HMUV_PSEAE
ID HMUV_PSEAE Reviewed; 255 AA.
AC O68877; Q7DC58;
DT 12-DEC-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-AUG-1998, sequence version 1.
DT 03-AUG-2022, entry version 134.
DE RecName: Full=Hemin import ATP-binding protein HmuV {ECO:0000255|HAMAP-Rule:MF_01718};
DE EC=7.6.2.- {ECO:0000255|HAMAP-Rule:MF_01718};
GN Name=hmuV {ECO:0000255|HAMAP-Rule:MF_01718}; Synonyms=phuV;
GN OrderedLocusNames=PA4706;
OS Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM
OS 14847 / LMG 12228 / 1C / PRS 101 / PAO1).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Pseudomonadales;
OC Pseudomonadaceae; Pseudomonas.
OX NCBI_TaxID=208964;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C /
RC PRS 101 / PAO1;
RX PubMed=8633080; DOI=10.1073/pnas.93.9.4409;
RA Ochsner U.A., Vasil M.L.;
RT "Gene repression by the ferric uptake regulator in Pseudomonas aeruginosa:
RT cycle selection of iron-regulated genes.";
RL Proc. Natl. Acad. Sci. U.S.A. 93:4409-4414(1996).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C /
RC PRS 101 / PAO1;
RX PubMed=10984043; DOI=10.1038/35023079;
RA Stover C.K., Pham X.-Q.T., Erwin A.L., Mizoguchi S.D., Warrener P.,
RA Hickey M.J., Brinkman F.S.L., Hufnagle W.O., Kowalik D.J., Lagrou M.,
RA Garber R.L., Goltry L., Tolentino E., Westbrock-Wadman S., Yuan Y.,
RA Brody L.L., Coulter S.N., Folger K.R., Kas A., Larbig K., Lim R.M.,
RA Smith K.A., Spencer D.H., Wong G.K.-S., Wu Z., Paulsen I.T., Reizer J.,
RA Saier M.H. Jr., Hancock R.E.W., Lory S., Olson M.V.;
RT "Complete genome sequence of Pseudomonas aeruginosa PAO1, an opportunistic
RT pathogen.";
RL Nature 406:959-964(2000).
CC -!- FUNCTION: Part of the ABC transporter complex HmuTUV involved in hemin
CC import. Responsible for energy coupling to the transport system.
CC {ECO:0000255|HAMAP-Rule:MF_01718}.
CC -!- SUBUNIT: The complex is composed of two ATP-binding proteins (HmuV),
CC two transmembrane proteins (HmuU) and a solute-binding protein (HmuT).
CC {ECO:0000255|HAMAP-Rule:MF_01718}.
CC -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-
CC Rule:MF_01718}; Peripheral membrane protein {ECO:0000255|HAMAP-
CC Rule:MF_01718}.
CC -!- SIMILARITY: Belongs to the ABC transporter superfamily. Heme (hemin)
CC importer (TC 3.A.1.14.5) family. {ECO:0000255|HAMAP-Rule:MF_01718}.
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DR EMBL; AF055999; AAC13285.1; -; Genomic_DNA.
DR EMBL; AE004091; AAG08092.1; -; Genomic_DNA.
DR PIR; F83058; F83058.
DR RefSeq; NP_253394.1; NC_002516.2.
DR RefSeq; WP_003095098.1; NZ_QZGE01000018.1.
DR AlphaFoldDB; O68877; -.
DR SMR; O68877; -.
DR STRING; 287.DR97_2048; -.
DR TCDB; 3.A.1.14.21; the atp-binding cassette (abc) superfamily.
DR PaxDb; O68877; -.
DR PRIDE; O68877; -.
DR EnsemblBacteria; AAG08092; AAG08092; PA4706.
DR GeneID; 881536; -.
DR KEGG; pae:PA4706; -.
DR PATRIC; fig|208964.12.peg.4930; -.
DR PseudoCAP; PA4706; -.
DR HOGENOM; CLU_000604_1_11_6; -.
DR InParanoid; O68877; -.
DR OMA; DMHHQIN; -.
DR PhylomeDB; O68877; -.
DR BioCyc; PAER208964:G1FZ6-4812-MON; -.
DR Proteomes; UP000002438; Chromosome.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR Gene3D; 3.40.50.300; -; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR003439; ABC_transporter-like_ATP-bd.
DR InterPro; IPR027417; P-loop_NTPase.
DR Pfam; PF00005; ABC_tran; 1.
DR SMART; SM00382; AAA; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
DR PROSITE; PS50893; ABC_TRANSPORTER_2; 1.
DR PROSITE; PS51261; HMUV; 1.
PE 3: Inferred from homology;
KW ATP-binding; Cell inner membrane; Cell membrane; Membrane;
KW Nucleotide-binding; Reference proteome; Translocase; Transport.
FT CHAIN 1..255
FT /note="Hemin import ATP-binding protein HmuV"
FT /id="PRO_0000269609"
FT DOMAIN 2..238
FT /note="ABC transporter"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01718"
FT BINDING 34..41
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01718"
SQ SEQUENCE 255 AA; 27525 MW; F7CB956D8B205BA3 CRC64;
MLRVENLSIR RGGKTVLEGL ELELRPGEML GVLGPNGAGK STLLGALCGE LEPAEGLVLL
DERGLDDWPG VARAQRLAVL PQSSSLGFAF PVEAVVGFGR LPHSSGRERD VQIVAEALAA
ADASHLAGRS YLALSGGERQ RVHLARVLAQ LWPGEPGQVL LLDEPTSALD PLHQHTTLQA
VHDFARRGAS VLVILHDLNL AARYCDRLLL LQNGRPHLLG TPEEVLRPEP LRAVFGLEVL
VQRHPERGHP LIVAR
