ID   HMW2_MYCGA              Reviewed;        1931 AA.
AC   Q7NBF8;
DT   28-JUL-2009, integrated into UniProtKB/Swiss-Prot.
DT   15-DEC-2003, sequence version 1.
DT   03-AUG-2022, entry version 83.
DE   RecName: Full=Cytadherence high molecular weight protein 2;
DE   AltName: Full=Cytadherence accessory protein 2;
GN   Name=hlp2; Synonyms=hmw2; OrderedLocusNames=MYCGA3210; ORFNames=MGA_1203;
OS   Mycoplasma gallisepticum (strain R(low / passage 15 / clone 2))
OS   (Mycoplasmoides gallisepticum).
OC   Bacteria; Tenericutes; Mollicutes; Mycoplasmataceae; Mycoplasma.
OX   NCBI_TaxID=710127;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=R(low / passage 15 / clone 2);
RX   PubMed=12949158; DOI=10.1099/mic.0.26427-0;
RA   Papazisi L., Gorton T.S., Kutish G., Markham P.F., Browning G.F.,
RA   Nguyen D.K., Swartzell S., Madan A., Mahairas G., Geary S.J.;
RT   "The complete genome sequence of the avian pathogen Mycoplasma
RT   gallisepticum strain R(low).";
RL   Microbiology 149:2307-2316(2003).
CC   -!- FUNCTION: Component of the cytoskeleton-like structure which stabilizes
CC       the shape of the wall-less Mycoplasma. This cytoskeleton-like network
CC       of accessory proteins containing HMW proteins 1 to 5 allows the proper
CC       anchoring of cytadhesin proteins in the mycoplasmal membrane at the
CC       attachment organelle (By similarity). {ECO:0000250}.
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DR   EMBL; AE015450; AAP56671.1; -; Genomic_DNA.
DR   RefSeq; WP_011113563.1; NC_004829.2.
DR   AlphaFoldDB; Q7NBF8; -.
DR   SMR; Q7NBF8; -.
DR   PRIDE; Q7NBF8; -.
DR   KEGG; mga:MGA_1203; -.
DR   PATRIC; fig|233150.7.peg.357; -.
DR   HOGENOM; CLU_235185_0_0_14; -.
DR   OMA; DEFRNQG; -.
DR   OrthoDB; 1963013at2; -.
DR   Proteomes; UP000001418; Chromosome.
DR   GO; GO:0020035; P:adhesion of symbiont to microvasculature; IEA:UniProtKB-KW.
DR   InterPro; IPR016430; Cytadherence_Hmw2.
DR   PIRSF; PIRSF004800; Hmw2; 1.
PE   3: Inferred from homology;
KW   Coiled coil; Cytadherence; Reference proteome; Virulence.
FT   CHAIN           1..1931
FT                   /note="Cytadherence high molecular weight protein 2"
FT                   /id="PRO_0000380120"
FT   COILED          1626..1659
FT                   /evidence="ECO:0000255"
FT   COILED          1768..1846
FT                   /evidence="ECO:0000255"
FT   COILED          1903..1930
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   1931 AA;  229935 MW;  51330EDBCC555351 CRC64;
     MQKDYMKLHS NSDFDADQLD EHDDNVFQDV YDTGFDDGYI KANQENLIAN QYKKLDKNSY
     QNGNNSFYTK DELEKLKKQS FQVNQDIDYY QQAQTEISSE RQRLLQAIDD LEANQDQFHP
     EDFQAERQYL INELDRLDSE LYHIEQYKND SIDFVNELNQ RLSAEQAKID SYNSSLDKNI
     RKDYIQIDQL KNKLAEETTE YNDLLNRSTD EISEIDRQSE RLQNLIDERI AKLNNDSYGV
     SSLDSSTRER LKKEIHDLSE QRKKLQSAKK LHLYNLNLKK ESIRRYRSQL EQYLESLKQM
     RNEHNKKLKG YAQNLDNIKN EVEKAKQNFN DQQLKILQSK ANADQYFALR KIELENSYKK
     AKNAILEANK AHAKNVQEEQ ALANKNNKTQ RLLNKLKEDY DRLKIASLSF ESMRKQSLAA
     LNNLQDELKQ KHNLLERKKH EQDGIVNEKI SELEGYRSDL VDQKLKIERE KENQERRYKA
     AEASLNKKRQ EIDELFLEAN TKLNEASLKE NDLNNQKREI LAKLRNLEHL KSEIDQRRRD
     LDQRELIDQQ TIRKIQLDVE SERADLQRIL LIERKKNDER QQELLQYERD IKRQQTDFEN
     TVNWEQKKLS QREKELKDGY EQLQLKQSEV QEKIDELNEE INRAQKSKQN SLVLEQKLKS
     DLEHLNLSKN YLDKQQEELN QKSDKMIEDL KVFERDLKRQ KEDLSIYEKS LQQKEASLIN
     FQNDVTVQKN EAYHKAQAIH QELELKKAAI ENELRKLTAE RKAVDADKEE NTKLKKFIDE
     EIRSLANERK ELEIYQNNIE NFKNNAVDRL NVLESDLVKK RNELEQLKKE QQTHYNELNS
     NLTNELQELE EQKKKFAHQK QQKFEELLQA KNNLSIKENE LVLYAQKVND RYNELKAIEK
     SNTAKSEMIN AKLEEFKHAE IDYLNYQNKI KQEQIKFDNQ VKILESQYNQ RNEILLIREE
     QIKQKKAEQQ AQEKQIQKDF KRLQEEKNNF DDQKRNKFNK ISNLYLEIKK QRDEVDLAQR
     QIEDQKEELL IKAREGRLQK QEIEDRLAVL EKSEKRFRQE DELLAKKRID LIERIGVLKA
     DINKKHEILS LRSVQLTEKA KKQQEKDADL QRKFDLLESE VERFNEEKKS EFQKLKVERD
     KLAHREKNVS KNMNEINLAL AKLDLIRKNN KVDKAKINEK LALLNDQKEK IDRENDLLDA
     KKTEVITRLR KMENDLEFEK QKVLLDRSNI ERISSDQQAL ARELETKYQT LEREKRSFSQ
     RKENELKEID DFYQQVQHKE RTLNLKIEDL KQLRYLLEKE SYNVNVNKKD LKVRIEHYQR
     LERAIKNEQH KLNNQKNNFF NKVELLNDQL NKKSSKIALL RSKIYNTYKQ QQQQKQILLE
     EKHKNSQLRK SLLKTQEELH QQKAQFSIAK KQEEKKLKNQ KDLIQNTLSE VIKQKDQITN
     IKQEVDLKQT QLNNLEKLII KQRADLQKEL EKNSENTYRL QKAERLLEEK KTKLRLEYDK
     AKKVLSTAKA TDQALKTKQA KVQDQFKKLV LINKKIIEAR NNLLKQRNII QKEINNRNMA
     NFQNPYPNFL NLAPNTQVVP AQTIMPVQTP QLVGVNYPNQ PAFDFNNPLM QMQQLINQQQ
     MLMMQKEHQW ALEEANKKNS RLAKQLKQLK HHKQALTEST SEHLNYHNLL NADNSYKINS
     LQNLLSKVAY NTKRRINQLE HNLDPETADL NQLHELNANS QLLDEIRTVL SNTTTNTNAV
     VPANSYSKEL RMLFDEIKAD FKKQAVLFNT QKEVFTNQIN QLAQAVEQGP IEVRKTLESQ
     DQKYQQMFDN FRDAYEQNIS LLRNENNEVQ KKLTDLYDEI AAIKTNTEKI KKTTLRPEVR
     NNANEGLASF NSVNRDKKDY LDQTLPVHQN LRIDLNQNRD LSHAKKERIN QLANEIKTIK
     ELIEKRKQTS L