HMW1_MYCGE
ID HMW1_MYCGE Reviewed; 1139 AA.
AC Q49413; Q49365;
DT 01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1996, sequence version 1.
DT 03-AUG-2022, entry version 99.
DE RecName: Full=Cytadherence high molecular weight protein 1;
DE AltName: Full=Cytadherence accessory protein 1;
GN Name=hmw1; OrderedLocusNames=MG312;
OS Mycoplasma genitalium (strain ATCC 33530 / DSM 19775 / NCTC 10195 / G37)
OS (Mycoplasmoides genitalium).
OC Bacteria; Tenericutes; Mollicutes; Mycoplasmataceae; Mycoplasma.
OX NCBI_TaxID=243273;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 33530 / DSM 19775 / NCTC 10195 / G37;
RX PubMed=7569993; DOI=10.1126/science.270.5235.397;
RA Fraser C.M., Gocayne J.D., White O., Adams M.D., Clayton R.A.,
RA Fleischmann R.D., Bult C.J., Kerlavage A.R., Sutton G.G., Kelley J.M.,
RA Fritchman J.L., Weidman J.F., Small K.V., Sandusky M., Fuhrmann J.L.,
RA Nguyen D.T., Utterback T.R., Saudek D.M., Phillips C.A., Merrick J.M.,
RA Tomb J.-F., Dougherty B.A., Bott K.F., Hu P.-C., Lucier T.S.,
RA Peterson S.N., Smith H.O., Hutchison C.A. III, Venter J.C.;
RT "The minimal gene complement of Mycoplasma genitalium.";
RL Science 270:397-403(1995).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 721-847.
RC STRAIN=ATCC 33530 / DSM 19775 / NCTC 10195 / G37;
RX PubMed=8253680; DOI=10.1128/jb.175.24.7918-7930.1993;
RA Peterson S.N., Hu P.-C., Bott K.F., Hutchison C.A. III;
RT "A survey of the Mycoplasma genitalium genome by using random sequencing.";
RL J. Bacteriol. 175:7918-7930(1993).
CC -!- FUNCTION: Component of the cytoskeleton-like structure which stabilizes
CC the shape of the wall-less Mycoplasma. This cytoskeleton-like network
CC of accessory proteins containing HMW proteins 1 to 5 allows the proper
CC anchoring of cytadhesin proteins in the mycoplasmal membrane at the
CC attachment organelle (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cell projection, attachment organelle membrane
CC {ECO:0000250}. Note=Localizes specifically to the attachment membrane.
CC {ECO:0000250}.
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DR EMBL; L43967; AAC71534.1; -; Genomic_DNA.
DR EMBL; U02261; AAD12527.1; -; Genomic_DNA.
DR PIR; E64234; E64234.
DR RefSeq; WP_010869424.1; NC_000908.2.
DR AlphaFoldDB; Q49413; -.
DR SMR; Q49413; -.
DR STRING; 243273.MG_312; -.
DR PRIDE; Q49413; -.
DR EnsemblBacteria; AAC71534; AAC71534; MG_312.
DR KEGG; mge:MG_312; -.
DR eggNOG; COG3115; Bacteria.
DR HOGENOM; CLU_296444_0_0_14; -.
DR OMA; PYGDTEY; -.
DR OrthoDB; 2073552at2; -.
DR BioCyc; MGEN243273:G1GJ2-381-MON; -.
DR Proteomes; UP000000807; Chromosome.
DR GO; GO:0033111; C:attachment organelle membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0042995; C:cell projection; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR GO; GO:0020035; P:adhesion of symbiont to microvasculature; IEA:UniProtKB-KW.
DR Gene3D; 3.30.70.3600; -; 1.
DR InterPro; IPR021199; Cytadherence_HMW-1_N.
DR InterPro; IPR022466; EAGR_box.
DR InterPro; IPR038145; EAGR_sf.
DR Pfam; PF16713; EAGR_box; 1.
DR TIGRFAMs; TIGR03834; EAGR_box; 1.
DR TIGRFAMs; TIGR03836; termin_org_HMW1; 1.
PE 3: Inferred from homology;
KW Cell membrane; Cell projection; Coiled coil; Cytadherence; Membrane;
KW Reference proteome; Virulence.
FT CHAIN 1..1139
FT /note="Cytadherence high molecular weight protein 1"
FT /id="PRO_0000084011"
FT REGION 128..266
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 369..570
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 902..935
FT /evidence="ECO:0000255"
FT COILED 974..1025
FT /evidence="ECO:0000255"
FT COMPBIAS 242..265
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 376..426
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 427..441
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 444..462
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 469..484
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 546..569
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1139 AA; 130531 MW; 0011D3288C3DD856 CRC64;
MAKNKQSVFE EKNYTQTEPE NIFGDLYDGK STVEEDPNIK VAYDADGNGY YIAFNKETGV
YYDPYGDTEY DISQLFDENG NPFVFDEKQE ENDYLKYVGN PDYGSYDENG EWVWSGYFEN
DQWISTKESQ PTDENYGFDS DLPPEVKQPE SVEDNYGFDN DLPPEVKQPE SVEDNYGFDN
DLPPEVKQPE SVVDQPSSDD YFAKQPTDEN YGFDNDLPPE VKQPESVVDQ PSSDDHFAKQ
PESTTDSYSF DSDLPQPTLD QPSLDDHVQY NFDHHEELKP VAEEQNNYQV GFDQVQANLD
NNEEIQPTAE KKVTTDFESK QAQVVDSYQL PIDTDQQDQT TFSSSFETQP TVEQFDQVNS
EVNDQFKPEI TKEPVLESSF NKQDVVETSD LNSESNLYSE NNKDATNNDS LNSEFIQLNS
NSETASDDVH YESKSEPIHD YKFGSDLSQS NSNNSLESEP VKFNSETAPD AHFESQSEPV
DQVQYDIYQN EELKPTLDQP SSDDYFAKQP TDENYGFDND LPPEVKQPES VVDQPSSDDH
FAKQPESTTD SYSFDSDLPQ PTLDQPSLDD HVQYNFDHHE ELKPVAEEQN NYQVGFDQVQ
ANLDNNEEIQ PTAEKEVTTD FESKQAQVVD SYQLPIDTDQ QDQTTFSSSF ETQPTVEQFD
QVNSEVNDQF KPEITKEPVL ESSFNKQDVV ETSNYTNNLQ KFDIQSDNKI TITTKKSSPQ
IPTTLPISFV SNRIEYKPVE TLALDNKESQ QEQITINSIT EDSKTLAKTL SVQLQQINSL
NNQSIVTSES VRLDKKDDQL TINTVNSEDQ QPKIEVFVKA KEPVEEHSIT QNKQSVEDKS
ELDNFNKKSD LYKIISELKR GELNPTINFD AIFQMNDYQM SVKQSFIHLN DFVTNYKNQI
SERYLIIKKE LQSELSRLID QNENLNVQFN NAKNLTTLQK EEMIRSLASD FAIAYKPSNS
YEQLQKSGEI MRHVQRAITE NEKKIESIQG SLKQLKTVYN SCCETIMNNI NKLDNTLRFA
KKEKDPLLLS NFDSVTDNGL VEPNQLMDDL IDFSNTFDNI SNEQLDDFIY ENMDRNIDFE
FEGFNNDFVD IDAKVMDSMS AFSVNDLDIE TLVPDRTSNF SSLLDEDLFE SSGDFSLDY
