HMX1_MOUSE
ID HMX1_MOUSE Reviewed; 332 AA.
AC O70218;
DT 20-FEB-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-AUG-1998, sequence version 1.
DT 03-AUG-2022, entry version 147.
DE RecName: Full=Homeobox protein HMX1;
DE AltName: Full=Homeobox protein H6;
GN Name=Hmx1; Synonyms=H6;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], FUNCTION, TISSUE SPECIFICITY, AND
RP DEVELOPMENTAL STAGE.
RC STRAIN=129/Sv;
RX PubMed=9628823; DOI=10.1006/geno.1998.5284;
RA Yoshiura K., Leysens N.J., Reiter R.S., Murray J.C.;
RT "Cloning, characterization, and mapping of the mouse homeobox gene Hmx1.";
RL Genomics 50:61-68(1998).
CC -!- FUNCTION: DNA-binding protein that binds to the 5'-CAAG-3' core
CC sequence. May function as a transcriptional repressor. Seems to act as
CC a transcriptional antagonist of NKX2-5. May play an important role in
CC the development of craniofacial structures such as the eye and ear.
CC {ECO:0000269|PubMed:9628823}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- TISSUE SPECIFICITY: Expressed in neural crest-derived tissues,
CC including, nerve ganglia and cranial mesenchyme.
CC {ECO:0000269|PubMed:9628823}.
CC -!- DEVELOPMENTAL STAGE: On 9.5 dpc expressed in the trigeminal (V)
CC ganglion. On 10.5-11 dpc, expressed in the eye, second branchial arch
CC and the dorsal root ganglion. On 11.5-12 dpc, expressed in the lens and
CC neural epithelium of the eye. On 14-16 dpc, expressed in the
CC sympathetic ganglon and dorso-lateral mesenchyme near the developing
CC ear. {ECO:0000269|PubMed:9628823}.
CC -!- SIMILARITY: Belongs to the HMX homeobox family. {ECO:0000305}.
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DR EMBL; AF009614; AAC24193.1; -; Genomic_DNA.
DR EMBL; AF009367; AAC24324.1; -; mRNA.
DR CCDS; CCDS19228.1; -.
DR RefSeq; NP_034575.1; NM_010445.2.
DR AlphaFoldDB; O70218; -.
DR SMR; O70218; -.
DR STRING; 10090.ENSMUSP00000084958; -.
DR iPTMnet; O70218; -.
DR PhosphoSitePlus; O70218; -.
DR PaxDb; O70218; -.
DR PRIDE; O70218; -.
DR ProteomicsDB; 273346; -.
DR Antibodypedia; 4687; 51 antibodies from 16 providers.
DR DNASU; 15371; -.
DR Ensembl; ENSMUST00000087674; ENSMUSP00000084958; ENSMUSG00000067438.
DR GeneID; 15371; -.
DR KEGG; mmu:15371; -.
DR UCSC; uc008xds.1; mouse.
DR CTD; 3166; -.
DR MGI; MGI:107178; Hmx1.
DR VEuPathDB; HostDB:ENSMUSG00000067438; -.
DR eggNOG; KOG0485; Eukaryota.
DR GeneTree; ENSGT00940000162580; -.
DR HOGENOM; CLU_064096_2_0_1; -.
DR InParanoid; O70218; -.
DR OMA; TMEWYRR; -.
DR OrthoDB; 1313583at2759; -.
DR PhylomeDB; O70218; -.
DR TreeFam; TF320562; -.
DR BioGRID-ORCS; 15371; 0 hits in 74 CRISPR screens.
DR PRO; PR:O70218; -.
DR Proteomes; UP000000589; Chromosome 5.
DR RNAct; O70218; protein.
DR Bgee; ENSMUSG00000067438; Expressed in superior cervical ganglion and 41 other tissues.
DR ExpressionAtlas; O70218; baseline and differential.
DR Genevisible; O70218; MM.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0003677; F:DNA binding; IMP:UniProtKB.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0001227; F:DNA-binding transcription repressor activity, RNA polymerase II-specific; IMP:NTNU_SB.
DR GO; GO:0000977; F:RNA polymerase II transcription regulatory region sequence-specific DNA binding; IMP:NTNU_SB.
DR GO; GO:0043565; F:sequence-specific DNA binding; ISO:MGI.
DR GO; GO:1990837; F:sequence-specific double-stranded DNA binding; ISO:MGI.
DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IMP:NTNU_SB.
DR GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IMP:UniProtKB.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd00086; homeodomain; 1.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR017970; Homeobox_CS.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR020479; Homeobox_metazoa.
DR Pfam; PF00046; Homeodomain; 1.
DR PRINTS; PR00024; HOMEOBOX.
DR SMART; SM00389; HOX; 1.
DR SUPFAM; SSF46689; SSF46689; 1.
DR PROSITE; PS00027; HOMEOBOX_1; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
PE 2: Evidence at transcript level;
KW Developmental protein; DNA-binding; Homeobox; Nucleus; Reference proteome;
KW Repressor; Transcription; Transcription regulation.
FT CHAIN 1..332
FT /note="Homeobox protein HMX1"
FT /id="PRO_0000278454"
FT DNA_BIND 191..250
FT /note="Homeobox"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT REGION 28..170
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOTIF 251..261
FT /note="HMX family specific domain 1"
FT MOTIF 264..277
FT /note="HMX family specific domain 2"
SQ SEQUENCE 332 AA; 35054 MW; 5D1A9F8439ABF310 CRC64;
MPDELTEPGR ATPARASSFL IENLLAAEAK GAGRSTQGDG VREEEEEDDD DPEDEDPEQA
RRRLQRRRQQ RAGSGPGGEA RARALGLGPR PPPGPGPPFA LGCGGTTRWY PRVHGGYGGG
LSPDTSDRDS PETGEEMGRA ESAWPRCPGP GTVPREVTTQ GPATGGEEAA ELAEAPAVAA
AATGEARGGR RKKTRTVFSR SQVFQLESTF DLKRYLSSAE RAGLAASLQL TETQVKIWFQ
NRRNKWKRQL AAELEAASLS PPGAQRLVRV PVLYHESPPA AAGPALPFPL APPAPAPPPP
LLGFSGALAY PLAAFPAAAS VPFLRAQMPG LV
