HMW3_MYCGE
ID HMW3_MYCGE Reviewed; 599 AA.
AC Q57081; Q49191; Q49337; Q49370;
DT 01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1996, sequence version 1.
DT 03-AUG-2022, entry version 99.
DE RecName: Full=Cytadherence high molecular weight protein 3;
DE AltName: Full=Accessory adhesin protein 3;
DE AltName: Full=Cytadherence accessory protein 3;
DE AltName: Full=P69;
GN Name=hmw3; OrderedLocusNames=MG317;
OS Mycoplasma genitalium (strain ATCC 33530 / DSM 19775 / NCTC 10195 / G37)
OS (Mycoplasmoides genitalium).
OC Bacteria; Tenericutes; Mollicutes; Mycoplasmataceae; Mycoplasma.
OX NCBI_TaxID=243273;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=ATCC 33530 / DSM 19775 / NCTC 10195 / G37;
RX PubMed=7592348; DOI=10.1128/jb.177.20.5943-5951.1995;
RA Reddy S.P., Rasmussen W.G., Baseman J.B.;
RT "Molecular cloning and characterization of an adherence-related operon of
RT Mycoplasma genitalium.";
RL J. Bacteriol. 177:5943-5951(1995).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 33530 / DSM 19775 / NCTC 10195 / G37;
RX PubMed=7569993; DOI=10.1126/science.270.5235.397;
RA Fraser C.M., Gocayne J.D., White O., Adams M.D., Clayton R.A.,
RA Fleischmann R.D., Bult C.J., Kerlavage A.R., Sutton G.G., Kelley J.M.,
RA Fritchman J.L., Weidman J.F., Small K.V., Sandusky M., Fuhrmann J.L.,
RA Nguyen D.T., Utterback T.R., Saudek D.M., Phillips C.A., Merrick J.M.,
RA Tomb J.-F., Dougherty B.A., Bott K.F., Hu P.-C., Lucier T.S.,
RA Peterson S.N., Smith H.O., Hutchison C.A. III, Venter J.C.;
RT "The minimal gene complement of Mycoplasma genitalium.";
RL Science 270:397-403(1995).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-24; 57-169 AND 444-514.
RC STRAIN=ATCC 33530 / DSM 19775 / NCTC 10195 / G37;
RX PubMed=8253680; DOI=10.1128/jb.175.24.7918-7930.1993;
RA Peterson S.N., Hu P.-C., Bott K.F., Hutchison C.A. III;
RT "A survey of the Mycoplasma genitalium genome by using random sequencing.";
RL J. Bacteriol. 175:7918-7930(1993).
CC -!- FUNCTION: Component of the cytoskeleton-like structure which stabilizes
CC the shape of the wall-less mycoplasma. This cytoskeleton-like network
CC of accessory proteins containing HMW proteins 1 to 5 allows the proper
CC anchoring of cytadhesin proteins in the mycoplasmal membrane at the
CC attachment organelle. Essential for successful surface parasitism (By
CC similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cell projection, attachment organelle membrane
CC {ECO:0000250}. Note=Localizes specifically to the attachment membrane.
CC {ECO:0000250}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAC43190.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; L43967; AAC71539.1; -; Genomic_DNA.
DR EMBL; L43097; AAA99946.1; -; Genomic_DNA.
DR EMBL; U01716; AAC43190.1; ALT_INIT; Unassigned_DNA.
DR EMBL; U02224; AAA03378.1; -; Genomic_DNA.
DR EMBL; U02267; AAD12533.1; -; Genomic_DNA.
DR PIR; A64235; A64235.
DR RefSeq; WP_010869426.1; NC_000908.2.
DR AlphaFoldDB; Q57081; -.
DR SMR; Q57081; -.
DR STRING; 243273.MG_317; -.
DR EnsemblBacteria; AAC71539; AAC71539; MG_317.
DR KEGG; mge:MG_317; -.
DR eggNOG; COG3115; Bacteria.
DR HOGENOM; CLU_455483_0_0_14; -.
DR OMA; PHERYQL; -.
DR OrthoDB; 2132296at2; -.
DR BioCyc; MGEN243273:G1GJ2-386-MON; -.
DR Proteomes; UP000000807; Chromosome.
DR GO; GO:0033111; C:attachment organelle membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0042995; C:cell projection; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR GO; GO:0020035; P:adhesion of symbiont to microvasculature; IEA:UniProtKB-KW.
PE 3: Inferred from homology;
KW Cell membrane; Cell projection; Cytadherence; Membrane; Reference proteome;
KW Virulence.
FT CHAIN 1..599
FT /note="Cytadherence high molecular weight protein 3"
FT /id="PRO_0000084015"
FT REGION 220..241
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 220..239
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 599 AA; 68721 MW; D786BE7BD491129A CRC64;
MNDKQKAKIN KAYNKLLKKI NKRYPDVSVV YARDHKNKVH ALYQDPESGN IFSLEKRKQL
ASNYPLFELT SDNPISFTNN IVSLNAYDDK NNLVTVQYDQ DNNTFYDQNG NVLDVSSYTD
EKKVPLINYL SSTQTSQEQP TQQDYPSIDA GLPKIEVDDQ PKAAQHTTLE TESEPDVFEL
NDSLNQPQQP TENLGDDQFV EKEVPPTQQL HQDLVHQQPV QVDSGSQNHS FNNSPSLKPP
LVNKPAKLVQ PEVKHIPQVE VQPKPQIVEP KIEPKPEVKH VSHVEIQPKP EVKPVVDSVP
EVKQPEVKHV PHVEVQPKPV VDLKPQRIEP RIESKPEVIK HIPQVEVQPK AQMVEPRIEP
KPETKYIPQV ESTPQVEVHH WKPEVKTEYQ PQQPLPTSGL QIKVVPRSAA LLQSKLDTGF
QPRQVERTTD SDITVSVSSH ASLLEKINAL NHQRIMSDIA LKSDNTIKSS NFSRFYPENE
YVATKYSDPL YSDTNQSLTS DRFSLDFDYT PKSRVNNYTP LRSTNFQNNA ISNYRFSRTP
SSYYPLTRRP WRLTNISSYR SSFHSPTRLS SFRRTSLPFS SSYDGLRRYP SRSYWSKDF
