HMUV_ENTCL
ID HMUV_ENTCL Reviewed; 261 AA.
AC Q84EY8;
DT 12-DEC-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2003, sequence version 1.
DT 03-AUG-2022, entry version 81.
DE RecName: Full=Hemin import ATP-binding protein HmuV {ECO:0000255|HAMAP-Rule:MF_01718};
DE EC=7.6.2.- {ECO:0000255|HAMAP-Rule:MF_01718};
GN Name=hmuV {ECO:0000255|HAMAP-Rule:MF_01718}; Synonyms=ehuV;
OS Enterobacter cloacae.
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Enterobacter; Enterobacter cloacae complex.
OX NCBI_TaxID=550;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=Z-2376;
RX PubMed=15039350; DOI=10.1128/iai.72.4.2254-2262.2004;
RA Roggenkamp A., Hoffmann H., Hornef M.W.;
RT "Growth control of small-colony variants by genetic regulation of the hemin
RT uptake system.";
RL Infect. Immun. 72:2254-2262(2004).
CC -!- FUNCTION: Part of the ABC transporter complex HmuTUV involved in hemin
CC import. Responsible for energy coupling to the transport system.
CC {ECO:0000255|HAMAP-Rule:MF_01718}.
CC -!- SUBUNIT: The complex is composed of two ATP-binding proteins (HmuV),
CC two transmembrane proteins (HmuU) and a solute-binding protein (HmuT).
CC {ECO:0000255|HAMAP-Rule:MF_01718}.
CC -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-
CC Rule:MF_01718}; Peripheral membrane protein {ECO:0000255|HAMAP-
CC Rule:MF_01718}.
CC -!- SIMILARITY: Belongs to the ABC transporter superfamily. Heme (hemin)
CC importer (TC 3.A.1.14.5) family. {ECO:0000255|HAMAP-Rule:MF_01718}.
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DR EMBL; AJ538328; CAD61866.1; -; Genomic_DNA.
DR AlphaFoldDB; Q84EY8; -.
DR SMR; Q84EY8; -.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR Gene3D; 3.40.50.300; -; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR003439; ABC_transporter-like_ATP-bd.
DR InterPro; IPR017871; ABC_transporter-like_CS.
DR InterPro; IPR027417; P-loop_NTPase.
DR Pfam; PF00005; ABC_tran; 1.
DR SMART; SM00382; AAA; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
DR PROSITE; PS00211; ABC_TRANSPORTER_1; 1.
DR PROSITE; PS50893; ABC_TRANSPORTER_2; 1.
DR PROSITE; PS51261; HMUV; 1.
PE 3: Inferred from homology;
KW ATP-binding; Cell inner membrane; Cell membrane; Membrane;
KW Nucleotide-binding; Translocase; Transport.
FT CHAIN 1..261
FT /note="Hemin import ATP-binding protein HmuV"
FT /id="PRO_0000269593"
FT DOMAIN 5..241
FT /note="ABC transporter"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01718"
FT BINDING 37..44
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01718"
SQ SEQUENCE 261 AA; 28817 MW; 03609C4E99AFAD4E CRC64;
MAERYTAENL TFTRSGRTLT DNVSLSLSQG ELVTLIGPNG AGKSTLLRLL TGYLKPDSGG
CSLAGKALDE WHPQTLSRYR AVMRQQSQPG FDWQVEEIVG MGRAPWTRHP EPSIVREVLQ
LTGCLPLAGR RYHALSGGEQ QRVQLARALA QLGVTERRAA WLFLDEPTSA LDLYHQQHLL
RLLKSLTRQG HLHACVVLHD LNLAALWSDR ILLLHNGRIV SQGIPETVLQ ADALAHWYGA
QVHVGMTSGA RRTAGFSRPL A