ID   HMW2_MYCGE              Reviewed;        1805 AA.
AC   P47460;
DT   01-FEB-1996, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1996, sequence version 1.
DT   03-AUG-2022, entry version 104.
DE   RecName: Full=Cytadherence high molecular weight protein 2;
DE   AltName: Full=Cytadherence accessory protein 2;
GN   Name=hmw2; OrderedLocusNames=MG218;
OS   Mycoplasma genitalium (strain ATCC 33530 / DSM 19775 / NCTC 10195 / G37)
OS   (Mycoplasmoides genitalium).
OC   Bacteria; Tenericutes; Mollicutes; Mycoplasmataceae; Mycoplasma.
OX   NCBI_TaxID=243273;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 33530 / DSM 19775 / NCTC 10195 / G37;
RX   PubMed=7569993; DOI=10.1126/science.270.5235.397;
RA   Fraser C.M., Gocayne J.D., White O., Adams M.D., Clayton R.A.,
RA   Fleischmann R.D., Bult C.J., Kerlavage A.R., Sutton G.G., Kelley J.M.,
RA   Fritchman J.L., Weidman J.F., Small K.V., Sandusky M., Fuhrmann J.L.,
RA   Nguyen D.T., Utterback T.R., Saudek D.M., Phillips C.A., Merrick J.M.,
RA   Tomb J.-F., Dougherty B.A., Bott K.F., Hu P.-C., Lucier T.S.,
RA   Peterson S.N., Smith H.O., Hutchison C.A. III, Venter J.C.;
RT   "The minimal gene complement of Mycoplasma genitalium.";
RL   Science 270:397-403(1995).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 557-659.
RC   STRAIN=ATCC 33530 / DSM 19775 / NCTC 10195 / G37;
RX   PubMed=8253680; DOI=10.1128/jb.175.24.7918-7930.1993;
RA   Peterson S.N., Hu P.-C., Bott K.F., Hutchison C.A. III;
RT   "A survey of the Mycoplasma genitalium genome by using random sequencing.";
RL   J. Bacteriol. 175:7918-7930(1993).
CC   -!- FUNCTION: Component of the cytoskeleton-like structure which stabilizes
CC       the shape of the wall-less Mycoplasma. This cytoskeleton-like network
CC       of accessory proteins containing HMW proteins 1 to 5 allows the proper
CC       anchoring of cytadhesin proteins in the mycoplasmal membrane at the
CC       attachment organelle (By similarity). {ECO:0000250}.
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DR   EMBL; L43967; AAC71437.1; -; Genomic_DNA.
DR   EMBL; U02165; AAD12447.1; -; Genomic_DNA.
DR   PIR; A64224; A64224.
DR   RefSeq; WP_010869377.1; NC_000908.2.
DR   AlphaFoldDB; P47460; -.
DR   SMR; P47460; -.
DR   STRING; 243273.MG_218; -.
DR   PRIDE; P47460; -.
DR   EnsemblBacteria; AAC71437; AAC71437; MG_218.
DR   KEGG; mge:MG_218; -.
DR   eggNOG; COG0419; Bacteria.
DR   eggNOG; COG1196; Bacteria.
DR   HOGENOM; CLU_237675_0_0_14; -.
DR   OMA; KHDRQQA; -.
DR   OrthoDB; 1963013at2; -.
DR   BioCyc; MGEN243273:G1GJ2-262-MON; -.
DR   Proteomes; UP000000807; Chromosome.
DR   GO; GO:0020035; P:adhesion of symbiont to microvasculature; IEA:UniProtKB-KW.
DR   InterPro; IPR016430; Cytadherence_Hmw2.
DR   PIRSF; PIRSF004800; Hmw2; 1.
PE   3: Inferred from homology;
KW   Coiled coil; Cytadherence; Reference proteome; Virulence.
FT   CHAIN           1..1805
FT                   /note="Cytadherence high molecular weight protein 2"
FT                   /id="PRO_0000084013"
FT   COILED          28..838
FT                   /evidence="ECO:0000255"
FT   COILED          914..1591
FT                   /evidence="ECO:0000255"
FT   COILED          1632..1723
FT                   /evidence="ECO:0000255"
FT   COILED          1777..1804
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   1805 AA;  216253 MW;  11D093AF173284FD CRC64;
     MKPFDKKPSL QPIYDIGFDD GYLQSEYEKN RSKTDVDKIE NQLLKEIKSL EDELKNLKGL
     KNQAEDNPEL DKKINHLEVD LNRLVNEYKN FQFQKNHMVD KVSELDNLTR FYKNELTRLQ
     QENADFLNSK YANLANFQAN YHNKLNDFHR LIENQNQTIN RLNQKINGNQ NLIDNNVALL
     QNPNITVEKK NYLLNVIDQL YNELDQLENQ KRLLSIEYEN TYRELVSADN ELQNVYENID
     QNQIQFKHQY QTYRDELSQL ERKIQLTKQE LVDKESALRV KIDDADFYIN ARLAELDDVA
     KQLSFQDGIT KQNAQHVEDK LVALNKEKDR LNTQKEAFFN LRQSALIDIN KLQQENELFA
     KHLEHQQNEF EQKQSDSLLK LETEYKALQH KINEFKNESA TKSEELLNQE RELFEKRREI
     DTLLTQASLE YEHQRESSQL LKDKQNEVKQ HFQNLEYAKK ELDKERNLLD QQKKVDSEAI
     FQLKEKVAQE RKELEELYLV KKQKQDQKEN ELLFFEKQLK QHQADFENEL EAKQQELFEA
     KHALERSFIK LEDKEKDLNT KAQQIANEFS QLKTDKSKSA DFELMLQNEY ENLQQEKQKL
     FQERTYFERN AAVLSNRLQQ KREELLQQKE TLDQLTKSFE QERLINQREH KELVASVEKQ
     KEILGKKLQD FSQTSLNASK NLAEREMAIK FKEKEIEATE KQLLNDVNNA EVIQADLAQL
     NQSLNQERSE LQNAKQRIAD FHNDSLKKLN EYELSLQKRL QELQTLEANQ KQHSYQNQAY
     FEGELDKLNR EKQAFLNLRK KQTMEVDAIK QRLSDKHQAL NMQQAELDRK THELNNAFLN
     HDADQKSLQD QLATVKETQK LIDLERSALL EKQREFAENV AGFKRHWSNK TSQLQKIYEL
     TKKQESEQTQ KETELKIAFS DLQKDYQVFE LQKDQEFRQI EAKQRELDKL AEKNNQVKLE
     LDNRFQALQN QKQDTVQAQL ELEREQHQLN LEQTAFNQAN ESLLKQREQL TKKIQAFHYE
     LKKRNQFLAL KGKRLFAKEQ DQQRKDQEIN WRFKQFEKEY TDFDEAKKRE LEELEKIRRS
     LSQSNVELER KREKLATDFT NLNKVQHNTQ INRDQLNSQI RQFLLERKNF QRFSNEANAK
     KAFLIKRLRS FASNLKLQKE ALAIQKLEFD KRDEQQKKEL QQATLQLEQF KFEKQNFDIE
     KQRQLVAIKT QCEKLSDEKK ALNQKLVELK NLSQTYLANK NKAEYSQQQL QQKYTNLLDL
     KENLERTKDQ LDKKHRSIFA RLTKFANDLR FEKKQLLKAQ RIVDDKNRLL KENERNLHFL
     SNETERKRAV LEDQISYFEK QRKQATDAIL ASHKEVKKKE GELQKLLVEL ETRKTKLNND
     FAKFSRQREE FENQRLKLLE LQKTLQTQTN SNNFKTKAIQ EIENSYKRGM EELNFQKKEF
     DKNKSRLYEY FRKMRDEIER KESQVKLVLK ETQRKANLLE AQANKLNIEK NTIDFKEKEL
     KAFKDKVDQD IDSTNKQRKE LNELLNENKL LQQSLIERER AINSKDSLLN KKIETIKRQL
     HDKEMRVLRL VDRMKLAEQK YQTEINRLRT QTFDSEKQDI KNFFPPLFKI NGNDMAFPYL
     YPWLYPQQKQ DDNTLQIRQL FEQQLQFMQQ RYENELNELR RQRNLLEKKL DQIQLESQLN
     NKQSEFSKVE SMMEKLLEKT ESRLNDFDQK INYLTKKVNQ HNTYQPSSYQ PTPSYQDSDK
     QQLLFRIQEL EKQNLFQQQF QPAPAVVQQP TSFAAPNITK QQQIAQLNAE INNIKRLIAQ
     KAASK