HMW3_MYCPN
ID HMW3_MYCPN Reviewed; 672 AA.
AC Q50360;
DT 01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1996, sequence version 1.
DT 03-AUG-2022, entry version 98.
DE RecName: Full=Cytadherence high molecular weight protein 3;
DE AltName: Full=Accessory adhesin protein 3;
DE AltName: Full=Cytadherence accessory protein 3;
GN Name=hmw3; OrderedLocusNames=MPN_452; ORFNames=MP389;
OS Mycoplasma pneumoniae (strain ATCC 29342 / M129) (Mycoplasmoides
OS pneumoniae).
OC Bacteria; Tenericutes; Mollicutes; Mycoplasmataceae; Mycoplasma.
OX NCBI_TaxID=272634;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND PROTEIN SEQUENCE OF 1-29.
RC STRAIN=ATCC 29342 / M129-B17;
RX PubMed=1548085; DOI=10.1128/iai.60.4.1633-1641.1992;
RA Ogle K.F., Lee K.K., Krause D.C.;
RT "Nucleotide sequence analysis reveals novel features of the phase-variable
RT cytadherence accessory protein HMW3 of Mycoplasma pneumoniae.";
RL Infect. Immun. 60:1633-1641(1992).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 29342 / M129;
RX PubMed=8948633; DOI=10.1093/nar/24.22.4420;
RA Himmelreich R., Hilbert H., Plagens H., Pirkl E., Li B.-C., Herrmann R.;
RT "Complete sequence analysis of the genome of the bacterium Mycoplasma
RT pneumoniae.";
RL Nucleic Acids Res. 24:4420-4449(1996).
RN [3]
RP PROTEIN SEQUENCE OF 279-290.
RC STRAIN=ATCC 29342 / M129-B17;
RX PubMed=1899847; DOI=10.1016/0378-1119(91)90011-y;
RA Ogle K.F., Lee K.K., Krause D.C.;
RT "Cloning and analysis of the gene encoding the cytadherence phase-variable
RT protein HMW3 from Mycoplasma pneumoniae.";
RL Gene 97:69-75(1991).
CC -!- FUNCTION: Component of the cytoskeleton-like structure which stabilizes
CC the shape of the wall-less mycoplasma. This cytoskeleton-like network
CC of accessory proteins containing HMW proteins 1 to 5 allows the proper
CC anchoring of cytadhesin proteins in the mycoplasmal membrane at the
CC attachment organelle. Essential for successful surface parasitism.
CC -!- SUBCELLULAR LOCATION: Cell projection, attachment organelle membrane.
CC Note=Localizes specifically to the attachment membrane.
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DR EMBL; L38997; AAA61692.1; -; Genomic_DNA.
DR EMBL; U00089; AAB96037.1; -; Genomic_DNA.
DR PIR; S73715; S73715.
DR RefSeq; NP_110140.1; NC_000912.1.
DR RefSeq; WP_010874808.1; NC_000912.1.
DR AlphaFoldDB; Q50360; -.
DR IntAct; Q50360; 3.
DR STRING; 272634.MPN_452; -.
DR PRIDE; Q50360; -.
DR EnsemblBacteria; AAB96037; AAB96037; MPN_452.
DR KEGG; mpn:MPN_452; -.
DR PATRIC; fig|272634.6.peg.488; -.
DR HOGENOM; CLU_455483_0_0_14; -.
DR OMA; PHERYQL; -.
DR BioCyc; MPNE272634:G1GJ3-732-MON; -.
DR Proteomes; UP000000808; Chromosome.
DR GO; GO:0033111; C:attachment organelle membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0042995; C:cell projection; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR GO; GO:0020035; P:adhesion of symbiont to microvasculature; IEA:UniProtKB-KW.
PE 1: Evidence at protein level;
KW Cell membrane; Cell projection; Cytadherence; Direct protein sequencing;
KW Membrane; Reference proteome; Repeat; Virulence.
FT CHAIN 1..672
FT /note="Cytadherence high molecular weight protein 3"
FT /id="PRO_0000084016"
FT REPEAT 98..100
FT /note="1-1"
FT REPEAT 106..108
FT /note="1-2"
FT REPEAT 160..162
FT /note="2-1"
FT REPEAT 197..199
FT /note="1-3"
FT REPEAT 206..208
FT /note="1-4"
FT REPEAT 211..213
FT /note="1-5"
FT REPEAT 221..223
FT /note="1-6"
FT REPEAT 226..228
FT /note="1-7"
FT REPEAT 235..237
FT /note="1-8"
FT REPEAT 249..251
FT /note="1-9"
FT REPEAT 288..290
FT /note="2-2"
FT REPEAT 310..319
FT /note="3-1"
FT REPEAT 312..315
FT /note="4-1"
FT REPEAT 316..318
FT /note="2-3"
FT REPEAT 322..324
FT /note="2-4"
FT REPEAT 330..339
FT /note="3-2"
FT REPEAT 332..335
FT /note="4-2"
FT REPEAT 336..338
FT /note="2-5"
FT REPEAT 354..358
FT /note="4-3"
FT REPEAT 385..389
FT /note="4-4"
FT REPEAT 396..400
FT /note="4-5"
FT REPEAT 402..404
FT /note="2-6"
FT REPEAT 413..415
FT /note="2-7"
FT REPEAT 424..428
FT /note="4-6"
FT REPEAT 454..456
FT /note="2-8"
FT REGION 98..251
FT /note="9 X 3 AA repeats OF Y-D-Q"
FT REGION 160..456
FT /note="8 X 3 AA repeats of P-V-V"
FT REGION 177..197
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 310..339
FT /note="2 X 10 AA repeats of V-E-P-T-P-T-P-V-V-E"
FT REGION 312..428
FT /note="6 X 5 AA repeats of P-X-P-X-P"
FT CONFLICT 288
FT /note="P -> R (in Ref. 3; AA sequence)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 672 AA; 73721 MW; 1FD2345F5850777D CRC64;
MTDKERAKLA KAYGKLAQKI QKSYPDINVV YGRDAKNKLH ALYQDPETGN IFSLEKRKQL
PADYPLFELD SDEPISFAPK IIPLTAFDGN NNEVIVQYDQ VNNTFYDQDG NVLDVSGYRD
GENIPLVDYL NYGGSTASAD TTTSEPLSGE GYPDIDAGLP VVDPDATPEQ QADQLFGLDP
LPQAPDEYQD TTAPPAYDQT FDQATYDQQA YDQNYDPNAY YDQQAYDQSF DQQAYDQAYD
ANAYNTQNYD QAHDPNAYYD SQAYSDPDQA SAVAPIEVAP LQPEPVAPVV EPTAVPIVES
APIVEVTPTV EPTPTPVVET APVVEAPKVV EPTPTPVVEA TPAPKVEPKV VEQPQPTPVT
VEVDSPKVEI PKVVTAKVAL QVAQPTPVPA VPKVAPQPTP APVVVQPTAV VQPVVKAEPK
VVTPTPAPQV VVTPQVATPK VTPKVVQTTP AVPPVVVQPE VVVQPIIRPT QPEPEWKPSP
ASVVEPQPCQ SACVNNESGA ITIHTTNRSL LLEKLASLGH LHDASTRTPL PHERYQLAPP
SEYVATKYNE PLFNLPAIRN SWARFTRPTV ESTPIASRFT GVTPMAVNYR NPASLNFDSL
NSFGAYRSPS SFYPLRRPLE LSSLRRNRSS FFNTHRFDLG SNYTSFTPRY RSPLRGGLSQ
RFPLRSSWSK EF
