAGDEIV ARDSTSQQPQ
AAQKLPDVGY MRTLNAEGIL AMKPTMLLVS ELAQPSLVLT QIASSGVNVV TVPGQTTPES
VAMKINAVAT ALHQTEKGQK LIEDYQQRLA AVNKTPLPVK VLFVMSHGGL TPMAAGQNTA
ADAMIRAAGG SNAMQGFSRY RPLSQEGVIA SAPDLLLITT DGVKALGSSE NIWKLPGMAL
TPAGKHKRLL VVDDMALLGF GLETPQVLAQ LREKMEQMQ
