ID   HMVA_METVO              Reviewed;          99 AA.
AC   Q03576;
DT   01-OCT-1993, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1993, sequence version 1.
DT   25-MAY-2022, entry version 71.
DE   RecName: Full=DNA-binding protein HmvA;
GN   Name=hmvA;
OS   Methanococcus voltae.
OC   Archaea; Euryarchaeota; Methanomada group; Methanococci; Methanococcales;
OC   Methanococcaceae; Methanococcus.
OX   NCBI_TaxID=2188;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ATCC 33273 / DSM 1537 / NBRC 100457 / OCM 70 / PS;
RX   PubMed=8464744; DOI=10.1093/nar/21.6.1491;
RA   Agha Amiri K., Klein A.;
RT   "Nucleotide sequence of a gene encoding a histone-like protein in the
RT   archaeon Methanococcus voltae.";
RL   Nucleic Acids Res. 21:1491-1491(1993).
CC   -!- FUNCTION: Binds and compact DNA (95 to 150 base pairs) to form
CC       nucleosome-like structures that contain positive DNA supercoils.
CC       Increases the resistance of DNA to thermal denaturation (in vitro).
CC       {ECO:0000250|UniProtKB:P19267}.
CC   -!- SUBUNIT: Homodimer or heterodimer with another histone. Dimers then
CC       assemble into higher oligomers, with the DNA wrapped around the protein
CC       core (By similarity). {ECO:0000250|UniProtKB:P19267}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}. Chromosome
CC       {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the archaeal histone HMF family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; X69792; CAA49447.1; -; Genomic_DNA.
DR   PIR; S78493; S78493.
DR   AlphaFoldDB; Q03576; -.
DR   SMR; Q03576; -.
DR   GO; GO:0005694; C:chromosome; IEA:UniProtKB-SubCell.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0046982; F:protein heterodimerization activity; IEA:InterPro.
DR   Gene3D; 1.10.20.10; -; 1.
DR   InterPro; IPR003958; CBFA_NFYB_domain.
DR   InterPro; IPR009072; Histone-fold.
DR   Pfam; PF00808; CBFD_NFYB_HMF; 1.
DR   SUPFAM; SSF47113; SSF47113; 1.
PE   3: Inferred from homology;
KW   Chromosome; Cytoplasm; DNA-binding.
FT   CHAIN           1..99
FT                   /note="DNA-binding protein HmvA"
FT                   /id="PRO_0000155006"
FT   REGION          52..55
FT                   /note="Interaction with DNA"
FT                   /evidence="ECO:0000250|UniProtKB:P19267"
FT   SITE            12
FT                   /note="Interaction with DNA"
FT                   /evidence="ECO:0000250|UniProtKB:P19267"
SQ   SEQUENCE   99 AA;  11379 MW;  838CFFC6B03CFC82 CRC64;
     MIPKGTVKRI MKDNTEMYVS TESVVALVDI LQEMIVTTTK IAEENAAKDK RKTIKARDIE
     ECDAERLKEK ILQVSERTEK VNMLANEILH VIASELERY