ID   HMW1_MYCGA              Reviewed;        1969 AA.
AC   Q7NAT4;
DT   28-JUL-2009, integrated into UniProtKB/Swiss-Prot.
DT   15-JUN-2010, sequence version 2.
DT   03-AUG-2022, entry version 67.
DE   RecName: Full=Cytadherence high molecular weight protein 1;
DE   AltName: Full=Cytadherence accessory protein 1;
GN   Name=hlp1; Synonyms=hmw3; OrderedLocusNames=MYCGA5510; ORFNames=MGA_0306;
OS   Mycoplasma gallisepticum (strain R(low / passage 15 / clone 2))
OS   (Mycoplasmoides gallisepticum).
OC   Bacteria; Tenericutes; Mollicutes; Mycoplasmataceae; Mycoplasma.
OX   NCBI_TaxID=710127;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=R(low / passage 15 / clone 2);
RX   PubMed=12949158; DOI=10.1099/mic.0.26427-0;
RA   Papazisi L., Gorton T.S., Kutish G., Markham P.F., Browning G.F.,
RA   Nguyen D.K., Swartzell S., Madan A., Mahairas G., Geary S.J.;
RT   "The complete genome sequence of the avian pathogen Mycoplasma
RT   gallisepticum strain R(low).";
RL   Microbiology 149:2307-2316(2003).
CC   -!- FUNCTION: Component of the cytoskeleton-like structure which stabilizes
CC       the shape of the wall-less Mycoplasma. This cytoskeleton-like network
CC       of accessory proteins containing HMW proteins 1 to 5 allows the proper
CC       anchoring of cytadhesin proteins in the mycoplasmal membrane at the
CC       attachment organelle (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell projection, attachment organelle membrane
CC       {ECO:0000250}. Note=Localizes specifically to the attachment membrane.
CC       {ECO:0000250}.
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DR   EMBL; AE015450; AAP56901.2; -; Genomic_DNA.
DR   RefSeq; WP_011113808.1; NC_004829.2.
DR   AlphaFoldDB; Q7NAT4; -.
DR   SMR; Q7NAT4; -.
DR   KEGG; mga:MGA_0306; -.
DR   PATRIC; fig|233150.7.peg.623; -.
DR   HOGENOM; CLU_235452_0_0_14; -.
DR   OrthoDB; 2038359at2; -.
DR   Proteomes; UP000001418; Chromosome.
DR   GO; GO:0033111; C:attachment organelle membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0042995; C:cell projection; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR   GO; GO:0020035; P:adhesion of symbiont to microvasculature; IEA:UniProtKB-KW.
DR   Gene3D; 3.30.70.3600; -; 7.
DR   InterPro; IPR021199; Cytadherence_HMW-1_N.
DR   InterPro; IPR022466; EAGR_box.
DR   InterPro; IPR038145; EAGR_sf.
DR   Pfam; PF16713; EAGR_box; 7.
DR   TIGRFAMs; TIGR03834; EAGR_box; 7.
DR   TIGRFAMs; TIGR03836; termin_org_HMW1; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Cell projection; Coiled coil; Cytadherence; Membrane;
KW   Reference proteome; Repeat; Virulence.
FT   CHAIN           1..1969
FT                   /note="Cytadherence high molecular weight protein 1"
FT                   /id="PRO_0000380119"
FT   REPEAT          148..166
FT                   /note="HAT 1"
FT   REPEAT          258..278
FT                   /note="HAT 2"
FT   REPEAT          300..331
FT                   /note="HAT 3"
FT   REPEAT          333..353
FT                   /note="HAT 4"
FT   REPEAT          477..497
FT                   /note="HAT 5"
FT   REPEAT          959..997
FT                   /note="HAT 6"
FT   REPEAT          1029..1067
FT                   /note="HAT 7"
FT   REGION          174..244
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          294..319
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          365..393
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          1000..1027
FT                   /evidence="ECO:0000255"
FT   COILED          1082..1190
FT                   /evidence="ECO:0000255"
FT   COILED          1547..1621
FT                   /evidence="ECO:0000255"
FT   COILED          1758..1790
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        176..241
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        372..390
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1969 AA;  227910 MW;  D7418FDEA5FCE98F CRC64;
     MPKMIKGTEF IVAKKTKNKK KNHFEDIQTT NDINEEESEA IFGNLYDGAD EVLPASLAYE
     NGQLPEDGSI QVAFDADDNA YYISYDPENE IFIEPYEKYE LDVSALYDAE GNPFDFFANY
     HVEGAETSQE EESGEYWEQF VGVEGYGYYD ENEEWVWTGY FDEDNKFIPN EEEKPAEVEA
     LEEESEATEE VVEQEPQEEV QAEEVVEEPV SQEQPEEEVA AEEYAEAAQE EYEEQPESEQ
     EGSGEYWEQF VGVEGYGYYD ENNDWVWTGY FDENNNFVPD QYYDEDAAVA GDEQVEEYSA
     QQEQVQEEYE QQPEQEGSGE YWEQFVGVEG YGYYDENNDW VWTGYFDENN NFVPDQYYDE
     YAQPVSEEQY SESVSEEQEP ASEEQVAEEP AQVEEVAVEQ VPEETQPEQV QEKVQAYEHV
     EEQQPEEVFA DAIDEHYDEI THVEDKAVEE EQIQTDNVVS SDEINWSNYV GNEDYGYYDE
     NNEWVWKGYF NEYGMFIPQE EDYTDSIPVD EQPVEQTADL AEQNEEEVIE ETTASDEIVQ
     VEEEVESEPV VPTVSDDLVA LEQPFEFDTQ QFVGNIDFGY YDESSEWIWT GHFDKDGKFF
     DFDGNLVYSP QEGVKPVEVP KPTDLTNQIP QNALVVAEPD VFSEDTIQQV DESQFDVGEE
     LVVRGLLNPA STPVQPQELN IKPVFEEEKL NLPVLANEVS LQPQVDYSKR SDFDQLVTQT
     PVVLEDVVAD DLISVDTKGF VPELSQPTFA PKAVSQDQFK LVQPVVSQPK FDQITHLTDE
     IKMDVNVTSS DVDVQPIQIN PSLEVASEPS KLDIFVKKPA VELKKIEFIE PVSEKIDLQI
     FEQQEIVTKP VSTIQKPTYT DETVSVSVNA IDETTSETDT IVQVTPTTSE ASDFDINKIL
     NTKPVETITV ELPKDEPKLV TGVHVSLVDV EAKPVEEIVK FDSPKPSVSE VVVEKEDKLT
     LVEEEPFFNK FIGNEQYGYY NNKNVWIWTG YFDDQNNFVS DKDSKTQKVD QLIEEFNKQE
     AIKKTEEVEA KKASEPFYNK YIGNKQFGYY NDKNVWIWNG YFDENDQFVP DQSWTKRSEK
     LIEDELQKQR IHELELELAQ AQQAILESTK LKDQEVAKIK EEVLKVQQEA IKAKEVATLR
     NFVPKGSPLL NPAKEVENSM IVYQEDKLEV NDLRNELSKL KTQREEFDNF SKIRDLDVIN
     LYNASTSHRG MDYVFSGFEK KEEQFVKKPL HFLEEVKADP VQVAKEETIS NLDQLLKQDP
     HLLLAKKTDK SVSPQASLTV LADQKEVELT QQAVRKQAEA IEAERVDVIK PLEQVQLNQS
     RSLLDDLTPK FEVKPSLIKD DVIQPKYNDD LEPIEQLQFK QERSLLDDYM PKFDDQGLFS
     KVEFKLPTVN KEYRPKVEPI DVIKPLEPVR INKERSLLDD YLPPKLNAQP TFEKTELDLG
     LEKPLANGEL YEELKAEFST TITPADSKDM IDQLLEETND LITSSTQTRS TKIHSFSKSP
     LKTEPEPILD TKFDDKFIEL DENQGFDQLI VESDDELLTD VVQEQVSVNQ IAVTNEEYKK
     DMAELKQFLE KRSEELFKQY FSKFEELTKL QMESFNQIKN ELRSEMNEIR DEVRSNKLAL
     TSEITEEIYP SAPKVSRKQR GVHGFSEPTS EFDFDNSLSL VNENNYDLYE LLDRIINYED
     VPLTSSNLFK AEEYQAKVKQ SVYNIKLILK NSEAEATKNY NYILSTLKNE ITLLQKDLPI
     ISSQLNKLQH DLRAKQLNRG DYKFVQEQIQ ELRAEHANKT RAISFYNKKV SDLKSIYAQQ
     IRKIKSDYKK ISDLANKRKV SSDYIDQALQ SFETARVSQP NIKRNYEQLY RNQLQQNVNA
     NYGNFRRYDP LIENHGYEYF SNHQPREFFS ELESIDNDIF SSNDLIYSNR NTYLDENFRI
     NDYELTSNFN DIDAIYGMDK LRLPPFEPSN LVNDMEFNSS FDIDFDTDF