ID   HMX1_CHICK              Reviewed;         333 AA.
AC   Q9DE09;
DT   20-FEB-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2001, sequence version 1.
DT   03-AUG-2022, entry version 120.
DE   RecName: Full=Homeobox protein HMX1;
DE   AltName: Full=GH6;
DE   AltName: Full=Homeobox protein H6;
GN   Name=HMX1; Synonyms=H6;
OS   Gallus gallus (Chicken).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC   Phasianinae; Gallus.
OX   NCBI_TaxID=9031;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, AND DEVELOPMENTAL STAGE.
RX   PubMed=11060230; DOI=10.1242/dev.127.23.5033;
RA   Schulte D., Cepko C.L.;
RT   "Two homeobox genes define the domain of EphA3 expression in the developing
RT   chick retina.";
RL   Development 127:5033-5045(2000).
CC   -!- FUNCTION: DNA-binding protein that binds to the 5'-CAAG-3' core
CC       sequence. May function as a transcriptional repressor. Seems to act as
CC       a transcriptional antagonist of NKX2-5. May play an important role in
CC       the development of craniofacial structures such as the eye and ear.
CC       {ECO:0000269|PubMed:11060230}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC   -!- DEVELOPMENTAL STAGE: At stage 11, expressed in the surface ectoderm
CC       surrounding the optic vesicle. At stage 15, expressed in anterior/nasal
CC       side of the early retina. At stage 26, during the peak period of
CC       ganglion cell genesis, highly expressed in the nasal retina and the
CC       lens ectoderm. {ECO:0000269|PubMed:11060230}.
CC   -!- SIMILARITY: Belongs to the HMX homeobox family. {ECO:0000305}.
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DR   EMBL; AF227921; AAG48561.1; -; mRNA.
DR   RefSeq; NP_990864.1; NM_205533.1.
DR   AlphaFoldDB; Q9DE09; -.
DR   SMR; Q9DE09; -.
DR   STRING; 9031.ENSGALP00000025107; -.
DR   GeneID; 396546; -.
DR   KEGG; gga:396546; -.
DR   CTD; 3166; -.
DR   VEuPathDB; HostDB:geneid_396546; -.
DR   eggNOG; KOG0485; Eukaryota.
DR   HOGENOM; CLU_064096_2_0_1; -.
DR   InParanoid; Q9DE09; -.
DR   OrthoDB; 1313583at2759; -.
DR   PRO; PR:Q9DE09; -.
DR   Proteomes; UP000000539; Unplaced.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0003677; F:DNA binding; IMP:UniProtKB.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR   GO; GO:0000977; F:RNA polymerase II transcription regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR   GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IMP:UniProtKB.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   CDD; cd00086; homeodomain; 1.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR017970; Homeobox_CS.
DR   InterPro; IPR001356; Homeobox_dom.
DR   InterPro; IPR020479; Homeobox_metazoa.
DR   Pfam; PF00046; Homeodomain; 1.
DR   PRINTS; PR00024; HOMEOBOX.
DR   SMART; SM00389; HOX; 1.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   PROSITE; PS00027; HOMEOBOX_1; 1.
DR   PROSITE; PS50071; HOMEOBOX_2; 1.
PE   2: Evidence at transcript level;
KW   Developmental protein; DNA-binding; Homeobox; Nucleus; Reference proteome;
KW   Repressor; Transcription; Transcription regulation.
FT   CHAIN           1..333
FT                   /note="Homeobox protein HMX1"
FT                   /id="PRO_0000278455"
FT   DNA_BIND        201..260
FT                   /note="Homeobox"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT   REGION          1..74
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          86..109
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          139..204
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOTIF           261..271
FT                   /note="HMX family specific domain 1"
FT   COMPBIAS        15..33
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        177..201
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   333 AA;  34897 MW;  4B0EB64904022B12 CRC64;
     MAQDRECLCS AGFQRGDYTQ GNTDRSTAAA NSRPPAGQRG AEEPSSGGAG TPPPAAVLPT
     MPDEATENAG STSARVSSFF IEDLLGTEGG GGTRRAAAGG GGGRGAPRCG PHSPLRLGAS
     GCPLRDAAVG WYRRAFLGCA SPDTSDRDSP ELPEDTERAG GGGRAAARGP AGGRQSSGGR
     EEEEERGEEA GEAEQRAAGR KKKTRTVFSR SQVFQLESTF DVKRYLSSSE RAGLAASLHL
     TETQVKIWFQ NRRNKWKRQL AADLEAANLS HAAQRIVRVP ILYHENSPAS ALGFGLPHMS
     PPLVGFSGGV SYPLGTFPAA SLPFLRSQMT GLV