HMW1_MYCPN
ID HMW1_MYCPN Reviewed; 1018 AA.
AC Q50365; Q50348; Q50349; Q9R5R4;
DT 01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1996, sequence version 1.
DT 03-AUG-2022, entry version 100.
DE RecName: Full=Cytadherence high molecular weight protein 1;
DE AltName: Full=Cytadherence accessory protein 1;
GN Name=hmw1; OrderedLocusNames=MPN_447; ORFNames=MP394;
OS Mycoplasma pneumoniae (strain ATCC 29342 / M129) (Mycoplasmoides
OS pneumoniae).
OC Bacteria; Tenericutes; Mollicutes; Mycoplasmataceae; Mycoplasma.
OX NCBI_TaxID=272634;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND PROTEIN SEQUENCE OF 1-16.
RC STRAIN=ATCC 29342 / M129;
RX PubMed=8675025; DOI=10.1016/0378-1119(96)00050-9;
RA Dirksen L.B., Proft T., Hilbert H., Plagens H., Herrmann R., Krause D.C.;
RT "Sequence analysis and characterization of the hmw gene cluster of
RT Mycoplasma pneumoniae.";
RL Gene 171:19-25(1996).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 29342 / M129;
RX PubMed=8948633; DOI=10.1093/nar/24.22.4420;
RA Himmelreich R., Hilbert H., Plagens H., Pirkl E., Li B.-C., Herrmann R.;
RT "Complete sequence analysis of the genome of the bacterium Mycoplasma
RT pneumoniae.";
RL Nucleic Acids Res. 24:4420-4449(1996).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 127-180.
RC STRAIN=ATCC 29342 / M129;
RX PubMed=7984111; DOI=10.1111/j.1365-2958.1994.tb00427.x;
RA Proft T., Herrmann R.;
RT "Identification and characterization of hitherto unknown Mycoplasma
RT pneumoniae proteins.";
RL Mol. Microbiol. 13:337-348(1994).
RN [4]
RP PROTEIN SEQUENCE OF 176-182 AND 188-198.
RX PubMed=1743522; DOI=10.1016/0378-1119(91)90300-z;
RA Krause D.C., Lee K.K.;
RT "Juxtaposition of the genes encoding Mycoplasma pneumoniae cytadherence-
RT accessory proteins HMW1 and HMW3.";
RL Gene 107:83-89(1991).
RN [5]
RP PHOSPHORYLATION.
RX PubMed=7635846; DOI=10.1128/jb.177.15.4571-4574.1995;
RA Krebes K.A., Dirksen L.B., Krause D.C.;
RT "Phosphorylation of Mycoplasma pneumoniae cytadherence-accessory proteins
RT in cell extracts.";
RL J. Bacteriol. 177:4571-4574(1995).
CC -!- FUNCTION: Component of the cytoskeleton-like structure which stabilizes
CC the shape of the wall-less Mycoplasma. This cytoskeleton-like network
CC of accessory proteins containing HMW proteins 1 to 5 allows the proper
CC anchoring of cytadhesin proteins in the mycoplasmal membrane at the
CC attachment organelle (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cell projection, attachment organelle membrane.
CC Note=Localizes specifically to the attachment membrane.
CC -!- PTM: Phosphorylated mainly on serine residues.
CC {ECO:0000269|PubMed:7635846}.
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DR EMBL; L38997; AAA61697.1; -; Genomic_DNA.
DR EMBL; U00089; AAB96042.1; -; Genomic_DNA.
DR EMBL; Z32661; CAA83580.1; -; Genomic_DNA.
DR EMBL; Z32662; CAA83581.1; -; Genomic_DNA.
DR PIR; S73720; S73720.
DR RefSeq; NP_110135.1; NC_000912.1.
DR RefSeq; WP_010874803.1; NC_000912.1.
DR AlphaFoldDB; Q50365; -.
DR SMR; Q50365; -.
DR IntAct; Q50365; 1.
DR STRING; 272634.MPN_447; -.
DR EnsemblBacteria; AAB96042; AAB96042; MPN_447.
DR KEGG; mpn:MPN_447; -.
DR PATRIC; fig|272634.6.peg.483; -.
DR HOGENOM; CLU_296444_0_0_14; -.
DR OMA; PYGDTEY; -.
DR BioCyc; MPNE272634:G1GJ3-720-MON; -.
DR Proteomes; UP000000808; Chromosome.
DR GO; GO:0033111; C:attachment organelle membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0042995; C:cell projection; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR GO; GO:0020035; P:adhesion of symbiont to microvasculature; IEA:UniProtKB-KW.
DR Gene3D; 3.30.70.3600; -; 1.
DR InterPro; IPR021199; Cytadherence_HMW-1_N.
DR InterPro; IPR022466; EAGR_box.
DR InterPro; IPR038145; EAGR_sf.
DR Pfam; PF16713; EAGR_box; 1.
DR TIGRFAMs; TIGR03834; EAGR_box; 1.
DR TIGRFAMs; TIGR03836; termin_org_HMW1; 1.
PE 1: Evidence at protein level;
KW Cell membrane; Cell projection; Coiled coil; Cytadherence;
KW Direct protein sequencing; Membrane; Phosphoprotein; Reference proteome;
KW Virulence.
FT CHAIN 1..1018
FT /note="Cytadherence high molecular weight protein 1"
FT /id="PRO_0000084012"
FT COILED 782..815
FT /evidence="ECO:0000255"
FT COILED 849..880
FT /evidence="ECO:0000255"
FT CONFLICT 198
FT /note="E -> I (in Ref. 4; AA sequence)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 1018 AA; 112215 MW; 3C3DEB273F9ABDE7 CRC64;
MKKSKEAVFE DKDYTEENPE QIFGNLYDGK LTVQDGKVKI AYDGDGNGYY IAFNSETGVY
YDPYGDTEYD ISVLFDANGN SFVFADAPTV EVLAGEQEQT EAEPDYLQYV GNEAYGYYDE
AGEWVWSGYF EGDQWISTLP QTEAEEKQFG FEDNIETTPT ASEDFGLEAD VPAPEVAEPS
YEVQPEVAAE PVYDVQPEVA VEPVGETTAT VEPQAVEIQP EVVVEPIVES QLEQPVEVQA
EMVQPEVAVE PQLEVSLDPI GETAPILEQV EPQAVQTQPE IPAEQSAVEL QPEPVAEVQS
EMVQPEAAAE PVTEAQQTEP TPVVETIAEI TPQVVTEPVV AVVEHQPEAV AEPLPVEPAV
AGVSELIPTE QVQPEVVVES TPVAEVQSEM VQPEVAVEPI VEPQPEQPVE VQPEVITTPE
VASVLEVQPE NPVVEVEQVV EPQPETPVEV QPEPVVETVQ EAVAEPTQVV EPQPQAAPQP
AVYEWNLTPE AAPVEQPEVI PVTVVESQAT ATAEPQPAVA PVADMDYVLH LTDTVKNQPQ
TAPVQPTTPI KIEVAESTPT VTTSPVEPTI APPLFEIELN NTTSSDLPLV EVVDFKHNQH
GAVGTHSFDD FTPPEVGMES KTHCHSNSEV VWRVSEPKTV PVPPAVSSIN IQTVNRVVEP
TISTPTTPVV ESAPAIEIFV DTPPVETKEA SSNVDVVQQP VKPLMPVMVE QLRTTELQPT
TEINLFANSD INSIIAELKQ GRSNPAINFD DIFKMSSYQM VVKKSFVQIS DFITNSKTDI
TNRFLLIKKE LQAELTRLIE ENEQLKAEFL NAKDLSVYQK DELLRSLSND FTIAHRPSDS
YEQLQKSGEL VRNIQKAILE NESKIKNIQI TLKELKAVYK LCSDTVLNGM AKLDSVLRFN
KKEKDPLLLN SMETLSSFET EPQAIIEDLL DFSSSFDKMS NEQLDEFVYQ NLDSGLNLDL
DGFDHQLSSM NIHGLEPLDP MKLDDFDFET LTPDKTSNLS SILDDELMEN GGDFNLDY
