HMUU_YERPE
ID HMUU_YERPE Reviewed; 334 AA.
AC Q56992; Q0WK26;
DT 01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT 30-MAY-2000, sequence version 2.
DT 25-MAY-2022, entry version 151.
DE RecName: Full=Hemin transport system permease protein HmuU;
GN Name=hmuU; OrderedLocusNames=YPO0280, y0540, YP_0435;
OS Yersinia pestis.
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Yersiniaceae; Yersinia.
OX NCBI_TaxID=632;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=KIM6;
RX PubMed=9026634; DOI=10.1111/j.1365-2958.1996.tb02512.x;
RA Hornung J.M., Jones H.A., Perry R.D.;
RT "The hmu locus of Yersinia pestis is essential for utilization of free
RT haemin and haem-protein complexes as iron sources.";
RL Mol. Microbiol. 20:725-739(1996).
RN [2]
RP SEQUENCE REVISION TO 270.
RC STRAIN=KIM6;
RA Hornung J.M., Jones H.A., Bertolino V.J., Perry R.D.;
RT "hmuRSTUV of Yersinia pestis encodes an ABC transport system necessary for
RT hemin utilization.";
RL Submitted (OCT-1998) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CO-92 / Biovar Orientalis;
RX PubMed=11586360; DOI=10.1038/35097083;
RA Parkhill J., Wren B.W., Thomson N.R., Titball R.W., Holden M.T.G.,
RA Prentice M.B., Sebaihia M., James K.D., Churcher C.M., Mungall K.L.,
RA Baker S., Basham D., Bentley S.D., Brooks K., Cerdeno-Tarraga A.-M.,
RA Chillingworth T., Cronin A., Davies R.M., Davis P., Dougan G., Feltwell T.,
RA Hamlin N., Holroyd S., Jagels K., Karlyshev A.V., Leather S., Moule S.,
RA Oyston P.C.F., Quail M.A., Rutherford K.M., Simmonds M., Skelton J.,
RA Stevens K., Whitehead S., Barrell B.G.;
RT "Genome sequence of Yersinia pestis, the causative agent of plague.";
RL Nature 413:523-527(2001).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=KIM10+ / Biovar Mediaevalis;
RX PubMed=12142430; DOI=10.1128/jb.184.16.4601-4611.2002;
RA Deng W., Burland V., Plunkett G. III, Boutin A., Mayhew G.F., Liss P.,
RA Perna N.T., Rose D.J., Mau B., Zhou S., Schwartz D.C., Fetherston J.D.,
RA Lindler L.E., Brubaker R.R., Plano G.V., Straley S.C., McDonough K.A.,
RA Nilles M.L., Matson J.S., Blattner F.R., Perry R.D.;
RT "Genome sequence of Yersinia pestis KIM.";
RL J. Bacteriol. 184:4601-4611(2002).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=91001 / Biovar Mediaevalis;
RX PubMed=15368893; DOI=10.1093/dnares/11.3.179;
RA Song Y., Tong Z., Wang J., Wang L., Guo Z., Han Y., Zhang J., Pei D.,
RA Zhou D., Qin H., Pang X., Han Y., Zhai J., Li M., Cui B., Qi Z., Jin L.,
RA Dai R., Chen F., Li S., Ye C., Du Z., Lin W., Wang J., Yu J., Yang H.,
RA Wang J., Huang P., Yang R.;
RT "Complete genome sequence of Yersinia pestis strain 91001, an isolate
RT avirulent to humans.";
RL DNA Res. 11:179-197(2004).
CC -!- FUNCTION: Part of the binding-protein-dependent transport system for
CC hemin; probably responsible for the translocation of the substrate
CC across the membrane.
CC -!- INTERACTION:
CC Q56992; Q56993: hmuV; NbExp=3; IntAct=EBI-16023192, EBI-2866017;
CC -!- SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the binding-protein-dependent transport system
CC permease family. FecCD subfamily. {ECO:0000305}.
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DR EMBL; U60647; AAC64869.1; -; Genomic_DNA.
DR EMBL; AL590842; CAL18966.1; -; Genomic_DNA.
DR EMBL; AE009952; AAM84128.1; -; Genomic_DNA.
DR EMBL; AE017042; AAS60706.1; -; Genomic_DNA.
DR PIR; AD0035; AD0035.
DR PIR; T12072; T12072.
DR RefSeq; WP_002209059.1; NZ_WUCM01000046.1.
DR RefSeq; YP_002345362.1; NC_003143.1.
DR PDB; 4G1U; X-ray; 3.01 A; A/B=1-334.
DR PDBsum; 4G1U; -.
DR AlphaFoldDB; Q56992; -.
DR SMR; Q56992; -.
DR DIP; DIP-60000N; -.
DR IntAct; Q56992; 2.
DR STRING; 214092.YPO0280; -.
DR TCDB; 3.A.1.14.5; the atp-binding cassette (abc) superfamily.
DR PaxDb; Q56992; -.
DR EnsemblBacteria; AAM84128; AAM84128; y0540.
DR EnsemblBacteria; AAS60706; AAS60706; YP_0435.
DR GeneID; 66843246; -.
DR KEGG; ype:YPO0280; -.
DR KEGG; ypk:y0540; -.
DR KEGG; ypm:YP_0435; -.
DR PATRIC; fig|214092.21.peg.513; -.
DR eggNOG; COG0609; Bacteria.
DR HOGENOM; CLU_013016_0_3_6; -.
DR OMA; MQGVFGN; -.
DR Proteomes; UP000000815; Chromosome.
DR Proteomes; UP000001019; Chromosome.
DR Proteomes; UP000002490; Chromosome.
DR GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR GO; GO:0022857; F:transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0033214; P:siderophore-dependent iron import into cell; IBA:GO_Central.
DR Gene3D; 1.10.3470.10; -; 1.
DR InterPro; IPR037294; ABC_BtuC-like.
DR InterPro; IPR000522; ABC_transptr_permease_BtuC.
DR PANTHER; PTHR30472; PTHR30472; 1.
DR Pfam; PF01032; FecCD; 1.
DR SUPFAM; SSF81345; SSF81345; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Cell inner membrane; Cell membrane; Ion transport; Iron;
KW Iron transport; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix; Transport.
FT CHAIN 1..334
FT /note="Hemin transport system permease protein HmuU"
FT /id="PRO_0000060053"
FT TRANSMEM 9..29
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 60..80
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 96..116
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 117..137
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 149..169
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 191..211
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 244..264
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 278..298
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 306..326
FT /note="Helical"
FT /evidence="ECO:0000255"
FT HELIX 7..27
FT /evidence="ECO:0007829|PDB:4G1U"
FT TURN 49..54
FT /evidence="ECO:0007829|PDB:4G1U"
FT HELIX 55..79
FT /evidence="ECO:0007829|PDB:4G1U"
FT TURN 87..91
FT /evidence="ECO:0007829|PDB:4G1U"
FT HELIX 92..104
FT /evidence="ECO:0007829|PDB:4G1U"
FT HELIX 115..140
FT /evidence="ECO:0007829|PDB:4G1U"
FT HELIX 145..169
FT /evidence="ECO:0007829|PDB:4G1U"
FT HELIX 173..181
FT /evidence="ECO:0007829|PDB:4G1U"
FT TURN 182..184
FT /evidence="ECO:0007829|PDB:4G1U"
FT HELIX 191..210
FT /evidence="ECO:0007829|PDB:4G1U"
FT HELIX 212..217
FT /evidence="ECO:0007829|PDB:4G1U"
FT HELIX 218..220
FT /evidence="ECO:0007829|PDB:4G1U"
FT HELIX 222..227
FT /evidence="ECO:0007829|PDB:4G1U"
FT HELIX 232..254
FT /evidence="ECO:0007829|PDB:4G1U"
FT TURN 260..262
FT /evidence="ECO:0007829|PDB:4G1U"
FT HELIX 263..269
FT /evidence="ECO:0007829|PDB:4G1U"
FT HELIX 276..298
FT /evidence="ECO:0007829|PDB:4G1U"
FT HELIX 309..325
FT /evidence="ECO:0007829|PDB:4G1U"
SQ SEQUENCE 334 AA; 35540 MW; 6D6C1B4ED5C94EC7 CRC64;
MNGRVQPRLM LGFLLILLVI LALGSANMGA LSLSFRTLWN TSTNDAMWHI WLNIRLPRVL
LAVVVGCALA VSGTIMQGLF RNPLADPGLL GISSGAALCV GLIIVMPFSL PPLLALYSHM
VGAFIGSLAI STIIFTLSRW GHGNLARLLL AGIAINALCG AAVGVLTYIS DDQQLRQFSL
WSMGSLGQAQ WSTLLVASSL ILPTCILGLL QARQLNLLQL GDEEAHYLGV NVRQAKLRLL
LLSAILIGAA VAVSGVIGFI GLVVPHLIRM RIGADHRWLL PGAALGGACL LLTADTLART
LVAPAEMPVG LLTSLLGGPY FLWLILRQRE QRSG
